Oral Manifestations of Mucormycosis: A Systematic Review
Abstract
:1. Introduction
2. Materials and Methods
2.1. Inclusion Criteria
2.2. Search Strategy
2.2.1. Databases
2.2.2. Search Terms
2.2.3. Study Selection
2.2.4. Data Extraction
2.3. Quality Evaluation
3. Results
3.1. Study Selection and Flow Diagram
3.2. Results of Data Extraction
3.3. Quality Evaluation
3.4. Bibliometric Analysis
4. Discussion
5. Conclusions
Funding
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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INCLUSION CRITERIA | EXCLUSION CRITERIA |
---|---|
Published between 2018 and 2023 | Articles without full text availability |
Articles in English or Spanish | Published in a language other than English or Spanish |
Articles of free full text access or available through the University of Murcia | Articles written exclusively about systemic manifestations of mucormycosis |
With analyzed results obtained | Cases of mucormycosis associated with COVID-19 |
Information about oral manifestations in patients with mucormycosis | |
Followed our search terms |
Database | Search Strategy | Results |
---|---|---|
Medline (PubMed) | 1# “fungal infection” OR mucormycosis | 19,209 |
2# dental OR “oral manifestation*” OR “oral disease” | 664,949 | |
1# AND 2# | 406 | |
Scopus | 1# “fungal infection” OR mucormycosis | 44,271 |
2# dental OR “oral manifestation*” OR “oral disease” | 591,253 | |
1# AND 2# | 411 | |
Web of Science | 1# “fungal infection” OR mucormycosis | 20,253 |
2# dental OR “oral manifestation*” OR “oral disease” | 235,769 | |
1# AND 2# | 136 |
Author, Publication Year | Type of Study | Medical History | Dental History | Most Prevalent Oral Manifestations | Most Frequent Locations |
---|---|---|---|---|---|
Bravo et al. [17], 2018 | Case report | Non-controlled diabetes | Extraction | Periodontal abscess, oral ulcer, and oroantral communication | Alveolar ridge and hard palate |
Gholinejad Ghadi et al. [18], 2018 | Case report | Non-controlled diabetes, neutropenia, and ischemic cardiopathy | Extraction | Swelling, gingival thickening, and necrotic bone exposure | Maxilla, gums, alveolar ridge, and hard palate |
Nezafati et al. [19], 2018 | Cross-sectional study | Diabetes, trauma, MDS, asthma, arthritis rheumatoid, radiotherapy, chemotherapy, and glomerulonephritis | Extractions | Necrosis, oral ulcers, aphthous, and inflammation | Palate, buccal mucosa, and tongue |
Nilesh et al. [20], 2018 | Case report | Healthy | Extractions | Oroantral fistula, necrosis, bone exposure, and halitosis | Maxilla, alveolar bone, and buccal mucosa |
Prabhu et al. [21], 2018 | Case report | Non-controlled diabetes | Extraction | Necrosis | Hard palate, alveolar ridge, and buccal mucosa |
Rai et al. [22], 2018 | Case report | Non-controlled diabetes | Severe periodontitis and extractions | Necrotic oral ulcer, periodontitis, and necrotic bone exposure | Hard palate and alveolar bone |
Venkatesh et al. [23], 2018 | Case report | Healthy | Generalized periodontitis and extractions | Bone exposure and halitosis | Maxilla |
Arani et al. [24], 2019 | Case report | Controlled diabetes | Extraction | Swelling, oroantral communication, and pus discharge | Alveolar ridge and maxillary sinus floor |
Ramadorai et al. [25], 2019 | Prospective analysis (case series) | Non-controlled diabetes and bronchial asthma | None | Swelling, oral ulcer, bone exposure, bone sequestration, and oroantral communication | Palate, cheek, and alveolar bone |
Rani et al. [26], 2019 | Case report | Non-controlled diabetes and controlled hypertension | Extraction | Erosion, necrotic bone exposure, and halitosis | Hard palate and maxillary arch |
Srivastava et al. [27], 2019 | Case report | Trauma to the cheekbone | None | Swelling, pus discharge, abscess, necrotic bone exposure, and mobility | Alveolar ridge and hard palate |
Agarwal et al. [28], 2020 | Case report | Chronic granulomatous disease | Extractions | Mobility, gingival thickening, necrotic bone exposure, pus discharge, and halitosis | Jaw and gums |
Pandilwar et al. [29], 2020 | Case report | Non-controlled diabetes | Extraction | Necrotic bone exposure, necrotic oral ulcer, mobility, pus discharge, and halitosis | Alveolar bone and hard palate |
Panneerselvam et al. [30], 2020 | Case report | Controlled diabetes | Extractions and curettage | Gingival thickening and pus discharge | Alveolar ridge and hard palate |
Rajashri et al. [31], 2020 | Case report | Non-controlled diabetes | Extraction | Necrosis, bone exposure, and halitosis | Maxillary alveolar bone and buccal mucosa |
Ramesh et al. [32], 2020 | Case report | Non-controlled diabetes and dengue | None | Oral ulcer, bone exposure, and halitosis | Hard palate |
Verma et al. [33], 2020 | Case report | Controlled diabetes | None | Necrotic oral ulcer, pus discharge, and halitosis | Hard and soft palate |
Anwar et al. [34], 2021 | Case report | Non-controlled diabetes | None | Necrotic oral ulcer and pus discharge | Hard palate |
Deshpande et al. [12], 2021 | Case report | Non-controlled diabetes and hypertension | Periodontitis, extractions, and endodontics | Gingival thickening, mobility, and periodontal pockets | Alveolar ridge and maxilla |
Beiglboeck et al. [35], 2022 | Case report | Non-controlled diabetes, cirrhosis, kidney disease, and hypertensive heart disease | Endodontics | Inflammation | Maxilla and alveolar ridge |
Country | Number of Patients in Each Study | Gender | Age | |
---|---|---|---|---|
Bravo et al. [17] | Colombia | 1 | Male | 63 |
Gholinejad Ghadi et al. [18] | Iran | 2 | Female Male | 36 53 |
Nezafati et al. [19] | Iran | 40 | Female 19 Male 21 | Average age of 60.6 |
Nilesh et al. [20] | India | 2 | Male Male | 52 37 |
Prabhu et al. [21] | Bahrein | 1 | Male | 70 |
Rai et al. [22] | India | 1 | Male | 57 |
Venkatesh et al. [23] | India | 1 | Male | 32 |
Arani et al. [24] | India | 1 | Male | 48 |
Ramadorai et al. [25] | India | 10 | 3 Female 7 Male | Average age of 49.4 |
Rani et al. [26] | India | 1 | Male | 63 |
Srivastava et al. [27] | India | 1 | Male | 42 |
Agarwal et al. [28] | India | 1 | Male | 37 |
Pandilwar et al. [29] | India | 2 | Male Male | 60 67 |
Panneerselvam et al. [30] | India | 1 | Female | 45 |
Rajashri et al. [31] | India | 1 | Male | 55 |
Ramesh et al. [32] | India | 1 | Male | 23 |
Verma et al. [33] | India | 1 | Female | 58 |
Anwar et al. [34] | Pakistan | 1 | Female | 50 |
Deshpande et al. [12] | India | 1 | Female | 46 |
Beiglboeck et al. [35] | Switzerland | 1 | Male | 74 |
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | Total Score | Risk of Bias * | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nezafati et al. (2018) [19] | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✕ | ✓ | ✕ | ✓ | ✓ | ✓ | ✓ | ✕ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | 17 | Low |
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | Risk of Bias * [%] | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
a | b | c | d | a | b | c | d | a | b | c | d | a | b | c | a | b | c | d | a | b | c | d | |||||||||
Bravo et al. [17] | ✓ | ✓ | ✕ | ✕ | ✕ | ✕ | ✕ | ✓ | ✓ | ✓ | ✕ | ✓ | ✕ | ✓ | ✓ | ✓ | ✕ | ✓ | ✓ | ✕ | ✕ | ✕ | ✕ | ✓ | ✕ | ✓ | ✕ | ✕ | ✕ | ✓ | High [46.67%] |
Gholinejad Ghadi et al. [18] | ✓ | ✓ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✕ | Low [83.33%] |
Nilesh et al. [20] | ✓ | ✕ | ✕ | ✓ | ✓ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✓ | ✓ | ✓ | ✕ | ✕ | ✓ | ✓ | ✕ | ✕ | ✓ | ✓ | ✕ | ✕ | ✓ | Moderate [66.67%] |
Prabhu et al. [21] | ✕ | ✕ | ✓ | ✓ | ✓ | ✕ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✕ | ✓ | ✕ | ✓ | ✓ | ✕ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✕ | Moderate [63.33%] |
Rai et al. [22] | ✓ | ✓ | ✕ | ✓ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✕ | ✓ | ✓ | ✓ | ✕ | ✓ | Low [80%] |
Venkatesh et al. [23] | ✕ | ✕ | ✓ | ✓ | ✕ | ✕ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✕ | ✓ | ✓ | ✕ | ✕ | ✕ | ✕ | ✕ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | Moderate [56.67%] |
Arani et al. [24] | ✓ | ✕ | ✕ | ✓ | ✕ | ✕ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✕ | ✓ | ✕ | ✓ | ✓ | ✕ | ✕ | ✕ | ✕ | ✕ | ✕ | ✓ | ✓ | ✓ | ✕ | ✕ | High [46.67%] |
Ramadorai et al. [25] | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | Low [80%] |
Rani et al. [26] | ✕ | ✓ | ✓ | ✓ | ✕ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✕ | ✓ | ✕ | ✓ | ✕ | ✕ | ✕ | ✕ | ✕ | ✕ | ✓ | ✓ | ✓ | ✕ | ✕ | ✓ | Moderate [53.33%] |
Srivastava et al. [27] | ✕ | ✓ | ✕ | ✓ | ✓ | ✕ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✓ | ✓ | ✕ | ✓ | ✕ | ✓ | ✓ | ✕ | ✕ | ✕ | ✓ | ✓ | ✕ | ✓ | ✓ | ✓ | ✕ | ✓ | Moderate [63.33%] |
Agarwal et al. [28] | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✕ | ✓ | ✓ | ✓ | ✕ | ✓ | Low [90%] |
Pandilwar et al. [29] | ✕ | ✓ | ✕ | ✓ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✕ | ✕ | ✓ | ✓ | ✓ | ✕ | ✕ | ✕ | ✓ | ✕ | ✕ | ✓ | ✓ | ✓ | ✕ | ✓ | Moderate [60%] |
Panneerselvam et al. [30] | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✕ | ✓ | ✓ | ✓ | ✕ | ✓ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | Low [76.67%] |
Rajashri et al. [31] | ✓ | ✕ | ✕ | ✓ | ✕ | ✕ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✕ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✓ | ✕ | ✕ | ✕ | ✓ | ✕ | ✓ | ✕ | ✓ | Moderate [56.67%] |
Ramesh et al. [32] | ✕ | ✓ | ✕ | ✓ | ✕ | ✕ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✓ | ✓ | ✓ | ✕ | ✕ | ✕ | ✓ | ✕ | ✕ | ✓ | ✕ | ✕ | ✕ | ✓ | Moderate [53.33%] |
Verma et al. [33] | ✓ | ✓ | ✕ | ✓ | ✕ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✕ | ✓ | ✓ | ✕ | ✕ | ✕ | ✕ | ✕ | ✕ | ✓ | ✓ | ✕ | ✕ | ✓ | Moderate [56.67%] |
Anwar et al. [34] | ✓ | ✓ | ✕ | ✓ | ✓ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✕ | ✓ | ✓ | ✓ | ✕ | ✓ | ✓ | ✕ | ✕ | ✓ | ✕ | ✓ | ✕ | ✓ | ✕ | ✓ | Moderate [66.67%] |
Deshpande et al. [12] | ✕ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | Low [76.67%] |
Beiglboeck et al. [35] | ✓ | ✕ | ✕ | ✕ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✓ | ✕ | ✓ | ✓ | ✓ | ✓ | ✕ | ✕ | ✓ | ✓ | ✓ | ✓ | ✓ | ✕ | ✕ | Moderate [66.67%] |
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Mora-Martínez, A.; Murcia, L.; Rodríguez-Lozano, F.J. Oral Manifestations of Mucormycosis: A Systematic Review. J. Fungi 2023, 9, 935. https://doi.org/10.3390/jof9090935
Mora-Martínez A, Murcia L, Rodríguez-Lozano FJ. Oral Manifestations of Mucormycosis: A Systematic Review. Journal of Fungi. 2023; 9(9):935. https://doi.org/10.3390/jof9090935
Chicago/Turabian StyleMora-Martínez, Alejandro, Laura Murcia, and Francisco Javier Rodríguez-Lozano. 2023. "Oral Manifestations of Mucormycosis: A Systematic Review" Journal of Fungi 9, no. 9: 935. https://doi.org/10.3390/jof9090935