Early Degenerative Changes in a Spontaneous Osteoarthritis Model Assessed by Nanoindentation
Abstract
:1. Introduction
2. Materials and Methods
2.1. Specimen Preparation
2.2. Nanoindentation
2.3. Histological Assessment of Osteoarthritis
2.4. Immunohistochemistry
2.5. Statistical Analaysis
3. Results
3.1. Age-Associated Degeneration of Dunkin-Hartley Guinea Pig Joints
3.2. Mechanical Alterations to Articular Cartilage during Osteoarthritis Developmen
3.3. Mechanical Alterations to Mineralized Regions of Calcified Cartilage and Subchondral Bone
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Appendix A
References
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Davis, S.; Zekonyte, J.; Karali, A.; Roldo, M.; Blunn, G. Early Degenerative Changes in a Spontaneous Osteoarthritis Model Assessed by Nanoindentation. Bioengineering 2023, 10, 995. https://doi.org/10.3390/bioengineering10090995
Davis S, Zekonyte J, Karali A, Roldo M, Blunn G. Early Degenerative Changes in a Spontaneous Osteoarthritis Model Assessed by Nanoindentation. Bioengineering. 2023; 10(9):995. https://doi.org/10.3390/bioengineering10090995
Chicago/Turabian StyleDavis, Sarah, Jurgita Zekonyte, Aikaterina Karali, Marta Roldo, and Gordon Blunn. 2023. "Early Degenerative Changes in a Spontaneous Osteoarthritis Model Assessed by Nanoindentation" Bioengineering 10, no. 9: 995. https://doi.org/10.3390/bioengineering10090995