Adipose Tissue-Derived Components: From Cells to Tissue Glue to Treat Dermal Damage
Abstract
:1. Introduction
2. Regenerative Components of Adipose Tissue
3. The Extracellular Matrix as an Instructive Scaffold and Delivery Vehicle for Trophic Factors
4. Conclusions and Future Perspective
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Product | Benefits | Disadvantages/Challenges |
---|---|---|
Lipofilling | Large quantities; easy procedure; limited patient morbidity | Autologous; intra-operative procedure warranted; limited availability slim persons; fat graft retention unclear; influential intra-personal factors; specialized medicine |
Supplemented Lipofilling | Large quantities; easy procedure; limited patient morbidity; possibly better fat graft retention | Autologous; intra-operative procedure warranted; limited availability slim persons; fat graft retention unclear; influential intra-personal factors; specialized medicine |
Tissue-SVF | Fast, easy, cheap procedure; obtained 1. intra-operatively or 2. from donor tissue; application possibilities for small or medium sizes with high regenerative potential; dose-changeable | Autologous; quantity limited to available adipose tissue; mass cell death after defrosting; specialized medicine |
Cellular-SVF | Application possibilities for small or medium sizes with high regenerative potential; dose-changeable | Autologous; expensive, long procedure; chemical use; the need for lab facility, equipment; mass cell death after defrosting; storage; specialized medicine |
ASC | Multipotent cell differentiation; high regenerative potential; dose-changeable | Autologous; governmental approval; obtained 1. intra-operatively or 2. from donor tissue or lab culturing; the need for lab facility and equipment; mass cell death after defrosting; storage; specialized medicine |
ASC Secretome | Allogenic; dose-changeable; prolonged preservation; various medical indications; no patient morbidity; application possibilities of small, medium, and large sizes | Governmental approval; obtained 1. intra-operatively or 2. from donor tissue or lab culturing; the need for lab facility and equipment; experimental setting |
ECM hydrogels | Allogenic; dose-changeable; unlimited preservation; various medical indications; no patient morbidity; application possibilities of small, medium, and large sizes; availability in a large group of patients; specialized medicine and GP | Scalability; governmental approval; indications and therapeutic application not yet determined; experimental setting |
ECM hydrogels + ASC secretome | Allogenic; dose-changeable; unlimited preservation; various medical indications; no patient morbidity; application possibilities of small, medium, and large sizes; availability in a large group of patients; specialized medicine and GP | Scalability; governmental approval; Indications and therapeutic application not yet determined; experimental setting |
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Vriend, L.; van der Lei, B.; Harmsen, M.C.; van Dongen, J.A. Adipose Tissue-Derived Components: From Cells to Tissue Glue to Treat Dermal Damage. Bioengineering 2023, 10, 328. https://doi.org/10.3390/bioengineering10030328
Vriend L, van der Lei B, Harmsen MC, van Dongen JA. Adipose Tissue-Derived Components: From Cells to Tissue Glue to Treat Dermal Damage. Bioengineering. 2023; 10(3):328. https://doi.org/10.3390/bioengineering10030328
Chicago/Turabian StyleVriend, Linda, Berend van der Lei, Martin C. Harmsen, and Joris A. van Dongen. 2023. "Adipose Tissue-Derived Components: From Cells to Tissue Glue to Treat Dermal Damage" Bioengineering 10, no. 3: 328. https://doi.org/10.3390/bioengineering10030328