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Volume 11
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10.3390/toxics11050424
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Article

Associations between Air Pollution Exposure and Blood Pressure during Pregnancy among PRINCESA Cohort Participants

by
Miatta A. Buxton
1,*,
Safa Heydarzadeh
1,
Carina J. Gronlund
1,2,
Marisol Castillo-Castrejon
3,
Myrna Souraye Godines-Enriquez
4,
Marie S. O’Neill
1,5 and
Felipe Vadillo-Ortega
5,6
1
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
2
Institute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI 48104, USA
3
Department of Pathology, Stephenson Cancer Center, Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
4
Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City 11000, Mexico
5
Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
6
Unidad de Vinculación Científica de la Facultad de Medicina, Universidad Nacional Autónoma de México en el Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico
*
Author to whom correspondence should be addressed.
Toxics 2023, 11(5), 424; https://doi.org/10.3390/toxics11050424
Submission received: 31 December 2022 / Revised: 12 April 2023 / Accepted: 19 April 2023 / Published: 3 May 2023
(This article belongs to the Special Issue Ambient Air Pollution Exposure and Human Health)
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Abstract

High blood pressure (BP) is a risk factor for hypertensive disease during pregnancy. Exposure to multiple toxic air pollutants can affect BP in pregnancy but has been rarely studied. We evaluated trimester-specific associations between air pollution exposure and systolic (SBP) and diastolic BP (DBP). Ozone (O3), sulfur dioxide (SO2), carbon monoxide (CO), nitrogen dioxide (NO2), and particulate matter less than 10 and 2.5 μm in aerodynamic diameter (PM10, PM2.5) in the Pregnancy Research on Inflammation, Nutrition, & City Environment: Systematic Analyses (PRINCESA) study. Multipollutant generalized linear regression models with each pollutant and O3 were fit. Due to nonlinear pollution/BP associations, results are presented for “below the median” or “above the median”, where the beta estimate is the change in BP at a pollutant’s median versus BP at the pollutant’s minimum or maximum, respectively. Associations varied across trimesters and pollutants, and deleterious associations (higher blood pressure with higher pollution) were found only at pollutant values below the median: for SBP with NO2 in the second and third trimesters, and PM2.5 during the third trimester, and for DBP, PM2.5, and NO2 in the second and third trimesters. Findings suggest that minimizing prenatal exposure to air pollution may reduce the risks of changes in BP.
Keywords: maternal health; ambient air pollution; trimester-specific exposure; blood pressure; cardiovascular health risks maternal health; ambient air pollution; trimester-specific exposure; blood pressure; cardiovascular health risks

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MDPI and ACS Style

Buxton, M.A.; Heydarzadeh, S.; Gronlund, C.J.; Castillo-Castrejon, M.; Godines-Enriquez, M.S.; O’Neill, M.S.; Vadillo-Ortega, F. Associations between Air Pollution Exposure and Blood Pressure during Pregnancy among PRINCESA Cohort Participants. Toxics 2023, 11, 424. https://doi.org/10.3390/toxics11050424

AMA Style

Buxton MA, Heydarzadeh S, Gronlund CJ, Castillo-Castrejon M, Godines-Enriquez MS, O’Neill MS, Vadillo-Ortega F. Associations between Air Pollution Exposure and Blood Pressure during Pregnancy among PRINCESA Cohort Participants. Toxics. 2023; 11(5):424. https://doi.org/10.3390/toxics11050424

Chicago/Turabian Style

Buxton, Miatta A., Safa Heydarzadeh, Carina J. Gronlund, Marisol Castillo-Castrejon, Myrna Souraye Godines-Enriquez, Marie S. O’Neill, and Felipe Vadillo-Ortega. 2023. "Associations between Air Pollution Exposure and Blood Pressure during Pregnancy among PRINCESA Cohort Participants" Toxics 11, no. 5: 424. https://doi.org/10.3390/toxics11050424

APA Style

Buxton, M. A., Heydarzadeh, S., Gronlund, C. J., Castillo-Castrejon, M., Godines-Enriquez, M. S., O’Neill, M. S., & Vadillo-Ortega, F. (2023). Associations between Air Pollution Exposure and Blood Pressure during Pregnancy among PRINCESA Cohort Participants. Toxics, 11(5), 424. https://doi.org/10.3390/toxics11050424

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