Clinical Efficacy and Safety of Lidocaine Tape for Topical Anesthesia of the Oral Mucosa: A Preliminary Controlled Trial

Tani, Ryouji; Yamasaki, Sachiko; Hamada, Atsuko; Higaki, Mirai; Asada, Yasuyuki; Yanamoto, Souichi

doi:10.3390/dj11120276

Open AccessArticle

Clinical Efficacy and Safety of Lidocaine Tape for Topical Anesthesia of the Oral Mucosa: A Preliminary Controlled Trial

by

Ryouji Tani

^*

,

Sachiko Yamasaki

,

Atsuko Hamada

,

Mirai Higaki

,

Yasuyuki Asada

and

Souichi Yanamoto

Department of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan

^*

Author to whom correspondence should be addressed.

Dent. J. 2023, 11(12), 276; https://doi.org/10.3390/dj11120276

Submission received: 25 October 2023 / Revised: 21 November 2023 / Accepted: 28 November 2023 / Published: 29 November 2023

(This article belongs to the Section Oral and Maxillofacial Surgery)

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Abstract

Local anesthesia is administered to reduce pain-induced stress during dental treatment. However, local anesthetic injections are extremely painful; thus, methods to minimize this pain should be developed. Clinical studies on the pain-relieving effects of dental topical anesthetics have shown that few topical anesthetics provide fast and adequate pain relief without harming the oral mucosa. We examined the efficacy and safety of lidocaine tape, which has a potent topical anesthetic effect. Lidocaine tape was applied to the oral mucosa of 14 healthy participants, and its suppression effect was assessed by examining the pain intensity at the non-lidocaine tape-applied site using the visual analog evaluation scale and the verbal evaluation scale. Lidocaine tape application significantly reduced visual analog scale (VAS) scores during mucosal puncture compared to non-application (p < 0.01). Moreover, lidocaine tape application significantly reduced VAS scores during local anesthetic injection compared to non-application (p < 0.001). Adverse events were evaluated using the Common Terminology Criteria for Adverse Events, version 5.0. No adverse events attributed to the application of lidocaine tape were observed in any participant. The findings in this study suggest that the application of lidocaine tape before infiltration anesthesia can reduce patient distress.

Keywords: administration; topical; infiltration anesthesia; mouth mucosa

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MDPI and ACS Style

Tani, R.; Yamasaki, S.; Hamada, A.; Higaki, M.; Asada, Y.; Yanamoto, S. Clinical Efficacy and Safety of Lidocaine Tape for Topical Anesthesia of the Oral Mucosa: A Preliminary Controlled Trial. Dent. J. 2023, 11, 276. https://doi.org/10.3390/dj11120276

AMA Style

Tani R, Yamasaki S, Hamada A, Higaki M, Asada Y, Yanamoto S. Clinical Efficacy and Safety of Lidocaine Tape for Topical Anesthesia of the Oral Mucosa: A Preliminary Controlled Trial. Dentistry Journal. 2023; 11(12):276. https://doi.org/10.3390/dj11120276

Chicago/Turabian Style

Tani, Ryouji, Sachiko Yamasaki, Atsuko Hamada, Mirai Higaki, Yasuyuki Asada, and Souichi Yanamoto. 2023. "Clinical Efficacy and Safety of Lidocaine Tape for Topical Anesthesia of the Oral Mucosa: A Preliminary Controlled Trial" Dentistry Journal 11, no. 12: 276. https://doi.org/10.3390/dj11120276

APA Style

Tani, R., Yamasaki, S., Hamada, A., Higaki, M., Asada, Y., & Yanamoto, S. (2023). Clinical Efficacy and Safety of Lidocaine Tape for Topical Anesthesia of the Oral Mucosa: A Preliminary Controlled Trial. Dentistry Journal, 11(12), 276. https://doi.org/10.3390/dj11120276

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Clinical Efficacy and Safety of Lidocaine Tape for Topical Anesthesia of the Oral Mucosa: A Preliminary Controlled Trial

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