Bayesian Analysis Used to Identify Clinical and Laboratory Variables Capable of Predicting Progression to Severe Dengue among Infected Pediatric Patients
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. General Description of the Cases and Controls
3.2. Comparison between Groups of the Clinical Conditions and Laboratory Parameters
3.3. Identification of the Variables Capable of Prognosis of Severe Dengue
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Clinical Variables | Cases (n = 32) | Controls (n = 67) | Fisher’s Exact Test p-Value |
---|---|---|---|
Mucosal bleeding | 14 | 13 | 0.0157 |
Substantial escape of blood plasma with a weak or undetectable pulse | 8 | 1 | 0.0004 |
Tachycardia | 15 | 1 | <0.0001 *** |
Cold hands and feet | 11 | 1 | <0.0001 *** |
Respiratory failure | 15 | 2 | <0.0001 *** |
Hematemesis | 8 | 3 | 0.0045 |
Alterations in consciousness | 5 | 0 | 0.0028 |
Diaphoresis | 5 | 2 | 0.0342 |
Fainting | 5 | 2 | 0.0342 |
Conjunctivitis | 3 | 0 | 0.0316 |
Cough | 7 | 4 | 0.0352 |
Dyspnea | 8 | 1 | 0.0004 |
Stupor | 4 | 0 | 0.0096 |
Disorientation | 4 | 0 | 0.0096 |
Shock | 5 | 0 | 0.0028 |
Pleural effusion | 7 | 3 | 0.0120 |
Mottled skin | 3 | 0 | 0.0316 |
Comorbidities | 7 | 2 | 0.0047 |
Hemorrhage | 16 | 13 | 0.0040 |
Laboratory Variables | Cases (n = 32) x (SD) | Controls (n = 67) x (SD) | Student’s t-Test p-Value |
---|---|---|---|
Hematocrit | 38.58 (8.77) | 39.76 (6.07) | 0.4377 |
Hb gr/100 mL | 13.34 (3.09) | 13.86 (2.10) | 0.3277 |
Platelet × 103 | 39.63 (58.00) | 62.54 (55.92) | 0.0626 |
Albumin gr/Dl | 2.95 (0.67) | 3.61 (0.50) | <0.0001 *** |
Leukocytes × 103 | 7.77 (4.49) | 5.22 (2.70) | 0.0007 * |
Lymphocytes × 103 | 1.94 (1.36) | 1.72 (1.13) | 0.3989 |
ALT | 215.71 (818.36) | 53.65 (42.93) | 0.1073 |
AST | 757.02 (2841.69) | 138.19 (95.34) | 0.0765 |
DB | 0.26 (0.40) | 0.12 (0.07) | 0.0063 ** |
TB | 0.80 (0.53) | 0.60 (0.24) | 0.0110 * |
Alkaline phosphatase u/L | 133.73 (62.94) | 141.48 (40.86) | 0.4636 |
C-reactive protein mg/Dl | 4.67 (7.57) | 1.11 (1.53) | 0.0003 ** |
Neutrophils × 103 | 4.13 (3.26) | 2.75 (2.00) | 0.0109 * |
Total proteins | 5.22 (1.05) | 6.15 (0.71) | <0.0001 *** |
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Corzo-Gómez, J.; Guzmán-Aquino, S.; Vargas-De-León, C.; Megchún-Hernández, M.; Briones-Aranda, A. Bayesian Analysis Used to Identify Clinical and Laboratory Variables Capable of Predicting Progression to Severe Dengue among Infected Pediatric Patients. Children 2023, 10, 1508. https://doi.org/10.3390/children10091508
Corzo-Gómez J, Guzmán-Aquino S, Vargas-De-León C, Megchún-Hernández M, Briones-Aranda A. Bayesian Analysis Used to Identify Clinical and Laboratory Variables Capable of Predicting Progression to Severe Dengue among Infected Pediatric Patients. Children. 2023; 10(9):1508. https://doi.org/10.3390/children10091508
Chicago/Turabian StyleCorzo-Gómez, Josselin, Susana Guzmán-Aquino, Cruz Vargas-De-León, Mauricio Megchún-Hernández, and Alfredo Briones-Aranda. 2023. "Bayesian Analysis Used to Identify Clinical and Laboratory Variables Capable of Predicting Progression to Severe Dengue among Infected Pediatric Patients" Children 10, no. 9: 1508. https://doi.org/10.3390/children10091508