Pediatric COVID-TB: A Clinical Perspective Based on the Analysis of Three Cases
Abstract
:1. Introduction
2. Case Report, Clinical Features of Pediatric COVID-TB Cases
3. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Pt.1 | Pt. 2 | Pt. 3 | |
---|---|---|---|
Age of SARS-CoV-2 infection | 5 y and 1 m | 11 y | 9 y |
Age of TB infection | 4 y and 3 m | 11 y and 3 m | 9 y |
Sex | F | F | F |
Previous TB | Yes | Yes | No |
Site | Lymphadenitis | Lung, mediastinal, and splenic | Lung, Bone (Pott’s Disease) |
Symptoms at admission | Lymph nodes swelling | Dyspnea | Lymph nodes swelling |
Positive Intradermal Mantoux | Yes | Yes | Yes |
IGRA | Yes | Yes | Yes |
Chest CT imaging consistent with TB | Yes | Yes | No |
Chest CT imaging consistent with SARS-CoV-2 infection | No | No | No |
TB Therapy | Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide | Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide | Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide |
Surgery | Excision of right submandibular granulomatous lesion | None | Orthopedic procedure |
SARS-CoV-2 infection therapy * | None | Enoxaparin Azithromycin Dexamethasone | None |
O2 therapy | None | None | None |
Day of negativization | 21 | 14 | 14 |
VOC ** [18] | Omicron BA.1 | Alpha | Omicron BA.1 |
Leucocyte count (5.5–15 103/uL) | 5.17 | 4 | 15.71 |
Neutrophil count (2–8 103/uL) | 3.54 | 2.08 | 12.61 |
Lymphocyte count (2.2–8.55 103/uL) | 1.14 | 1.47 | 2.05 |
CRP (<0.5 mg/dL) | 0.45 | 0.38 | 8 |
Immunoglobulins | |||
IgA | Normal | Normal | Normal |
IgG | Normal | Normal | Normal |
IgM | Normal | Normal | Normal |
Lymphocyte subpopulations | |||
CD3 Pan T | 62.90% | 80.80% | 79.00% |
CD4 T Helper | 34.90% | 42.80% | 39.80% |
CD8 T Suppr/Cytotox | 20.30% | 28.30% | 30.10% |
CD19 Pan B | 27.70% | 10.60% | 16.70% |
CD16+CD56+ | 8.40% | 7.50% | 4.00% |
CD4+/CD8+ | 1.7 | 1.5 | 1.3 |
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Leone, F.; Di Giuseppe, M.; De Luca, M.; Cursi, L.; Calo Carducci, F.I.; Krzysztofiak, A.; Chiurchiù, S.; Romani, L.; Russo, C.; Lancella, L.; et al. Pediatric COVID-TB: A Clinical Perspective Based on the Analysis of Three Cases. Children 2023, 10, 863. https://doi.org/10.3390/children10050863
Leone F, Di Giuseppe M, De Luca M, Cursi L, Calo Carducci FI, Krzysztofiak A, Chiurchiù S, Romani L, Russo C, Lancella L, et al. Pediatric COVID-TB: A Clinical Perspective Based on the Analysis of Three Cases. Children. 2023; 10(5):863. https://doi.org/10.3390/children10050863
Chicago/Turabian StyleLeone, Fabrizio, Martina Di Giuseppe, Maia De Luca, Laura Cursi, Francesca Ippolita Calo Carducci, Andrzej Krzysztofiak, Sara Chiurchiù, Lorenza Romani, Cristina Russo, Laura Lancella, and et al. 2023. "Pediatric COVID-TB: A Clinical Perspective Based on the Analysis of Three Cases" Children 10, no. 5: 863. https://doi.org/10.3390/children10050863