In Vivo Testing of a Second-Generation Prototype Accessory for Single Transapical Left Ventricular Assist Device Implantation
Abstract
:1. Introduction
2. Materials and Methods
2.1. Device Design
2.2. Animal Testing
2.3. Surgical Procedure
2.4. Statistical Analysis
3. Results
3.1. Surgical Procedure
3.2. Hemodynamic Monitoring
3.3. Echocardiography
3.4. Hematology and Blood Chemistry
3.5. Post-Mortem Analysis
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Pre-CPB | LVAD | MD | p | |
---|---|---|---|---|
HR (bpm) | 101.0 ± 29.4 | 126.0 ± 29.2 | 25.0 | 0.032 |
SBP (mmHg) | 98.9 ± 19.8 | 96.4 ± 35.2 | −2.5 | 0.940 |
DBP (mmHg) | 59.7 ± 15.8 | 35.0 ± 27.7 | −24.7 | 0.018 |
MBP (mmHg) | 72.9 ± 14.7 | 55.8 ± 25.5 | −17.0 | 0.045 |
sPAP (mmHg) | 25.9 ± 5.6 | 31.0 ± 13.0 | 5.2 | 0.097 |
dPAP (mmHg) | 14.3 ± 3.9 | 20.1 ± 8.8 | 5.8 | 0.063 |
mPAP (mmHg) | 19.4 ± 4.1 | 25.4 ± 11.1 | 6.0 | 0.080 |
CVP (mmHg) | 9.4 ± 3.4 | 9.9 ± 4.3 | 0.5 | 0.321 |
CO (L/min) | 7.9 ± 2.3 | 5.5 ± 1.2 | −2.4 | 0.120 |
BT (°C) | 36.6 ± 1.1 | 35.3 ± 0.8 | −1.2 | 0.008 |
CCA flow (L/min) | 0.49 ± 0.17 | 0.30 ± 0.15 | −0.19 | 0.016 |
Flow (L/min) | 3.11 ± 1.28 | |||
Speed (rpm) | 5029 ± 892 |
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Meissner, F.; Galbas, M.C.; Straky, H.; Vestner, H.; Schoen, M.; Schimmel, M.; Reuter, J.; Buechsel, M.; Dinkelaker, J.; Cristina Schmitz, H.; et al. In Vivo Testing of a Second-Generation Prototype Accessory for Single Transapical Left Ventricular Assist Device Implantation. Bioengineering 2024, 11, 848. https://doi.org/10.3390/bioengineering11080848
Meissner F, Galbas MC, Straky H, Vestner H, Schoen M, Schimmel M, Reuter J, Buechsel M, Dinkelaker J, Cristina Schmitz H, et al. In Vivo Testing of a Second-Generation Prototype Accessory for Single Transapical Left Ventricular Assist Device Implantation. Bioengineering. 2024; 11(8):848. https://doi.org/10.3390/bioengineering11080848
Chicago/Turabian StyleMeissner, Florian, Michelle Costa Galbas, Hendrik Straky, Heiko Vestner, Manuela Schoen, Marius Schimmel, Johanna Reuter, Martin Buechsel, Johannes Dinkelaker, Heidi Cristina Schmitz, and et al. 2024. "In Vivo Testing of a Second-Generation Prototype Accessory for Single Transapical Left Ventricular Assist Device Implantation" Bioengineering 11, no. 8: 848. https://doi.org/10.3390/bioengineering11080848