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Inorganics
Volume 10
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10.3390/inorganics10020023
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Review

Coumarins Synthesis and Transformation via C–H Bond Activation—A Review

by
Katarzyna Szwaczko
Department of Organic Chemistry, Faculty of Chemistry, Institute of Chemical Sciences, Marie Curie-Sklodowska University in Lublin, Gliniana St. 33, 20-614 Lublin, Poland
Inorganics 2022, 10(2), 23; https://doi.org/10.3390/inorganics10020023
Submission received: 18 January 2022 / Revised: 4 February 2022 / Accepted: 11 February 2022 / Published: 15 February 2022
(This article belongs to the Special Issue Bond Activation and Catalysis Using Main-Group Elements)
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Abstract

For several decades, coumarins have attracted considerable attention due to the fact of their application in diverse fields such as medical science and biomedical research as well as several industrial branches. Recently, many compounds containing the coumarin moiety have been intensively studied, mainly due to the fact of their biological activities such as antitumor, antioxidative, anti-HIV, vasorelaxant, antimicrobial, and anticancer. They are also widely used as fluorescent dyes and probes because of their great structural flexibility and large fluorescent quantum yields. For this reason, numerous attempts have been made to develop new and more practical methods for the synthesis of these compounds. This review aims at providing a comprehensive overview of coumarin synthesis methods by direct C–H bond activation in order to demonstrate the current state-of-the-art methods as well as the current limitations.
Keywords: coumarin; C–H bond activation; metal catalysis; C–H functionalization coumarin; C–H bond activation; metal catalysis; C–H functionalization

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MDPI and ACS Style

Szwaczko, K. Coumarins Synthesis and Transformation via C–H Bond Activation—A Review. Inorganics 2022, 10, 23. https://doi.org/10.3390/inorganics10020023

AMA Style

Szwaczko K. Coumarins Synthesis and Transformation via C–H Bond Activation—A Review. Inorganics. 2022; 10(2):23. https://doi.org/10.3390/inorganics10020023

Chicago/Turabian Style

Szwaczko, Katarzyna. 2022. "Coumarins Synthesis and Transformation via C–H Bond Activation—A Review" Inorganics 10, no. 2: 23. https://doi.org/10.3390/inorganics10020023

APA Style

Szwaczko, K. (2022). Coumarins Synthesis and Transformation via C–H Bond Activation—A Review. Inorganics, 10(2), 23. https://doi.org/10.3390/inorganics10020023

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