Multi-Omics Analyses Reveal the Mechanisms of Early Stage Kidney Toxicity by Diquat
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals and Chemical Reagents Treatments
2.2. Histopathologic Examination
2.3. Transcriptome Analysis
2.4. Proteomics Analysis
2.5. Untargeted LC–MS Metabolomics Analysis
2.6. Statistical Analysis
3. Results
3.1. Establishment and Validation of DQ-Treated Mouse Model
3.2. Transcriptomic Analysis of DQ-Treated Mice
3.3. Proteomic Analysis of DQ-Treated Mice
3.4. Integrated Transcriptome and Proteome Datasets
3.5. Metabolomic Analysis of DQ-Treated Mice
3.6. Integrated Transcriptomic, Proteomic and Metabolomics
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Zhang, H.; Zhang, J.; Li, J.; Mao, Z.; Qian, J.; Zong, C.; Sun, H.; Yuan, B. Multi-Omics Analyses Reveal the Mechanisms of Early Stage Kidney Toxicity by Diquat. Toxics 2023, 11, 184. https://doi.org/10.3390/toxics11020184
Zhang H, Zhang J, Li J, Mao Z, Qian J, Zong C, Sun H, Yuan B. Multi-Omics Analyses Reveal the Mechanisms of Early Stage Kidney Toxicity by Diquat. Toxics. 2023; 11(2):184. https://doi.org/10.3390/toxics11020184
Chicago/Turabian StyleZhang, Huazhong, Jinsong Zhang, Jinquan Li, Zhengsheng Mao, Jian Qian, Cheng Zong, Hao Sun, and Beilei Yuan. 2023. "Multi-Omics Analyses Reveal the Mechanisms of Early Stage Kidney Toxicity by Diquat" Toxics 11, no. 2: 184. https://doi.org/10.3390/toxics11020184