Metal-Free Reduction of Phosphine Oxides Using Polymethylhydrosiloxane
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
4.1. Methods and Substrates
4.1.1. Synthesis of 3
4.1.2. Synthesis of 8
4.2. Reduction Protocol
Detailed Procedure for the Reduction of 1
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Entry | Substrate | PMHS (equiv.) | T (°C) | t (h) | Yield (%) 2 |
---|---|---|---|---|---|
1 | 1 | 5 | 250 | 0.5 | 24 |
2 | 1 | 5 | 250 | 1 | 45 |
3 | 1 | 5 | 250 | 1.5 | 86 (84) |
4 | 1 | 15 | 250 | 1 | 90 |
5 | 1 | 5 | 200 | 24 | 90 |
6 | 1 | 5 | 220 | 24 | 100 |
7 | 2 | 5 | 220 | 1 | 100 |
8 | 3 | 5 | 250 | 6 | 0 |
9 | 3 | 10 | 200 | 3 | 7 |
10 | 3 | 10 | 200 | 6 | <1 * |
11 | 3 | 15 | 200 | 6 | 10 |
12 | 3 | 15 | 250 | 2 | 20 |
13 | 3 | 15 | 250 | 6 | 5 |
14 | 3 | 15 | 250 | 7 | <1 * |
15 | 4 | 10 | 200 | 3 | 4 |
16 | 4 | 10 | 200 | 6 | 33 |
17 | 4 | 10 | 250 | 3 | 12 |
18 | 4 | 10 | 250 | 6 | 53 |
19 | 4 | 15 | 200 | 3 | 30 |
20 | 4 | 15 | 200 | 7 | 87 |
21 | 4 | 15 | 250 | 3 | 13 |
22 | 4 | 15 | 250 | 7 | 82 |
23 | 5 | 5 | 250 | 1 | 100 |
24 | 6 | 5 | 250 | 1 | 100 |
25 | 6 | 5 | 220 | 1 | 100 |
26 | 7 | 5 | 220 | 1 | 83 (78) |
27 | 8 | 10 | 250 | 1 | <1 * |
28 | 8 | 15 | 200 | 6 | <1 |
29 | 8 | 15 | 200 | 20 | <1 * |
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Nicolas, E.; Guerriero, A.; Lyaskovskyy, V.; Peruzzini, M.; Lammertsma, K.; Gonsalvi, L.; Slootweg, J.C. Metal-Free Reduction of Phosphine Oxides Using Polymethylhydrosiloxane. Inorganics 2016, 4, 34. https://doi.org/10.3390/inorganics4040034
Nicolas E, Guerriero A, Lyaskovskyy V, Peruzzini M, Lammertsma K, Gonsalvi L, Slootweg JC. Metal-Free Reduction of Phosphine Oxides Using Polymethylhydrosiloxane. Inorganics. 2016; 4(4):34. https://doi.org/10.3390/inorganics4040034
Chicago/Turabian StyleNicolas, Emmanuel, Antonella Guerriero, Volodymyr Lyaskovskyy, Maurizio Peruzzini, Koop Lammertsma, Luca Gonsalvi, and J. Chris Slootweg. 2016. "Metal-Free Reduction of Phosphine Oxides Using Polymethylhydrosiloxane" Inorganics 4, no. 4: 34. https://doi.org/10.3390/inorganics4040034