Simulating Tablet Dissolution Using Computational Fluid Dynamics and Experimental Modeling

Round 1

Reviewer 1 Report

This is an interesting study that compares CFD simulation of tablet dissolution to experimental results and should contribute to understanding mechanisms. 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

As the attached PDF file.

Comments for author File: Comments.pdf

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 3 Report

Many thanks to the authors for submitting the manuscript for review and I congratulate them on thorough piece of work. The main point I would like to see clarified and  further expanded is the the link between pharmaceutical dissolution (upon which this modelling is based) and food, particularly as the CFD is based on a compacted benzoic acid tablet as per Langrish et al.

Secondly I would like to see a discussion as to why there has been such a gap in the research between the cited works of D'arcy et al and the work of Langrish (2021) and the current experimental design (~15 years). Does this suggest a  lack of relevance/ importance of the research.

In addition I would like to see each case where data has been taken directly from previous publications to be highlighted more clearly. For example in in Table 2 it is clearly stated that the data experimental data are taken from Langrish et al.  but for Figure 10 it is not stated the origin of the experimental data.

While it may be beyond the scope of this work the role of tablet hardness should be considered and its importance should be brought to the readers attention during discussion of the results if only a single tablet hardness was used throughout all experimentation.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Round 2

Reviewer 3 Report

The authors have addressed my comments and concerns and I am happy for the paper to be accepted in its current form

Author Response

Thanks, and the reviewer has accepted our revised paper. No response is required.

 

 

Author Response File: Author Response.docx