The Effects of Conjugated Linoleic Acids on Cancer
Abstract
:1. Introduction
2. Animal Models
2.1. Colon Cancer
2.2. Breast and Mammary Cancer
2.3. Prostate Cancer
2.4. Pancreatic and Liver Cancer
3. Cellular Models
3.1. Colon Cancer
3.2. Breast and Mammary Cancer
3.3. Prostate Cancer
3.4. Liver Cancer
3.5. Skin Cancer
4. Clinical Studies
4.1. Colon Cancer
4.2. Breast Cancer
5. Cellular Mechanisms by Which CLA May Inhibit Cancer
5.1. Anti-Cancer Initiation
5.2. Anti-Cancer Promotion
5.3. Anti-Proliferative
6. Discussion
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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CancerType | Inducer | Animal | CLA Source | Effects | Reference |
---|---|---|---|---|---|
Colon | DMD 1 | SD rats | CLA mixture | Incresed apoptotic index, lower number of tumors. | Park et al. [23] |
Colon | AOM 2 | SD rats | CLA mixture | Incresed apoptosis, and activity of Caspase-3. | Shiraishi et al. [24] |
Colon | Crypt fission | Apc(min/+) mice | c9, t11-CLA t10, c12-CLA | Decrease polyp size. Increase polyp size. | Mandir et al. [25] |
Colon | Unhealthy diet | Apc(min/+) mice | CLA mixture | No effect. | Petrik et al. [26] |
Colon and pulmonary | NMU 3 | BALB/c mice | c9, t11-CLA t10, c12-CLA | Inhibit cancer cell migration, reduced pulmonary nodules. | Soel et al. [27] |
Colon | AOM | SD rats | c9, t11-CLA | Inhibit aberrant crypts, enhanced killer cell activiy. | Nichenametla et al. [28] |
Colon | DMH 4 | SD rats | CLA mixture | Reduced tumor incidence, increase apoptosis. | Kim et al. [29] |
Colon | AOM | BALB/c mice | CLA mixture | Decreased metastatic foci, activation PPRn. | Sasaki et al. [30] |
Mammary | DMBA 5 | SD rats | CLA mixture | No effect. | Ip et al. [31] |
Mammary and breast | DMBA | SD rats | CLA mixture | Inhibit PUFA oxidation. | Bialek et al. [32] |
Breast | DMBA | SCID rats | CLA mixture | Reduced tumor growth. | Visonneau et al. [33] |
Mammary | DMBA | BALB/c mice | CLA mixture | Prolong tumor latency, decresed tumor burden. | Hubbard et al. [34] |
Breast | DMBA | BALB/c mice | c9, t11-CLA | Reduced tumor growth in conjugate with gemcitabine. | Tao et al. [35] |
Mammary | MNU 6 | SD rats | c9, t11-CLA | Decressed tumor mass per animal. | Lavillonneiere et al. [36] |
Mammry and breast | DMBA | SD rats | c9, t11-CLA | Decreased tumor weight and volume. | Zeng et al. [37] |
Breast | MNU | SD rats | CLA mixture | Decresed terminal and bud cell density. | Ip et al. [38] |
Prostate | DMBA | SCID mice | CLA mixture | Inhibit cancer cell grovth. | Cesano et al. [39] |
Prostate | PhIP 7 | Big blue rats | CLA mixture | Inhibit the formation of PhIP→DNA. | Yang et al. [40] |
Prostate | AIN-76A diet | Copenhagen rats | CLA mixture | Apoptotic activity and citotoxycity. | Jung et al. [41] |
Prostate | PhIP | Copenhagen rats | CLA mixture | Not beneficiary alone, effect with isoflavone. | Cohen et al. [42] |
Pancreas | BOP 8 | Syrian hamster | CLA mixture | No effect. | Kilian et al. [43,44] |
Liver | AOM | Male F344 rats | c9, t11-CLA | Tumor inhibition, increse expression of PPRn. | Kohno et al. [45] |
Liver | AOM | Donryu rats | CLA mixture | Induce hepatic lipid peroxidation and accumulation. | Yamasaki et al. [46] |
CancerType | Cell Lines | CLA Source | Effects | Reference |
---|---|---|---|---|
Colon | HT-29 | CLA mixture | Inhibition proliferation by ErbB3 signaling. | Cho et al. [47] |
Colon | HT-29 | c9, t11-CLA, t10, c12-CLA | Inhibition proliferation by ErbB3 signaling. | Cho et al. [48] |
Prostate and colon | HT-29, PC-3, MIP-101 | c9, t11-CLA, t10, c12-CLA | Inhibition effect, caspase dependent. | Palombo et al. [49] |
Colon | Caco-2 | t10, c12-CLA c9, t11-CLA | t10, c12-CLA inhibition proliferation. Decresed insulin-like growth factor II (IGF-II) expression. c9, t11-CLA no effect. | Kim et al. [50] |
Colon | Caco-2 | c9, t11-CLA | Antiproliferative effect, repressed expresiion c-myc, cyclin D1 in a PPARn | Lampen et al. [51] |
Colon | HT-29 | CLA mixture | Induced cell cycle arrest at G0/G1 phase | Lim et al. [52] |
Gastric | SGS-7901 | c9, t11-CLA | Reduced adhesion. Increased the level of ECD and α-catenin. Decrease ICAM-1 and VCAM-1 | Chen et al. [53] |
Breast | MCF-7, MDA-MB-231- ERα | CLA mixture | Induced cell apoptosis by caspase activity. | Wang et al. [54], Sorenmo et al. [55] |
Breast | MCF-7 | c9, t11-CLA t10, c12-CLA | c9, t11-CLA more effective suppress growth. t10, c12-CLA less effective. | O’Shea et al. [56] |
Breast | MCF-7 | c9, t11-CLA, t9, t11-CLA t10, c12-CLA | t9, t11-CLA induced apoptosis, incresed mMRA levels of LXR genes. c9, t11-CLA and t10, c12-CLA less potent. | El Roz et al. [57] |
Breast | MDA-MB-231 | CLA mixture | ERK reduction and upregulation of pro-apoptotic protein Bak | Miglietta et al. [58] |
Breast | MCF-7, MDA-MB-231 | CLA mixture | Inhibition cell cycle, c-myc expression. | Durgam et al. [59] |
Breast | MCF-7 | CLA mixture LA | Inhibition on growth. Stimulation of growth. | Park et al. [60] |
Breast | MCF-10A | t9, t11-CLA, t10, t12-CLA c9, t11-CLA | The anti-promotional activity of t9, t11 and t10, t12-CLA were less potent than c9, t11-CLA. | Rakib et al. [61,62] |
Prostate | DU145 | t10, c12-CLA c9, t11-CLA | t10, c12-CLA inhibited the G1-S cell cycle progression. c9, t11-CLA no effect. | Kim et al. [63] |
Prostate | PC-3 | t10, c12-CLA c9, t11-CLA | t10, c12-CLA apoptosis and cell cycle control. c9, t11-CLA-Regulation of genes for arachidonic acid metabolism. | Ochoa et al. [64] |
Liver | dRLh-84 | c9, t11-CLA, t10, c12-CLA | Different cytotoxic effects. | Yamasaki et al. [65,66] |
Liver | SK-HEP-1 | CLA mixture | Increased PPARα and proapoptotic proteins. Activating apoptotic pathways. | Muzio et al. [67] |
Liver | HepG2 | c9, t11-CLA, t10, c12-CLA | Inhibited cell proliferation and induced apoptotic cell death under hypoxia. | Yamasaki et al. [68] |
Skin | HEL-30 | Radioactive (1-14C) CLA | Partial inhibition of tumor promotion. | Liu et al. [69] |
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Dachev, M.; Bryndová, J.; Jakubek, M.; Moučka, Z.; Urban, M. The Effects of Conjugated Linoleic Acids on Cancer. Processes 2021, 9, 454. https://doi.org/10.3390/pr9030454
Dachev M, Bryndová J, Jakubek M, Moučka Z, Urban M. The Effects of Conjugated Linoleic Acids on Cancer. Processes. 2021; 9(3):454. https://doi.org/10.3390/pr9030454
Chicago/Turabian StyleDachev, Marko, Jana Bryndová, Milan Jakubek, Zdeněk Moučka, and Marian Urban. 2021. "The Effects of Conjugated Linoleic Acids on Cancer" Processes 9, no. 3: 454. https://doi.org/10.3390/pr9030454