Antifungal Resistance: Specific Focus on Multidrug Resistance in Candida auris and Secondary Azole Resistance in Aspergillus fumigatus
Abstract
:1. Candida auris
1.1. Epidemiology and Risk Factors for Candida auris Infection
1.2. Virulence Factors of C. auris
1.3. C. auris Animal Models and Activity of Experimental Antifungals
1.4. Resistance of C. auris
2. Aspergillus fumigatus
2.1. Azole Resistance in A. fumigatus
2.2. Detection of Antifungal Resistance In Vitro by Reference Methods
2.3. Molecular Mechanisms Involved in Secondary Azole Resistance and the Resulting Azole Susceptibility Profiles
2.4. Acquisition of Secondary Azole Resistance
2.5. Clinical Implications and Current Recommendations for Treatment of Aspergillosis due to Azole-Resistant A. fumigatus
3. Concluding Remark
Author Contributions
Funding
Conflicts of Interest
References
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Associated Amino Acid Change/Tandem Repeat | Resistance | Reduced Susceptibility | Variable Susceptibility Profile |
---|---|---|---|
G54 | ITC, POS | ||
G138 | ITC, POS | ||
G448S | VRC | ITC, POS | |
M220 | ITC | VRC | POS |
TR34/L98H * | ITC, VRC, POS, ISV | ||
TR46/Y121F/T289A | VRC | ITC, POS | |
TR53 | ITC, VRC | POS |
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Arikan-Akdagli, S.; Ghannoum, M.; Meis, J.F. Antifungal Resistance: Specific Focus on Multidrug Resistance in Candida auris and Secondary Azole Resistance in Aspergillus fumigatus. J. Fungi 2018, 4, 129. https://doi.org/10.3390/jof4040129
Arikan-Akdagli S, Ghannoum M, Meis JF. Antifungal Resistance: Specific Focus on Multidrug Resistance in Candida auris and Secondary Azole Resistance in Aspergillus fumigatus. Journal of Fungi. 2018; 4(4):129. https://doi.org/10.3390/jof4040129
Chicago/Turabian StyleArikan-Akdagli, Sevtap, Mahmoud Ghannoum, and Jacques F. Meis. 2018. "Antifungal Resistance: Specific Focus on Multidrug Resistance in Candida auris and Secondary Azole Resistance in Aspergillus fumigatus" Journal of Fungi 4, no. 4: 129. https://doi.org/10.3390/jof4040129