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Medicines, Volume 5, Issue 4

2018 December - 29 articles

Cover Story: This review reports the advantages of nano-delivery systems, which have been developed to protect the curcumin substance from degradation and improve its bioavailability. Curcumin is a natural polyphenolic compound from the root of Curcuma Longa L. Its consumption as a nutraceutical increases because of its antioxidant and anti-inflammatory properties. Several in vitro and in vivo studies have demonstrated the neuroprotective potential of curcumin in different neurodegenerative disease models. Curcumin has limited water-solubility, which presents obstacles for successful clinical trials with Alzheimer’s disease patients. Therefore, the considered here lipid-based nanoparticles and polymeric carriers offer new opportunities for curcumin delivery and enhancing its bioavailiability in pharmaceutical applications. View this paper.
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Articles (29)

  • Article
  • Open Access
16 Citations
5,351 Views
9 Pages

A New Approach for Indexing Honey for Its Heath/Medicinal Benefits: Visualization of the Concept by Indexing Based on Antioxidant and Antibacterial Activities

  • Mahmud Masalha,
  • Saleh Abu-Lafi,
  • Basheer Abu-Farich,
  • Mahmoud Rayan,
  • Nael Issa,
  • Mouhammad Zeidan and
  • Anwar Rayan

17 December 2018

Background: The goals of the current study were to address a new concept termed a health benefits’ index (HBI) and to verify the type of correlation between the pricing of honey and its HBI/medicinal properties. Diverse types of honey from diff...

  • Article
  • Open Access
16 Citations
7,709 Views
10 Pages

16 December 2018

Background: The parents of preterm infants face major mental health challenges in the Neonatal Intensive Care Unit (NICU). Family-centered music therapy actively integrates and empowers parents in their infants’ care. With the aim to better und...

  • Article
  • Open Access
10 Citations
4,518 Views
13 Pages

Knockdown of Gene Expression in Macrophages by microRNA Mimic-Containing Poly (Lactic-co-glycolic Acid) Microparticles

  • Paul J. McKiernan,
  • Patrick Lynch,
  • Joanne M. Ramsey,
  • Sally Ann Cryan and
  • Catherine M. Greene

15 December 2018

Background: microRNA (miRNA) regulate target gene expression through translational repression and/or mRNA degradation and are involved in the regulation of inflammation. Macrophages are key inflammatory cells that are important in chronic inflammator...

  • Editorial
  • Open Access
9 Citations
12,743 Views
5 Pages

12 December 2018

This editorial describes a new hypothesis concerning the nature and possible mechanisms of the Nogier reflex or reflex auriculo-cardiac (RAC; also vascular autonomic signal VAS). A multimodal concept for future RAC research is proposed.

  • Review
  • Open Access
51 Citations
10,742 Views
12 Pages

11 December 2018

The fields of radiotherapy and clinical oncology have been rapidly changed by the advances of technology. Improvement in computer processing power and imaging quality heralded precision radiotherapy allowing radiotherapy to be delivered efficiently,...

  • Review
  • Open Access
14 Citations
7,909 Views
12 Pages

Kampo (Traditional Japanese Herbal) Formulae for Treatment of Stomatitis and Oral Mucositis

  • Masataka Sunagawa,
  • Kojiro Yamaguchi,
  • Mana Tsukada,
  • Nachi Ebihara,
  • Hideshi Ikemoto and
  • Tadashi Hisamitsu

10 December 2018

Stomatitis is occasionally multiple, recurrent, and refractory. Currently, mucositis induced by chemotherapy and radiation therapy in patients with cancer has become a significant clinical problem. Effective treatments have not been established and t...

  • Article
  • Open Access
12 Citations
5,072 Views
9 Pages

3 December 2018

Background: The genera Abiotrophia and Granulicatella, previously known as nutritionally variant streptococci (NVS), are fastidious bacteria requiring vitamin B6 analogs for growth. They are members of human normal oral microbiota, and are supposed t...

  • Article
  • Open Access
11 Citations
4,634 Views
10 Pages

Association of Dietary Advanced Glycation End Products with Metabolic Syndrome in Young Mexican Adults

  • Kenny Mendoza-Herrera,
  • Celia Aradillas-García,
  • Miguel A. Mejía-Diaz,
  • Jorge A. Alegría-Torres,
  • Ma. Eugenia Garay-Sevilla and
  • Claudia Luevano-Contreras

1 December 2018

Background: Consumption of dietary advanced glycation end products is linked to metabolic syndrome. The objective was to describe the association between dietary advanced glycation end products intake and metabolic syndrome in young Mexican adults. M...

  • Review
  • Open Access
64 Citations
8,054 Views
21 Pages

23 November 2018

Neurodegenerative diseases have become a major challenge for public health because of their incurable status. Soft nanotechnology provides potential for slowing down the progression of neurodegenerative disorders by using innovative formulations of n...

  • Review
  • Open Access
47 Citations
11,018 Views
13 Pages

23 November 2018

Nelumbo nucifera Gaertn. has been used as an important ingredient for traditional medicines since ancient times, especially in Asian countries. Nowadays, many new or unknown phytochemical compounds from N. nucifera are still being discovered. Most of...

  • Review
  • Open Access
28 Citations
7,214 Views
13 Pages

The Role of Zwitterionic Materials in the Fight against Proteins and Bacteria

  • Montserrat Colilla,
  • Isabel Izquierdo-Barba and
  • María Vallet-Regí

22 November 2018

Zwitterionization of biomaterials has been heightened to a potent tool to develop biocompatible materials that are able to inhibit bacterial and non-specific proteins adhesion. This constitutes a major progress in the biomedical field. This manuscrip...

  • Article
  • Open Access
17 Citations
4,425 Views
12 Pages

21 November 2018

Background: Thioredoxin (TRX) acts as both a scavenger of reactive oxygen species (ROS) and an immuno-modulator. Although quercetin has been shown to favorably modify allergic rhinitis (AR) symptoms, its influence on TRX production is not well define...

  • Feature Paper
  • Review
  • Open Access
22 Citations
6,300 Views
24 Pages

The Biological Efficacy of Natural Products against Acute and Chronic Inflammatory Diseases in the Oral Region

  • Toshiaki Ara,
  • Sachie Nakatani,
  • Kenji Kobata,
  • Norio Sogawa and
  • Chiharu Sogawa

13 November 2018

The oral inflammatory diseases are divided into two types: acute and chronic inflammatory diseases. In this review, we summarize the biological efficacy of herbal medicine, natural products, and their active ingredients against acute and chronic infl...

  • Article
  • Open Access
28 Citations
5,387 Views
18 Pages

13 November 2018

Background: We studied the effect of three plant extracts (Glycyrrhiza glabra, Paeonia lactiflora, Eriobotrya japonica) and six of their major secondary metabolites (glycyrrhizic acid, 18β glycyrrhetinic acid, liquiritigenin, isoliquiritigenin,...

  • Feature Paper
  • Review
  • Open Access
22 Citations
8,137 Views
18 Pages

12 November 2018

Many viruses, such as human herpesviruses, may be present in the human oral cavity, but most are usually asymptomatic. However, if individuals become immunocompromised by age, illness, or as a side effect of therapy, these dormant viruses can be acti...

  • Feature Paper
  • Review
  • Open Access
24 Citations
24,394 Views
81 Pages

12 November 2018

Background: Native Americans have had a rich ethnobotanical heritage for treating diseases, ailments, and injuries. Cherokee traditional medicine has provided numerous aromatic and medicinal plants that not only were used by the Cherokee people, but...

  • Article
  • Open Access
25 Citations
7,372 Views
14 Pages

2 November 2018

Background: Older adults have fewer physiological reserves and are more likely to be affected by stress. Mindfulness meditation has the potential to be an effective treatment for depression, but little research has been conducted on older adults. The...

  • Review
  • Open Access
5 Citations
5,205 Views
17 Pages

New Functions of Classical Compounds against Orofacial Inflammatory Lesions

  • Norifumi H. Moritani,
  • Emilio Satoshi Hara and
  • Satoshi Kubota

1 November 2018

Anti-inflammatory agents have been widely used to ameliorate severe inflammatory symptoms of a number of diseases, and such therapeutics are particularly useful for diseases with intolerable pain without significant mortality. A typical example of th...

  • Article
  • Open Access
7 Citations
4,232 Views
19 Pages

Changes in Metabolic Profiles of Human Oral Cells by Benzylidene Ascorbates and Eugenol

  • Hiroshi Sakagami,
  • Masahiro Sugimoto,
  • Yumiko Kanda,
  • Yukio Murakami,
  • Osamu Amano,
  • Junko Saitoh and
  • Atsuko Kochi

31 October 2018

Background: Sodium-5,6-benzylidene-L-ascorbate (SBA), and its component units, benzaldehyde (BA) and sodium ascorbate (SA), are known to exert antitumor activity, while eugenol exerts anti-inflammatory activity. To narrow down their intracellular tar...

  • Article
  • Open Access
8 Citations
5,230 Views
14 Pages

Anti-Plasmodium falciparum Activity of Extracts from 10 Cameroonian Medicinal Plants

  • Toghueo Kouipou Rufin Marie,
  • Heroine Mbetyoumoun Mfouapon,
  • Eugenie Aimée Madiesse Kemgne,
  • Cedric Derick Jiatsa Mbouna,
  • Patrick Valere Tsouh Fokou,
  • Dinkar Sahal and
  • Fabrice Fekam Boyom

29 October 2018

Background: In the midst of transient victories by way of insecticides against mosquitoes or drugs against malaria, the most serious form of malaria, caused by Plasmodium falciparum, continues to be a major public health problem. The emergence of dru...

  • Review
  • Open Access
17 Citations
7,428 Views
30 Pages

Checkpoint Inhibition: Will Combination with Radiotherapy and Nanoparticle-Mediated Delivery Improve Efficacy?

  • Purushottam Lamichhane,
  • Neha P. Amin,
  • Manuj Agarwal and
  • Narottam Lamichhane

23 October 2018

Checkpoint inhibition (CPI) has been a rare success story in the field of cancer immunotherapy. Knowledge gleaned from preclinical studies and patients that do not respond to these therapies suggest that the presence of tumor-infiltrating lymphocytes...

  • Case Report
  • Open Access
1 Citations
3,542 Views
5 Pages

22 October 2018

Background: Selective serotonin reuptake inhibitors are a very common choice of antidepressive drug-therapy during pregnancy. In up to 30% of cases, they have been found to cause neonatal abstinence syndrome in newborn infants. Although often both ti...

  • Review
  • Open Access
63 Citations
9,839 Views
15 Pages

21 October 2018

Since ancient times, plants have been used to preserve food, or for their health properties. Essential oils are complex mixtures of volatile compounds that are obtained from botanical material, specifically from aromatic plants. Lamiaceae is one of t...

  • Article
  • Open Access
1 Citations
4,407 Views
11 Pages

Effects of Reflective Labyrinth Walking Assessed Using a Questionnaire

  • Daniele S. Lizier,
  • Reginaldo Silva-Filho,
  • Juliane Umada,
  • Romualdo Melo and
  • Afonso Carlos Neves

17 October 2018

Background: Meditation as it is currently known is an ancient practice, which can be traced back to Asian traditions. With the proper technique, a state of physical relaxation and respiratory balance can be reached naturally and spontaneously. This p...

  • Article
  • Open Access
19 Citations
5,151 Views
9 Pages

Citrus limon Extract Loaded in Vesicular Systems for the Protection of Oral Cavity

  • Maria Manconi,
  • Maria Letizia Manca,
  • Carla Caddeo,
  • Giorgia Sarais,
  • Alessandra Palmieri,
  • Guy D’Hallewin and
  • Anna Maria Fadda

14 October 2018

Background: The nanoincorporation of the extract of Citrus limon (L.) Osbeck var. pompia into liposomes was aimed at improving its antioxidant and antibacterial effects. Methods: The extract of the rind of Citrus limon (L.) Osbeck var. pompia was obt...

  • Review
  • Open Access
26 Citations
5,761 Views
18 Pages

Scabiosa Genus: A Rich Source of Bioactive Metabolites

  • Diana C. G. A. Pinto,
  • Naima Rahmouni,
  • Noureddine Beghidja and
  • Artur M. S. Silva

9 October 2018

The genus Scabiosa (family Caprifoliaceae) is considered large (618 scientific plant names of species) although only 62 have accepted Latin binominal names. The majority of the Scabiosa species are widely distributed in the Mediterranean region and s...

  • Brief Report
  • Open Access
46 Citations
13,383 Views
8 Pages

8 October 2018

The growing population of people with dementia worldwide calls attention to the burdens associated with age-related decline that affects physiology, psychological and cognitive status, and social/emotional wellbeing. The current standards in geriatri...

  • Feature Paper
  • Review
  • Open Access
27 Citations
16,118 Views
17 Pages

New Perspectives on the Use of Cannabis in the Treatment of Psychiatric Disorders

  • Maria Scherma,
  • Paolo Masia,
  • Matteo Deidda,
  • Walter Fratta,
  • Gianluigi Tanda and
  • Paola Fadda

2 October 2018

Following the discovery of the endocannabinoid system and its potential as a therapeutic target for various pathological conditions, growing interest led researchers to investigate the role of cannabis and its derivatives for medical purposes. The co...

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Medicines - ISSN 2305-6320