Infection Control Measures against Candidaauris in Healthcare Facilities
Round 1
Reviewer 1 Report
Thank you for writing the review article. In my opinion, the review of the topic can be enhanced. The authors may want to consider compiling a table summarizing the incidences of C. auris in the healthcare setting for a more comprehensive coverage.
Please provide references in Table 1.
Include mentioning of position statements relevant to the contents of the article.
Discuss and provide recommendations.
Author Response
Please see the attachment
Author Response File: 
Author Response.docx
Reviewer 2 Report
Dear Authors,
You did a good job in a subject of real importance in current times.
I suggest to complete table 2 with some of the information related with the decontamination of environmental surfaces that appeared in the text of the paper.
I highlighted some words that must be italics, or in plural, etc.
Comments for author File: 
Comments.pdf
Author Response
Please see the attachment.
Author Response File: Author Response.docx
Reviewer 3 Report
The review entitled Infection control measures against Candida auris in healthcare facilities by Alfouzan et al., showed what are control measure for C. auris preventions. The review is well structured however below are some examples of issues in which the authors might want to work on.
1. In the abstract the authors have not summarized the control measures/ and different methods used to detect c. auris infection. The authors should address this problem and must update the abstract and restructure the abstract so that it should be clear to readers.
2. In introduction also I can not find any paragraph mentioning the control measures of the c. auris since from the title of the review the main emphasis of the review is control measures against Candida auris. The introduction should be updated and latest references should be added since lot of literature is available.
3. Line 52 the subheading c. auris, there should be more details mentioning the biology of c. auris for the references below is the article which might help authors to add more about biology of c, auris.
https://www.sciencedirect.com/science/article/pii/S0944501320304894
4. There should be a section for the associated risk factors of auris.
5. In the section Transmission of C. auris it would be better if authors will add the flow chart or graphical figure for the Transmission of C. auris.
6. In the table 1 authors should mention the source/ references for the Different disinfectants and antiseptic agents used against C. auris.
7. The manuscript should be updated what are the major diagnostic challenges for the detection of c. auris.
8. The conclusion should be restructured as it is not addressing the theme of the manuscript.
Manuscript should be revised.
Author Response
Editor in Chief July 19, 2022
Processes
Subject: response to reviewer #3 comments : manuscript ID: processes-1804360 - Infection control measures against Candida auris in healthcare facilities
Thank you very much for sending us the comments of the Reviewer on the above manuscript. We have modified the manuscript in the light of comments and suggestions of the Reviewers. A point-by-point response to the various comments/suggestions of the Reviewers are as follows:
Reviewer #3:
- Comment: The review entitled Infection control measures against Candida auris in healthcare facilities by Alfouzan et al., showed what are control measure for C. auris preventions. The review is well structured however below are some examples of issues in which the authors might want to work on.
Reply: We appreciate the positive comments of the reviewer.
- Comments: In the abstract the authors have not summarized the control measures/ and different methods used to detect c. auris infection. The authors should address this problem and must update the abstract and restructure the abstract so that it should be clear to readers.
Reply: The Abstract has been modified:
- Comment: In introduction also I can not find any paragraph mentioning the control measures of the c. auris since from the title of the review the main emphasis of the review is control measures against Candida auris. The introduction should be updated and latest references should be added since lot of literature is available.
Reply: introduction has been modified as requested.
- Comment: Line 52 the subheading c. auris, there should be more details mentioning the biology of c. auris for the references below is the article which might help authors to add more about biology of c, auris.
https://www.sciencedirect.com/science/article/pii/S0944501320304894
Reply: A section on Biology of C. auris is added as recommended by reviewer.
- Comment: There should be a section for the associated risk factors of auris.
Reply: Risk factor section added as recommended by reviewer.
- Comment: In the section Transmission of C. auris it would be better if authors will add the flow chart or graphical figure for the Transmission of C. auris.
Reply: Transmission of C. auris is like any other pathogen which has propensity to spread. I am not sure how to produce the figure suggested.
- Comment: In the table 1 authors should mention the source/ references for the Different disinfectants and antiseptic agents used against C. auris.
Reply: table 1 is updated as suggested.
- Comment: The manuscript should be updated what are the major diagnostic challenges for the detection of c. auris.
Reply: Section has been modified line 97.
- Comment: The conclusion should be restructured as it is not addressing the theme of the manuscript.
Manuscript should be revised.
Reply: Summary has been modified
Awaiting your positive feedback
Kind regards,
Dr. Wadha Alfouzan
MB:BS, MSc, FRCPath
Assistant Professor of Clinical Microbiology
Department of Microbiology
Faculty of Medicine, Kuwait University
- O. Box 24923, Safat 13110
Kuwait (+965-2498-6516)
Author Response File: Author Response.docx
Reviewer 4 Report
The authors aimed to provide an update on best practices for control of Candida auris transmission in healthcare facilities, based on available information, recently published by the Infection Prevention and Control working group of the International Society for Antimicrobial Chemotherapy.
The study covers some issues that have been overlooked in other similar topics. The structure of the manuscript appears adequate and well divided in the sections. Moreover, the study is easy to follow, but some issues should be improved. Some of the comments that would improve the overall quality of the study are:
a. Authors must pay attention to the technical terms acronyms they used in the text.
b. English language needs to be revised.
c. Conclusion Section: This paragraph required a general revision to eliminate redundant sentences and to add some "take-home message".
Author Response
Please see the attachment
Author Response File: Author Response.docx
Round 2
Reviewer 1 Report
Thank you for taking the comments into consideration in the revision of the manuscript. Please italicize C. auris throughout the article.
Author Response
Editor in Chief August 10, 2022
Processes
Subject: response to reviewer #1 second round comments: manuscript ID: processes-1804360 - Infection control measures against Candida auris in healthcare facilities
Thank you very much for sending us the comments of the Reviewer on the above manuscript. We have reviewed the manuscript in the light of comments and suggestions of the Reviewer in round two. A point-by-point response to the various comments/suggestions of the Reviewers are as follows:
Reviewer #2:
- Comment: Thank you for taking the comments into consideration in the revision of the manuscript.
Response: most welcome, we thank you for your revision and positive response.
- Comment: Please italicize C. auris throughout the article.
Response: all C. aruis has been revised and italicized throughout the manuscript.
Kind regards,
Dr. Wadha Alfouzan
MB:BS, MSc, FRCPath
Assistant Professor of Clinical Microbiology
Department of Microbiology
Faculty of Medicine, Kuwait University
- O. Box 24923, Safat 13110
Kuwait (+965-2498-6516)
Reviewer 3 Report
thank you for providing the revised version of the manuscript. the manuscript has been improved however there is no section describing the biology of the C. auris please add the section. Second C.auris should be italic in the manuscript.
Author Response
Editor in Chief August 10, 2022
Processes
Subject: response to reviewer #3 second round comments: manuscript ID: processes-1804360 - Infection control measures against Candida auris in healthcare facilities
Thank you very much for sending us the comments of the Reviewer on the above manuscript. We have reviewed the manuscript in the light of comments and suggestions of the Reviewer in round two. A point-by-point response to the various comments/suggestions of the Reviewers are as follows:
Reviewer #2:
- Comment: thank you for providing the revised version of the manuscript. the manuscript has been improved however there is no section describing the biology of the auris please add the section.
Response: most welcome, we thank you for your revision and positive response.
- Comment: There is no section describing the biology of the auris please add the section.
Response: a small section added under C. auris about biology.
Biofilm formation has been described as one of the important pathogenicity traits in C. auris. This characteristic can lead the fungus to become resistant to antifungal agents and is also likely to play a role in its ability to persist on various surfaces. The other virulence attributes in C. auris are due to phospholipases and proteinase production, nutrient acquisition, siderophore-based iron acquisition, two-component histidine kinase system and cell wall modeling. C. auris has also demonstrated ability to evade immune response, especially killing by neutrophils (GustavoBravo Ruiz, 2021).
- Comment: Second auris should be italic in the manuscript.
Response: all C. aruis has been revised and italicized throughout the manuscript.
Kind regards,
Dr. Wadha Alfouzan
MB:BS, MSc, FRCPath
Assistant Professor of Clinical Microbiology
Department of Microbiology
Faculty of Medicine, Kuwait University
- O. Box 24923, Safat 13110
Kuwait (+965-2498-6516)
