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Medicines, Volume 9, Issue 6

2022 June - 4 articles

Cover Story: In this investigation, hybrid molecules were formed which include the structural features of cytotoxic 3.5-bis(benzylidene)-4-piperidones (considered to be alkylators) and dichloroacetic acid, which inhibits pyruvate dehydrogenase kinase 1. The compounds are highly toxic to several neoplasms (CC₅₀ values less than 1 µM) and much less toxic to three non-malignant cell lines. These observations reveal that these hybrid molecules demonstrate tumor-selective toxicity. The mode of action of representative compounds using Ca9-22 cells includes G2/M arrest, causing cells to undergo mitosis and cleavage of both PARP and procaspase-3. View this paper

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Commentary

5 Citations

3,258 Views

9 Pages

The Sweet Side of Fungal Infections: Structural Glycan Diversity and Its Importance for Pathogenic Adaptation

Israel Diniz-Lima,
Leonardo Marques da Fonseca,
Jhenifer Santos dos Reis,
Marcos André Rodrigues da Costa Santos,
Kelli Monteiro da Costa,
Carlos Antonio do Nascimento Santos,
Pedro Marçal Barcelos,
Kamila Guimarães-Pinto,
Alessandra Almeida Filardy and
Leonardo Freire-de-Lima
+ 4 authors

Medicines2022, 9(6), 37;https://doi.org/10.3390/medicines9060037

16 June 2022

Fungal infections are the most common secondary infections in debilitated individuals in a state of chronic disease or immunosuppression. Despite this, most fungal infections are neglected, mainly due to the lower frequency of their more severe clini...

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Article

3 Citations

2,975 Views

15 Pages

Potential Role of Certain Biomarkers Such as Vitamin B12, ROS, Albumin, as Early Predictors for Prognosis of COVID-19 Outcomes

Evgenia Lymperaki,
Konstantina Kazeli,
Georgia Variti,
Magda Gerothanasi,
Argyrios Gkinoudis,
Ioannis Tsamesidis and
Eleni Vagdatli

Medicines2022, 9(6), 36;https://doi.org/10.3390/medicines9060036

15 June 2022

COVID-19 disease is still a major global concern because of its morbidity and its mortality in severe disease. Certain biomarkers including Reactive Oxygen Species (ROS), vitamins, and trace elements are known to play a crucial role in the pathophysi...

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Article

1 Citations

2,970 Views

11 Pages

Dichloroacetyl Amides of 3,5-Bis(benzylidene)-4-piperidones Displaying Greater Toxicity to Neoplasms than to Non-Malignant Cells

Mohammad Hossain,
Praveen K. Roayapalley,
Hiroshi Sakagami,
Keitaro Satoh,
Kenjiro Bandow,
Umashankar Das and
Jonathan R. Dimmock

Medicines2022, 9(6), 35;https://doi.org/10.3390/medicines9060035

8 June 2022

A series of 3,5-bis(benzylidene)-1-dichloroacetyl-4-piperidones 1a–l was evaluated against Ca9-22, HSC-2, HSC-3, and HSC-4 squamous cell carcinomas. Virtually all of the compounds displayed potent cytotoxicity, with 83% of the CC₅₀ values being...

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Opinion

7 Citations

3,619 Views

5 Pages

Glycobiology of Cancer: Sugar Drives the Show

Jhenifer Santos dos Reis,
Marcos André Rodrigues da Costa Santos,
Daniella Pereira Mendonça,
Stefani Ingrid Martins do Nascimento,
Pedro Marçal Barcelos,
Rafaela Gomes Correia de Lima,
Kelli Monteiro da Costa,
Celio Geraldo Freire-de-Lima,
Alexandre Morrot and
Leonardo Freire-de-Lima
+ 3 authors

Medicines2022, 9(6), 34;https://doi.org/10.3390/medicines9060034

24 May 2022

Cancer development and progression is associated with aberrant changes in cellular glycosylation. Cells expressing altered glycan-structures are recognized by cells of the immune system, favoring the induction of inhibitory immune processes which sub...

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