Recent Advances in the Biosynthesis of Natural Sugar Substitutes in Yeast
Abstract
:1. Introduction
2. Biosynthesis of Oligosaccharides
2.1. 2′-Fucosyllactose (2′-FL)
2.2. Trehalose
3. Biosynthesis of Sugar Alcohols
3.1. Mannitol
3.2. Erythritol
3.3. Threitol
4. Biosynthesis of Glycosides
4.1. Rubusosides
4.2. Glycyrrhizin (GL)
5. Biosynthesis of Rare Monosaccharide
5.1. d-Psicose
5.2. d-Tagatose
6. Conclusions and Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Types | Products | Hosts | Substrate | Fermentation Condition | Titers (g/L) | Yield (g/g) | Productivity (g/L/h) | Reference |
---|---|---|---|---|---|---|---|---|
Oligosaccharides | 2′-Fucosyllactose | S. cerevisiae | Fucose and Lactose | Shake Flask | 0.503 | NA 1 | NA | [22] |
S. cerevisiae | Xylose and Lactose | Fed-Batch Bioreactor | 25.5 | NA | 0.35 | [29] | ||
S. cerevisiae | Glucose and Lactose | 5 L Fed-Batch Bioreactor | 26.63 | NA | 0.28 | [30] | ||
S. cerevisiae | Glucose and Lactose | 5 L Fed-Batch Bioreactor | 32.05 | NA | 0.67 | [31] | ||
Trehalose | Y. lipolytica | Maltose | 3 L Batch Bioreactor | 219 | 0.73 | 4.5 | [34] | |
Sugar alcohols | Mannitol | S. cerevisiae | Glucose | Shake Flask | NA | 0.12 | NA | [35] |
C. magnoliae | Glucose | 2.5 L Fed-Batch Bioreactor | 240 | 0.81 | 4 | [36] | ||
C. parapsilosis | Glucose | 30 L Fed-Batch Bioreactor | 97.1 | 0.34 | 0.81 | [37] | ||
C. magnoliae | Glucose | 10 L Fed-Batch Bioreactor | 223 | 0.89 | 1.72 | [38] | ||
Y. lipolytica | Glucose | 5 L Fed-Batch Bioreactor | 98.2 | 0.33 | 1.1 | [14] | ||
Erythritol | Y. lipolytica | Glycerol | 5 L Fed-batch Bioreactor | 220 | 0.43 | 0.54 | [39] | |
Y. lipolytica | Glucose | Bench-Top Reactors | 148 | NA | NA | [40] | ||
Sugar alcohols | Erythritol | Y. lipolytica | Glucose | 30 m3 Fed-Batch Bioreactor | 196 | 0.65 | 2.51 | [41] |
Y. lipolytica | Crude glycerol | 5 L Fed-Batch Bioreactor | 150 | 0.62 | 1.25 | [15] | ||
P. tsukubaensis | Glucose | 5 L Fed-Batch Bioreactor | 245 | 0.61 | 2.86 | [42] | ||
Moniliella | Glucose and soybean flour | 10 L Fed-batch Bioreactor | 86.6 | 0.47 | 0.40 | [43] | ||
Threitol | Y. lipolytica | Glucose | Shake Flask | 112 | 0.37 | NA | [16] | |
Glycosides | Rubusoside | S. cerevisiae | Glucose | 15 L Fed-Batch Bioreactor | 1.37 | NA | NA | [11] |
Reb A | S. cerevisiae | Glucose | 15 L Fed-Batch Bioreactor | 21.5 mg/L | NA | NA | [11] | |
Reb D | S. cerevisiae | Glucose | 15 L Fed-Batch Bioreactor | 44.2 mg/L | NA | NA | [11] | |
Reb M | S. cerevisiae | Glucose | 15 L Fed-Batch Bioreactor | 67.0 mg/L | NA | NA | [11] | |
GL | S. cerevisiae | Glucose | Shake Flask | 5.98 mg/L | NA | NA | [44] | |
Rare monosaccharide | d-Psicose | K. marxianus | Fructose | Whole-cell Reaction | 190 | 0.253 | 15.83 | [45] |
d-Tagatose | S. cerevisiae | Lactose | 2 L Fed-Batch Bioreactor | 37.69 | 0.526 | 0.1126 | [32] |
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Li, J.; Li, H.; Liu, H.; Luo, Y. Recent Advances in the Biosynthesis of Natural Sugar Substitutes in Yeast. J. Fungi 2023, 9, 907. https://doi.org/10.3390/jof9090907
Li J, Li H, Liu H, Luo Y. Recent Advances in the Biosynthesis of Natural Sugar Substitutes in Yeast. Journal of Fungi. 2023; 9(9):907. https://doi.org/10.3390/jof9090907
Chicago/Turabian StyleLi, Jian, Honghao Li, Huayi Liu, and Yunzi Luo. 2023. "Recent Advances in the Biosynthesis of Natural Sugar Substitutes in Yeast" Journal of Fungi 9, no. 9: 907. https://doi.org/10.3390/jof9090907