Panniculitis in Children

Round 1

Reviewer 1 Report

Table 1. Title is not correct. Why panniculitis during vemurafenib is underlined?

What do you mean by Cytotoxic T cell panniculitis? Even when I have read the text, looks like an activation of T cells due to TIM3. May be a more concise name possible?

Regarding SFN it is noteworthy than in sclerema neonatorum as the newborn is severely affected, scarce or absent inflammatory infiltrate is observed. This idea should be added to the text.

As first panniculitis is SFN, it should be 1. SFN. 

Regarding 4. Autoinflammatory diseases, why polyarteritis-nodosa is writeen in bigger lettering? In the introducction they can additionally have granulomatous or vasculitis. The phrase is not clear enough algthouth the examples are good.

4-1-2. Nakajo -Nishimura is not another name to the same entity? Please, clarify! Please use same lettering

There is no vasculitis per se. Per se can be deleted. No added infomration.

4-1-4 Plesae, define better otulipenia. If vasculitis is present, add the entity in the right place in the table. 

6-panniculitis in self healing cutaneous mucinosis. I am not so sure this can be named panniculitis. Please, clarify. 

Author Response

Table 1. Title is not correct. Why panniculitis during vemurafenib is underlined?

Thanks I corrected

What do you mean by Cytotoxic T cell panniculitis? Even when I have read the text, looks like an activation of T cells due to TIM3. May be a more concise name possible? 

It is a descriptive term, we used it as it was already used in some publications . It is used also in some lymphoproliferative disorders . I changed the text and suggested this name.

Regarding SFN it is noteworthy than in sclerema neonatorum as the newborn is severely affected, scarce or absent inflammatory infiltrate is observed. This idea should be added to the text.

Thanks I added this idea

As first panniculitis is SFN, it should be 1. SFN. Thanks I corrected

Regarding 4. Autoinflammatory diseases, why polyarteritis-nodosa is writeen in bigger lettering? In the introducction they can additionally have granulomatous or vasculitis. The phrase is not clear enough algthouth the examples are good.  

Thanks I corrected.

4-1-2. Nakajo -Nishimura is not another name to the same entity? Please, clarify! Please use same lettering  

Thanks for this comment  I corrected , Nakajo Nishimura syndrome (NNS)CANDLE and JMP are a group of disease sharing a common molecular cause with similar clinical features .NNS was described in Japan

There is no vasculitis per se. Per se can be deleted. No added infomration.

Thanks I corrected

4-1-4 Plesae, define better otulipenia. If vasculitis is present, add the entity in the right place in the table.

I added some information and as  vasculitis is  sometimes reported, I did include  otulopenia in the Table

6-panniculitis in self healing cutaneous mucinosis. I am not so sure this can be named panniculitis. Please, clarify. 

We really think that this diagnosis must be evoked  as the histologic aspect of sel-healing mucinosis is  non-specific with a chronic lobular panniculitis or shows a proliferative fasciitis . Of course we will withdraw it if you prefer.

Reviewer 2 Report

The authors Moulonguet and Fraitag present an excellent review article about the difficult topic of panniculitides with pediatric panniculitides as rarities being the main focus of the manuscript. Although some histopathological descriptions are quite short, this article will be of great interest for a dermatohistopathological audience. It includes great clinical and histopathological photographs.

However, I would suggest some minor modifications to further improve the manuscript as follows:

Major remarks:

• None

Minor remarks:

- Table 1: The title is not correct. Please indicate why some lines are dotted or exclude the dotted line. Please include table description and point out abbreviations.

- Please check Figure 8 and Figure 9 as they do not correspond to the text and to the figure legends. Figure 8 should be aluminum granuloma and figure 9 lupus panniculitis (which must also be referred to in the text).  

- Style remarks:

Page 2 line 47: Should be numbered 1, not I

Figure legends should be uniform in the description of subpanels, e.g. A. xxxx B.  and so on. ; Figure legends should give an information about the magnification of the histopathological illustrations.

Please pay attention to missing or superfluous spaces throughout the manuscript, e.g. Page 2 line 53

Please pay attention to consistent use of present or past tense, e.g. Page 4 line 81 (manifests); page 5 line 123 (has been); page 17 line 450 (include)

Please pay attention to consistent size and style of the font, e.g. page 5 line 126; e.g. page 7 line 162-163; e.g. page 8 line 190; page 8 line 200

superfluous words, e.g. page 7 line 143 (with BS) ; page 9 line 231

wrong or superfluous underlining, e.g page 8 line 209; page 13 line 320; page 13 line 325-326

Misspelled, e.g. Page 10 line 270 (Christina Mitteldorf); page 15 line 369 (exsudation); page 17 line 449 (sometimes)

Please delete because it is mentioned twice: Page 16 line 389

Author Response

The authors Moulonguet and Fraitag present an excellent review article about the difficult topic of panniculitides with pediatric panniculitides as rarities being the main focus of the manuscript. Although some histopathological descriptions are quite short, this article will be of great interest for a dermatohistopathological audience. It includes great clinical and histopathological photographs. Thanks for these very nice comments

However, I would suggest some minor modifications to further improve the manuscript as follows:

Major remarks:

• None

Minor remarks:

- Table 1: The title is not correct. Please indicate why some lines are dotted or exclude the dotted line. Please include table description and point out abbreviations. Thanks I corrected

- Please check Figure 8 and Figure 9 as they do not correspond to the text and to the figure legends. Figure 8 should be aluminum granuloma and figure 9 lupus panniculitis (which must also be referred to in the text). Sorry I corrected

- Style remarks:

Page 2 line 47: Should be numbered 1, not I Thanks I corrected

Figure legends should be uniform in the description of subpanels, e.g. A. xxxx B.  and so on. ; Figure legends should give an information about the magnification of the histopathological illustrations. Thanks I corrected

Please pay attention to missing or superfluous spaces throughout the manuscript, e.g. Page 2 line 53 Thanks I corrected

Please pay attention to consistent use of present or past tense, e.g. Page 4 line 81 (manifests); page 5 line 123 (has been); page 17 line 450 (include) Thanks I corrected

Please pay attention to consistent size and style of the font, e.g. page 5 line 126; e.g. page 7 line 162-163; e.g. page 8 line 190; page 8 line 200 Thanks I corrected

superfluous words, e.g. page 7 line 143 (with BS) ; page 9 line 231 Thanks I corrected

wrong or superfluous underlining, e.g page 8 line 209; page 13 line 320; page 13 line 325-326 Thanks I corrected

Misspelled, e.g. Page 10 line 270 (Christina Mitteldorf); page 15 line 369 (exsudation); page 17 line 449 (sometimes) Thanks I corrected

Please delete because it is mentioned twice: Page 16 line 389 Thanks I corrected

Author Response File: Author Response.docx

Reviewer 3 Report

The paper is a well structured review on the panniculitis in pediatric population.

The manuscript is well written and It can be accepted for publication in its current form.

Congratulation to the authors

Author Response

R 3 Thanks for these nice comments