Synthesis and Characterization of Nanoformulation of the Broad-Spectrum Enzyme Inhibitor Mancozeb by Polyethylene Glycol Capping and Its Dissipation Kinetics in Water Using TiO2 Nanoparticles
Round 1
Reviewer 1 Report
The submitted manuscript is interesting and in the topic of the journal. But some aspects are bellow listed in order to enhance the scientific quality:
- The state of the art should be updated, by considering the pioneering references in the field of nanoparticles and nanocapsules preparation for drug delivery. See for instance the reported works by H. Fessi et al. in International Journal of Pharmaceutics.
- Size size distribution of all prepared nanoparticles should be provided (if possible)
-What is the meaning of Nanoformulation? In my opinion this term has no meaning and should be totally removed from the manuscript.
- Nanopesticid, has no meaning too!
- The optimized condition for decontamination should be put forward and deeply discussed.
- Can TiO2 be recycled ? in order to be use many times?
- As a general remark, the residual as a function of catalyst amount should be more discussed rather than presenting results only.
- Conclusion should be more highlighted
Author Response
Please see the attachment
Author Response File: 
Author Response.pdf
Reviewer 2 Report
1. You may remove the numbers in the Y axis of the XRD figure and adjust the axis range
2. Nanoparticles seems to agglomerated. What could be the reason
3. Whole process have taken more than 30 hours. Explain
4. Fugure 11. If can please plot them by your own rather including the images obtained.
Overall the study is interesting. Please improve the manuscript interms of above facts.
Author Response
Please see the attachment
Author Response File: Author Response.pdf
Reviewer 3 Report
Comments and Suggestions for Authors
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Comments and Suggestions |
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1-2 |
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Abstract; The Poly(Ethylene) Glycol (PEG) capped mancozeb nano formulation was prepared by the microwave irradiation method using a 1% mancozeb solution and 20% capping agent, PEG-4000 |
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90-98 |
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However, in the Experiments Section : There is no microwave been used |
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81-87
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Reagents and Chemicals : There is no RO water included |
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99-105 |
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3.1. Preparation of TiO2 nanoparticles: A precipitate of TiO2 nanoparticles was obtained by decanting methanol into a glass Something un-cleared with "decanting methanol", because there is no methanol was used |
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116-122 |
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3.5. Preparation of mancozeb Standard Stock Solution: Please rewrite with more simple and cleared |
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145-147 |
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Transferred the supernent in to the amber colored bottles and stored in dark at < 5â—¦C until analysis to avoid further degradation of residues. What does supernent means ?? |
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157-158 |
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3.9. Chromatographic separation parameters Herbicide residues were separated using the Zorbex Eclipse C18 (250 × 4.6 mm, 5 m) Could you please check again the name and spec of the column used |
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171 |
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4. Results and Discussion 4.1. Characterization of TiO2 NPs and Mancozeb Nano formulation In my opinion you don’t have to put “the Mancozeb Nano formulation” because there is no explanation about it |
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199-200 |
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4.1.3. SEM Analysis of TiO2 NPs and Mancozeb Nano formulation SEM micrograph revealed the presence of particles with irregular shapes and sizes (Figure 5). Please described, what particles they are ? |
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247
245-280 |
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5. Conclusions Polycaprolactone was used as a capping ingredient in the formulation of mancozeb nanoformulation.I couln’t find Polycaprolactone involved in this experiment Please, make the conclusion focus on what the results obtained |
Comments for author File: Comments.pdf
Author Response
Please see the attachment.
Author Response File: Author Response.pdf
