Chemical Shift-Encoded Sequence (IDEAL-IQ) and Amide Proton Transfer (APT) MRI for Prediction of Histopathological Factors of Rectal Cancer
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Subjects
2.2. MRscanning Protocols
2.3. Image Processing and Analysis
2.4. Histopathological Analysis
2.5. Statistical Analysis
3. Results
3.1. Clinic and Pathologic Characteristics of Studied Population
3.2. Inter-Observer Variability for Assessment of IDEAL-IQ and APT Imaging-Derived Parameters
3.3. Comparison of MR Parameters between Different Histopathological Features of Rectal Cancer
3.4. Association of PDFF, R2* and MTRasym (3.5 ppm) Parameters with T/N Stage, Tumor Grade, MRF and EMVI Status of Rectal Cancer
3.5. Correlation of IDEAL-IQ Derived Parameters with MTRasym (3.5 ppm) from APTWI
3.6. ROC Curve Analysis
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Parameters | T1-Weighted Imaging | T2-Weighted Imaging | DWI | IDEAL-IQ | APTWI |
---|---|---|---|---|---|
Sequence | FSE | FSE | EPI | GRE | EPI |
Orientation | Axial | Axial | Axial | Axial | Axial |
TR/TE (msec) | 500/11 | 5629/85 | 4000/75 | 5.9/2.6 | 4070/20 |
FOV (mm2) | 380 × 380 | 200 × 200 | 200 × 100 | 380 × 380 | 360 × 360 |
Matrix | 320 × 224 | 448 × 314 | 128 × 64 | 160 × 160 | 128 × 128 |
Slice thickness (mm) | 3 | 2 | 3 | 3.5 | 4 |
Flip angle (degree) | 111° | 111° | N/A | 3° | N/A |
Bandwidth (Hz) | 62.5 | 31.3 | 250 | 111.1 | 250 |
b-values (s/ mm2) | N/A | N/A | 0, 800 | N/A | N/A |
NEX | 2 | 4 | 12 | 0.5 | 1 |
Scan time (min:s) | 1:44 | 4:04 | 2:32 | 0:19 | 4:29 |
PDFF (%) | p-Value | R2* (Hz) | p-Value | MTRasym (%) | p-Value | |
---|---|---|---|---|---|---|
pT category | ||||||
T1+T2 (n = 18) | 3.18 ± 1.23 | <0.001 | 27.72 ± 5.95 | <0.001 | 1.91 ± 0.79 | <0.001 |
T3+T4 (n = 49) | 6.32 ± 1.06 | 38.71 ± 5.33 | 3.89 ± 2.32 | |||
pN category | ||||||
N0 (n = 31) | 4.33 ± 1.65 | <0.001 | 32.09 ± 7.22 | <0.001 | 2.92 ± 2.74 | 0.001 |
N1+N2 (n = 36) | 6.46 ± 1.21 | 38.92 ± 5.88 | 3.74 ± 1.55 | |||
Tumor grade | ||||||
G1+G2 (n = 44) | 4.83 ± 1.70 | <0.001 | 33.63 ± 7.15 | 0.002 | 2.95 ± 1.65 | 0.006 |
G3 (n = 23) | 6.71 ± 1.19 | 39.83 ± 5.93 | 4.15 ± 2.87 | |||
MRF | ||||||
Negative (n = 46) | 4.95 ± 1.81 | <0.001 | 34.29 ± 7.76 | 0.015 | 2.92 ± 2.43 | <0.001 |
Positive (n = 21) | 6.62 ± 1.04 | 38.97 ± 5.15 | 4.20 ± 1.27 | |||
EMVI | ||||||
Negative (n = 37) | 4.55 ± 1.68 | <0.001 | 33.01 ± 7.48 | 0.001 | 2.30 ± 0.80 | <0.001 |
Positive (n = 30) | 6.62 ± 1.22 | 39.15 ± 5.61 | 4.67 ± 2.66 |
Histological Features | PDFF (%) | R2* (Hz) | MTRasym (%) | |||
---|---|---|---|---|---|---|
r-Value | p-Value | r-Value | p-Value | r-Value | p-Value | |
pT category | 0.723 | <0.001 | 0.651 | <0.001 | 0.606 | <0.001 |
pN category | 0.619 | <0.001 | 0.492 | <0.001 | 0.413 | 0.001 |
Tumor grade | 0.507 | <0.001 | 0.385 | 0.001 | 0.337 | 0.005 |
MRF | 0.464 | <0.001 | 0.299 | 0.014 | 0.524 | <0.001 |
EMVI | 0.607 | <0.001 | 0.427 | <0.001 | 0.667 | <0.001 |
Parameter | PDFF (%) | R2* (Hz) | ||
---|---|---|---|---|
r-Value | p-Value | R-Value | p-Value | |
MTRasym (%) | 0.563 | <0.001 | 0.335 | 0.006 |
Parameters | AUC (95% CI) | Cutoff | Sensitivity (%) | Specificity (%) | Youden Index | p-Value |
---|---|---|---|---|---|---|
pT category | ||||||
PDFF | 0.971 (0.928–1.000) | 4.95 | 89.80 | 94.40 | 0.842 | <0.001 |
R2* MTRasym | 0.924 (0.849–0.999) 0.895 (0.799–0.990) | 31.85 1.98 | 95.90 100.00 | 77.80 72.20 | 0.737 0.722 | <0.001 <0.001 |
pN category | ||||||
PDFF | 0.858 (0.770–0.946) | 5.68 | 77.80 | 80.60 | 0.584 | <0.001 |
R2* MTRasym | 0.785 (0.672–0.898) 0.739 (0.616–0.861) | 35.15 2.96 | 77.80 66.70 | 74.20 77.40 | 0.520 0.441 | <0.001 0.001 |
Tumor grade | ||||||
PDFF | 0.808 (0.702–0.915) | 6.31 | 65.20 | 88.60 | 0.539 | <0.001 |
R2* MTRasym | 0.734 (0.611–0.857) 0.705 (0.581–0.828) | 38.88 2.30 | 60.90 82.60 | 81.80 56.80 | 0.427 0.394 | 0.002 0.006 |
MRF | ||||||
PDFF | 0.789 (0.682–0.895) | 5.57 | 90.50 | 60.90 | 0.513 | <0.001 |
R2* MTRasym | 0.686 (0.558–0.814) 0.826 (0.725–0.927) | 32.30 3.65 | 95.20 76.20 | 39.10 82.60 | 0.344 0.588 | 0.015 <0.001 |
EMVI | ||||||
PDFF | 0.852 (0.762–0.942) | 6.14 | 70.00 | 89.20 | 0.592 | <0.001 |
R2* MTRasym | 0.748 (0.630–0.865) 0.887 (0.808–0.967) | 32.30 3.81 | 96.70 70.00 | 48.60 97.30 | 0.453 0.673 | 0.001 <0.001 |
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Peng, Y.; Zou, X.; Chen, G.; Hu, X.; Shen, Y.; Hu, D.; Li, Z. Chemical Shift-Encoded Sequence (IDEAL-IQ) and Amide Proton Transfer (APT) MRI for Prediction of Histopathological Factors of Rectal Cancer. Bioengineering 2023, 10, 720. https://doi.org/10.3390/bioengineering10060720
Peng Y, Zou X, Chen G, Hu X, Shen Y, Hu D, Li Z. Chemical Shift-Encoded Sequence (IDEAL-IQ) and Amide Proton Transfer (APT) MRI for Prediction of Histopathological Factors of Rectal Cancer. Bioengineering. 2023; 10(6):720. https://doi.org/10.3390/bioengineering10060720
Chicago/Turabian StylePeng, Yang, Xianlun Zou, Gen Chen, Xuemei Hu, Yaqi Shen, Daoyu Hu, and Zhen Li. 2023. "Chemical Shift-Encoded Sequence (IDEAL-IQ) and Amide Proton Transfer (APT) MRI for Prediction of Histopathological Factors of Rectal Cancer" Bioengineering 10, no. 6: 720. https://doi.org/10.3390/bioengineering10060720