Ferroptosis as a Potential Therapeutic Target of Traditional Chinese Medicine for Mycotoxicosis: A Review
Abstract
:1. Introduction
2. Mechanisms of Ferroptosis
2.1. Iron Metabolism
2.2. Lipid Metabolism
2.3. System Xc-/GPX4 Pathway Regulation
2.4. Mitochondrion-Mediated Ferroptosis
3. Role of Ferroptosis in Mycotoxicosis Diseases
3.1. AFB1 and Ferroptosis
3.2. Zearalenone and Ferroptosis
3.3. T-2 Toxin and Ferroptosis
3.4. Patulin and Ferroptosis
4. Chinese Herbal Medicine for Ferroptosis-Mediated Mycotoxin Poisoning
4.1. Regulation of Ferroptosis by Chinese Herbal Medicines
4.2. Treatment of Mycotoxin Poisoning by Chinese Herbal Medicine
4.3. Chinese Herbal Medicine for the Treatment of Mycotoxin Poisoning Mediated by the Ferroptosis Pathway
5. Conclusions and Perspective Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
References
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Chinese Herbal Medicines | Active Ingredient | Organ/Cell | Disease Model/Target | References |
---|---|---|---|---|
Lycopene | Carotenoids | Jejunal tissues | Murine model of multiple-mycotoxin exposure | Lin et al. [16] |
Fucoidan | Polysaccharides | Liver tissues | Murine model of alcohol exposure | Xue et al. [29] |
Flavonoid 4,4′-dimethoxychalcone | Flavonoids | A549 cells and 786-O cells and 293T cells | Keap1/Nrf2/HMOX1 pathway | Yang et al. [34] |
Terpenoid | Artemisinin | Hepatocellular carcinoma cells and glioblastoma cells | GSH or GPX4 | Wu et al. [84] |
Lycopene | Carotenoids | Spleen tissues | Murine model of DEHP exposure | Dai et al. [85] |
morachalcone D | Flavonoids | HT22 cells | Erastin-induced cell death | Wen et al. [86] |
Artesunate | Artemisinin | HNC cells | Nrf2–ARE antioxidant signaling pathway | Roh et al. [87] |
Curcumin Nanoparticles | Polyphenols | MDCK cells and HT22 cells | Murine model of Intracerebral Hemorrhage | Yang et al. [88] |
Curcumin | Polyphenols | Human BC cell lines | Murine model of breast cancer | Cao et al. [89] |
Chinese Herbal Medicines | Active Ingredient | Mycotoxins | Mechanisms | Organ/Cell | References |
---|---|---|---|---|---|
Marine algal polysaccharides | Polysaccharides | AFB1 | p38MAPK-Nrf2/HO-1 and mitochondrial apoptotic signaling pathway | Bursa of Fabricius in broilers | Guo et al. [13] |
Curcumin | Polyphenols | AFB1 | Upregulation of Nrf2/HO-1 signaling pathway and suppression of ROS and AFB1-adducts production | Liver in chickens | Li et al. [48] |
AFB1 | Involve the expression of LncRNAs | Liver in broilers | Li et al. [83] | ||
Lycopene | Carotenoids | AFB1 | Enhance antioxidant capacity by activating Nrf2 signaling pathway | Liver in murine | Xu et al. [90] |
AFB1 | Enhancement of spleen antioxidant ability and inhibition of lymphocytes apoptosis | Spleen in murine | Xu et al. [91] | ||
Fucoidan | Polysaccharides | AFB1 | Restore the hepatorenal markers and enhance the antioxidant enzyme activity | Liver and kidneys in murine | Abdel-Daim et al. [94] |
Milk thistle | Flavonoids | AFB1 | Restore the hepatic markers | Liver in meat-type chicken | Din et al. [95] |
Curcumin | Polyphenols | AFB1 | Relate to antioxidant response, defense response, and inflammation | Bovine fetal hepatocytes | Pauletto et al. [96] |
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Ding, W.; Lin, L.; Yue, K.; He, Y.; Xu, B.; Shaukat, A.; Huang, S. Ferroptosis as a Potential Therapeutic Target of Traditional Chinese Medicine for Mycotoxicosis: A Review. Toxics 2023, 11, 395. https://doi.org/10.3390/toxics11040395
Ding W, Lin L, Yue K, He Y, Xu B, Shaukat A, Huang S. Ferroptosis as a Potential Therapeutic Target of Traditional Chinese Medicine for Mycotoxicosis: A Review. Toxics. 2023; 11(4):395. https://doi.org/10.3390/toxics11040395
Chicago/Turabian StyleDing, Wenli, Luxi Lin, Ke Yue, Yanfeng He, Bowen Xu, Aftab Shaukat, and Shucheng Huang. 2023. "Ferroptosis as a Potential Therapeutic Target of Traditional Chinese Medicine for Mycotoxicosis: A Review" Toxics 11, no. 4: 395. https://doi.org/10.3390/toxics11040395