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Bioengineering
Volume 9
Issue 7
10.3390/bioengineering9070285
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Review

Fusobacterium nucleatum and Malignant Tumors of the Digestive Tract: A Mechanistic Overview

by
Yue Lai
1,
Jun Mi
1,2,* and
Qiang Feng
1,*
1
Department of Human Microbiome, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, No. 44-1 Wenhua Road West, Jinan 250012, China
2
Shenzhen Research Institute of Shandong University, Shenzhen 518057, China
*
Authors to whom correspondence should be addressed.
Bioengineering 2022, 9(7), 285; https://doi.org/10.3390/bioengineering9070285
Submission received: 23 May 2022 / Revised: 20 June 2022 / Accepted: 24 June 2022 / Published: 28 June 2022
(This article belongs to the Special Issue Targeted Therapy for Cancer)
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Abstract

Fusobacterium nucleatum (F. nucleatum) is an oral anaerobe that plays a role in several oral diseases. However, F. nucleatum is also found in other tissues of the digestive tract, and several studies have recently reported that the level of F. nucleatum is significantly elevated in malignant tumors of the digestive tract. F. nucleatum is proposed as one of the risk factors in the initiation and progression of digestive tract malignant tumors. In this review, we summarize recent reports on F. nucleatum and its role in digestive tract cancers and evaluate the mechanisms underlying the action of F. nucleatum in digestive tract cancers.
Keywords: Fusobacterium nucleatum; oral squamous cell carcinoma; colorectal carcinoma; esophageal squamous cell carcinoma; pancreatic carcinoma Fusobacterium nucleatum; oral squamous cell carcinoma; colorectal carcinoma; esophageal squamous cell carcinoma; pancreatic carcinoma

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MDPI and ACS Style

Lai, Y.; Mi, J.; Feng, Q. Fusobacterium nucleatum and Malignant Tumors of the Digestive Tract: A Mechanistic Overview. Bioengineering 2022, 9, 285. https://doi.org/10.3390/bioengineering9070285

AMA Style

Lai Y, Mi J, Feng Q. Fusobacterium nucleatum and Malignant Tumors of the Digestive Tract: A Mechanistic Overview. Bioengineering. 2022; 9(7):285. https://doi.org/10.3390/bioengineering9070285

Chicago/Turabian Style

Lai, Yue, Jun Mi, and Qiang Feng. 2022. "Fusobacterium nucleatum and Malignant Tumors of the Digestive Tract: A Mechanistic Overview" Bioengineering 9, no. 7: 285. https://doi.org/10.3390/bioengineering9070285

APA Style

Lai, Y., Mi, J., & Feng, Q. (2022). Fusobacterium nucleatum and Malignant Tumors of the Digestive Tract: A Mechanistic Overview. Bioengineering, 9(7), 285. https://doi.org/10.3390/bioengineering9070285

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