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Article

Acute Kidney Injury in Very Low Birth Weight Infants: A Major Morbidity and Mortality Risk Factor

by
Gilad Lazarovits
1,2,†,
Noa Ofek Shlomai
1,2,†,
Raed Kheir
2,
Tali Bdolah Abram
2,
Smadar Eventov Friedman
1,2,*,‡ and
Oded Volovelsky
2,3,‡
1
Department of Neonatology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, Israel
2
School of Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, Israel
3
Pediatric Nephrology Unit, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, Israel
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
‡
These authors also contributed equally to this work.
Children 2023, 10(2), 242; https://doi.org/10.3390/children10020242
Submission received: 28 December 2022 / Revised: 13 January 2023 / Accepted: 26 January 2023 / Published: 29 January 2023
(This article belongs to the Special Issue Advances in Pediatric Acute Kidney Injury)
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Abstract

Background and objectives: Very low birth weight (VLBW) infants are at high risk of developing acute kidney injury (AKI), presumably secondary to low kidney reserves, stressful postnatal events, and drug exposures. Our study aimed to identify the prevalence, risk factors, and outcomes associated with AKI in VLBW infants. Study design: Records of all VLBW infants admitted to two medical campuses between January 2019 and June 2020 were retrospectively reviewed. AKI was classified using the modified KDIGO definition to include only serum creatinine. Risk factors and composite outcomes were compared between infants with and without AKI. We evaluated the main predictors of AKI and death with forward stepwise regression analysis. Results: 152 VLBW infants were enrolled. 21% of them developed AKI. Based on the multivariable analysis, the most significant predictors of AKI were the use of vasopressors, patent ductus arteriosus, and bloodstream infection. AKI had a strong and independent association with neonatal mortality. Conclusions: AKI is common in VLBW infants and is a significant risk factor for mortality. Efforts to prevent AKI are necessary to prevent its harmful effects.
Keywords: acute kidney injury; very low birth weight; patent ductus arteriosus; bloodstream infections; vasopressors; prematurity; preterm birth acute kidney injury; very low birth weight; patent ductus arteriosus; bloodstream infections; vasopressors; prematurity; preterm birth
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MDPI and ACS Style

Lazarovits, G.; Ofek Shlomai, N.; Kheir, R.; Bdolah Abram, T.; Eventov Friedman, S.; Volovelsky, O. Acute Kidney Injury in Very Low Birth Weight Infants: A Major Morbidity and Mortality Risk Factor. Children 2023, 10, 242. https://doi.org/10.3390/children10020242

AMA Style

Lazarovits G, Ofek Shlomai N, Kheir R, Bdolah Abram T, Eventov Friedman S, Volovelsky O. Acute Kidney Injury in Very Low Birth Weight Infants: A Major Morbidity and Mortality Risk Factor. Children. 2023; 10(2):242. https://doi.org/10.3390/children10020242

Chicago/Turabian Style

Lazarovits, Gilad, Noa Ofek Shlomai, Raed Kheir, Tali Bdolah Abram, Smadar Eventov Friedman, and Oded Volovelsky. 2023. "Acute Kidney Injury in Very Low Birth Weight Infants: A Major Morbidity and Mortality Risk Factor" Children 10, no. 2: 242. https://doi.org/10.3390/children10020242

APA Style

Lazarovits, G., Ofek Shlomai, N., Kheir, R., Bdolah Abram, T., Eventov Friedman, S., & Volovelsky, O. (2023). Acute Kidney Injury in Very Low Birth Weight Infants: A Major Morbidity and Mortality Risk Factor. Children, 10(2), 242. https://doi.org/10.3390/children10020242

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