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Volume 12
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Article

Positive Association of Urinary Dimethylarsinic Acid (DMAV) with Serum 25(OH)D in Adults Living in an Area of Water-Borne Arsenicosis in Shanxi, China

by
Kunyu Zhang
1,2,
Yunyi Yin
1,2,
Man Lv
1,2,
Xin Zhang
1,2,
Meichen Zhang
1,2,
Jia Cui
1,2,
Ziqiao Guan
1,2,
Xiaona Liu
1,2,
Yang Liu
1,2,
Yanhui Gao
1,2,* and
Yanmei Yang
1,2,*
1
Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, China
2
Key Laboratory of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health of P. R. China, Harbin Medical University, Harbin 150081, China
*
Authors to whom correspondence should be addressed.
Toxics 2024, 12(1), 83; https://doi.org/10.3390/toxics12010083
Submission received: 18 October 2023 / Revised: 12 January 2024 / Accepted: 15 January 2024 / Published: 18 January 2024
(This article belongs to the Special Issue Environmental Arsenic Exposure, Toxicity Mechanism and Its Contribution to Human Diseases)
Versions Notes

Abstract

Limited studies have demonstrated that inorganic arsenic exposure is positively associated with serum vitamin D levels, although the correlation between urinary arsenic species and serum vitamin D has not been investigated in areas of water-borne arsenicosis. A cross-sectional study of 762 participants was conducted in Wenshui Country, Shanxi Province, a water-borne arsenicosis area. The results showed a positive relationship between urinary arsenic species (inorganic arsenic (iAs), methylarsonic acid (MMAV), dimethylarsinic acid (DMAV) and serum 25(OH)D. Log-binomial regression analysis indicated a 0.4% increase in the risk of vitamin D excess for every 1-unit increment in the Box–Cox transformed urinary DMAV after adjustment for covariates. After stratifying populations by inorganic arsenic methylation metabolic capacity, serum 25(OH)D levels in the populations with iAs% above the median and primary methylation index (PMI) below the median increased by 0.064 ng/mL (95% CI: 0.032 to 0.096) for every one-unit increase in the Box–Cox transformed total arsenic (tAs) levels. Serum 25(OH)D levels increased by 0.592 ng/mL (95% CI: 0.041 to 1.143) for every one-unit rise in the Box–Cox transformed iAs levels in people with skin hyperkeratosis. Overall, our findings support a positive relationship between urinary arsenic species and serum 25(OH)D. It was recommended that those residing in regions with water-borne arsenicosis should take moderate vitamin D supplements to avoid vitamin D poisoning.
Keywords: arsenic; serum 25(OH)D; methylation capacity; skin hyperkeratosis arsenic; serum 25(OH)D; methylation capacity; skin hyperkeratosis

Share and Cite

MDPI and ACS Style

Zhang, K.; Yin, Y.; Lv, M.; Zhang, X.; Zhang, M.; Cui, J.; Guan, Z.; Liu, X.; Liu, Y.; Gao, Y.; et al. Positive Association of Urinary Dimethylarsinic Acid (DMAV) with Serum 25(OH)D in Adults Living in an Area of Water-Borne Arsenicosis in Shanxi, China. Toxics 2024, 12, 83. https://doi.org/10.3390/toxics12010083

AMA Style

Zhang K, Yin Y, Lv M, Zhang X, Zhang M, Cui J, Guan Z, Liu X, Liu Y, Gao Y, et al. Positive Association of Urinary Dimethylarsinic Acid (DMAV) with Serum 25(OH)D in Adults Living in an Area of Water-Borne Arsenicosis in Shanxi, China. Toxics. 2024; 12(1):83. https://doi.org/10.3390/toxics12010083

Chicago/Turabian Style

Zhang, Kunyu, Yunyi Yin, Man Lv, Xin Zhang, Meichen Zhang, Jia Cui, Ziqiao Guan, Xiaona Liu, Yang Liu, Yanhui Gao, and et al. 2024. "Positive Association of Urinary Dimethylarsinic Acid (DMAV) with Serum 25(OH)D in Adults Living in an Area of Water-Borne Arsenicosis in Shanxi, China" Toxics 12, no. 1: 83. https://doi.org/10.3390/toxics12010083

APA Style

Zhang, K., Yin, Y., Lv, M., Zhang, X., Zhang, M., Cui, J., Guan, Z., Liu, X., Liu, Y., Gao, Y., & Yang, Y. (2024). Positive Association of Urinary Dimethylarsinic Acid (DMAV) with Serum 25(OH)D in Adults Living in an Area of Water-Borne Arsenicosis in Shanxi, China. Toxics, 12(1), 83. https://doi.org/10.3390/toxics12010083

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