Emerging Roles of Exocyst Complex in Fungi: A Review
Abstract
:1. Introduction
1.1. Overview of the Exocyst Complex
1.2. Importance of the Exocyst Complex in Fungi
2. Structural Composition of the Exocyst Complex in Fungi
2.1. Core Components of the Exocyst Complex
2.2. Interactions among the Exocyst Complex Subunits
2.3. Interactions of the Exocyst Complex with Regulatory Proteins
3. Comparison of the Exocyst Complex in Fungi and Other Model Organisms
3.1. Comparison of Exocyst Structure in Fungi and Model Organisms
3.2. Comparing Exocyst Localization in Fungi and Other Model Organisms
4. Regulation Mechanisms of the Exocyst Complex in Fungi
5. Roles of Fungal Exocyst Complex in Cellular Secretion
5.1. Exocyst Complex Promotes SNARE-Mediated Membrane Fusion
5.2. Exocyst-Mediated Vesicle Trafficking in Fungi
Exocyst Subunit | Interactor | Cellular Process | References |
---|---|---|---|
Sec3 | Rho1, Cdc42, Sso1/2, PI(4,5)P2 | Facilitates plasma membrane binding and SNARE assembly | [61,72,127] |
Sec5 | N/A * | Mediates the interaction of the two subcomplexes of exocyst | [23,135] |
Sec6 | Snc1/2, Sec1, Sec9 | Facilitates SNARE assembly. | [59,124,136] |
Sec8 | Rho3, Rho4 | Promote glucanase secretion to the proper area during a specific time in the cell cycle. | [137,138] |
Sec10 | N/A * | N/A * | |
Sec15 | Ypt31/32, Sec2, Sec4, Myo2 and Bem1 | [43,44,70,139,140] | |
Exo70 | Rho3, Cdc42, PI(4,5)P2 | [81,124,141] | |
Exo84 | Sro7/Sro77 | [125,127,135] |
5.3. Cargos of the Exocyst Complex
6. The Role of the Exocyst Complex in Polarized Growth
7. Role of the Exocyst Complex in Autophagy in Fungi
8. Roles of the Exocyst Complex in Mating and Ascospore Formation
9. The Role of the Exocyst Complex in Fungal Pathogenicity
10. Prevailing Challenges in Understanding the Exocyst Complex
11. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Exocyst Subunit | Function in Fungi | References |
---|---|---|
Sec3 | Marks the site of exocytosis and recruits the exocyst complex | [5,61,62] |
Sec5 | Involved in vesicle tethering and fusion | [11,63] |
Sec6 | Interacts with the SNARE complex to facilitate membrane fusion | [64,65] |
Sec8 | Stabilizes the exocyst complex and links it to the actin cytoskeleton | [11,28] |
Sec10 | Involved in vesicle tethering and fusion | [66,67] |
Sec15 | Links the exocyst to the Rab GTPase that marks the vesicle | [44,68] |
Exo70 | Interacts with the plasma membrane and the actin cytoskeleton | [69] |
Exo84 | Interacts with the Rab GTPase and helps tether the vesicle to the exocyst | [5,70] |
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Zuriegat, Q.; Abubakar, Y.S.; Wang, Z.; Chen, M.; Zhang, J. Emerging Roles of Exocyst Complex in Fungi: A Review. J. Fungi 2024, 10, 614. https://doi.org/10.3390/jof10090614
Zuriegat Q, Abubakar YS, Wang Z, Chen M, Zhang J. Emerging Roles of Exocyst Complex in Fungi: A Review. Journal of Fungi. 2024; 10(9):614. https://doi.org/10.3390/jof10090614
Chicago/Turabian StyleZuriegat, Qussai, Yakubu Saddeeq Abubakar, Zonghua Wang, Meilian Chen, and Jun Zhang. 2024. "Emerging Roles of Exocyst Complex in Fungi: A Review" Journal of Fungi 10, no. 9: 614. https://doi.org/10.3390/jof10090614