Osseous Healing in Surgically Prepared Bone Defects Using Different Grafting Materials: An Experimental Study in Pigs
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Surgical Procedure and Experimental Design
2.3. Sacrifice of Animals
2.4. Histologic Analysis
2.5. Histomorphometric Analysis
2.6. Statistical Analysis
3. Results
3.1. Overall
3.2. Histology
3.3. Histomorphometry
4. Discussion
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Graft | Characteristics | Granule Size (mm) |
---|---|---|
Bio-Oss | Bovine, deproteinized bone mineral | 1–2 |
Calc-i-oss | Synthetic, phase-pure beta-tricalcium phosphate | 1–1.6 |
Demokritos | Human, freeze-dried, mineralized, and lyophilized cancellous bone allograft | 1–2 |
8 Weeks | 12 Weeks | |||
Group | Mean | SD | Mean | SD |
Control | 34.81 | 7.98 | 44.80 | 0.60 |
Synthetic | 34.11 | 20.21 | 47.25 | 1.12 |
Bovine | 32.08 | 11.95 | 39.14 | 1.10 |
Human | 29.20 | 9.55 | 35.08 | 0.93 |
Group comparison | p value | |||
8 weeks | 12 weeks | |||
Control Synthetic | 0.858 | 0.005 | ||
Control Human | 0.179 | 0.001 | ||
Control Bovine | 0.541 | 0.001 | ||
Synthetic Bovine | 0.693 | 0.002 | ||
Synthetic Human | 0.315 | 0.001 | ||
Bovine Human | 0.583 | 0.001 |
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Titsinides, S.; Karatzas, T.; Perrea, D.; Eleftheriadis, E.; Podaropoulos, L.; Kalyvas, D.; Katopodis, C.; Agrogiannis, G. Osseous Healing in Surgically Prepared Bone Defects Using Different Grafting Materials: An Experimental Study in Pigs. Dent. J. 2020, 8, 7. https://doi.org/10.3390/dj8010007
Titsinides S, Karatzas T, Perrea D, Eleftheriadis E, Podaropoulos L, Kalyvas D, Katopodis C, Agrogiannis G. Osseous Healing in Surgically Prepared Bone Defects Using Different Grafting Materials: An Experimental Study in Pigs. Dentistry Journal. 2020; 8(1):7. https://doi.org/10.3390/dj8010007
Chicago/Turabian StyleTitsinides, Savvas, Theodore Karatzas, Despoina Perrea, Efstathios Eleftheriadis, Leonidas Podaropoulos, Demos Kalyvas, Christos Katopodis, and George Agrogiannis. 2020. "Osseous Healing in Surgically Prepared Bone Defects Using Different Grafting Materials: An Experimental Study in Pigs" Dentistry Journal 8, no. 1: 7. https://doi.org/10.3390/dj8010007