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Open AccessArticle
Comparison of Left Ventricular Function Derived from Subject-Specific Inverse Finite Element Modeling Based on 3D ECHO and Magnetic Resonance Images
by
Lei Fan
Lei Fan 1,
Jenny S. Choy
Jenny S. Choy 2,
Chenghan Cai
Chenghan Cai 1,
Shawn D. Teague
Shawn D. Teague 3,
Julius Guccione
Julius Guccione 4,
Lik Chuan Lee
Lik Chuan Lee 5 and
Ghassan S. Kassab
Ghassan S. Kassab 2,*
1
Joint Department of Biomedical Engineering, Marquette University and Medical College of Wisconsin, Milwaukee, WI 53233, USA
2
California Medical Innovations Institute, San Diego, CA 92121, USA
3
Department of Radiology, National Jewish Health, Denver, CO 80206, USA
4
Department of Surgery, University of California at San Francisco, San Francisco, CA 94143, USA
5
Department of Mechanical Engineering, Michigan State University, East Lansing, MI 48824, USA
*
Author to whom correspondence should be addressed.
Bioengineering 2024, 11(7), 735; https://doi.org/10.3390/bioengineering11070735 (registering DOI)
Submission received: 9 May 2024
/
Revised: 5 June 2024
/
Accepted: 15 July 2024
/
Published: 20 July 2024
Abstract
Three-dimensional echocardiography (3D ECHO) and magnetic resonance (MR) imaging are frequently used in patients and animals to evaluate heart functions. Inverse finite element (FE) modeling is increasingly applied to MR images to quantify left ventricular (LV) function and estimate myocardial contractility and other cardiac biomarkers. It remains unclear, however, as to whether myocardial contractility derived from the inverse FE model based on 3D ECHO images is comparable to that derived from MR images. To address this issue, we developed a subject-specific inverse FE model based on 3D ECHO and MR images acquired from seven healthy swine models to investigate if there are differences in myocardial contractility and LV geometrical features derived using these two imaging modalities. We showed that end-systolic and end-diastolic volumes derived from 3D ECHO images are comparable to those derived from MR images (𝑅2 = 0.805 and 0.969, respectively). As a result, ejection fraction from 3D ECHO and MR images are linearly correlated (R2= 0.977) with the limit of agreement (LOA) ranging from −17.95% to 45.89%. Using an inverse FE modeling to fit pressure and volume waveforms in subject-specific LV geometry reconstructed from 3D ECHO and MR images, we found that myocardial contractility derived from these two imaging modalities are linearly correlated with an R2 value of 0.989, a gradient of 0.895, and LOA ranging from −6.11% to 36.66%. This finding supports using 3D ECHO images in image-based inverse FE modeling to estimate myocardial contractility.
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MDPI and ACS Style
Fan, L.; Choy, J.S.; Cai, C.; Teague, S.D.; Guccione, J.; Lee, L.C.; Kassab, G.S.
Comparison of Left Ventricular Function Derived from Subject-Specific Inverse Finite Element Modeling Based on 3D ECHO and Magnetic Resonance Images. Bioengineering 2024, 11, 735.
https://doi.org/10.3390/bioengineering11070735
AMA Style
Fan L, Choy JS, Cai C, Teague SD, Guccione J, Lee LC, Kassab GS.
Comparison of Left Ventricular Function Derived from Subject-Specific Inverse Finite Element Modeling Based on 3D ECHO and Magnetic Resonance Images. Bioengineering. 2024; 11(7):735.
https://doi.org/10.3390/bioengineering11070735
Chicago/Turabian Style
Fan, Lei, Jenny S. Choy, Chenghan Cai, Shawn D. Teague, Julius Guccione, Lik Chuan Lee, and Ghassan S. Kassab.
2024. "Comparison of Left Ventricular Function Derived from Subject-Specific Inverse Finite Element Modeling Based on 3D ECHO and Magnetic Resonance Images" Bioengineering 11, no. 7: 735.
https://doi.org/10.3390/bioengineering11070735
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