Short-Term Effects of Two COX-2 Selective Non-Steroidal Anti-Inflammatory Drugs on the Release of Growth Factors and Cytokines from Canine Platelet-Rich Gel Supernatants
Abstract
:1. Introduction
2. Results and Discussion
2.1. Platelet and Leukocyte Concentrations in Whole Blood and Hemocomponents
2.2. Growth Factor Release from Hemocomponents
2.3. Cytokine Release from Hemocomponents
3. Conclusions
4. Materials and Methods
4.1. Animals
4.2. Study Design, Blood Procurement, and Hemocomponent Processing
4.3. Growth Factor and Cytokine Assessment in Hemocomponents
4.4. Statistical Analysis
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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GLMM Number | Fixed Effect | p-Value |
---|---|---|
Intercept | <0.001 | |
Hemocomponent (HC) | <0.001 | |
Treatment | 0.432 | |
1 | Time | 0.552 |
HC × Treatment | 0.961 | |
HC × Time | 0.816 | |
Treatment × Time | 0.826 | |
HC × Treatment × Time | 0.736 | |
Intercept | <0.001 | |
HC | <0.001 | |
Treatment | 0.198 | |
2 | Time | 0.269 |
HC × Treatment | 0.242 | |
HC × Time | 0.156 | |
Treatment × Time | 0.201 | |
HC × Treatment × Time | 0.549 |
GLMM Number | Fixed Effect | p-Value |
---|---|---|
Intercept | <0.001 | |
Hemocomponent (HC) | <0.001 | |
Treatment | 0.891 | |
3 | Time | 0.994 |
HC × Treatment | 0.596 | |
HC × Time | 0.215 | |
Treatment × Time | 0.257 | |
HC × Treatment × Time | 0.083 | |
Intercept | <0.001 | |
HC | <0.001 | |
Treatment | 0.136 | |
4 | Time | 0.917 |
HC × Treatment | 0.546 | |
HC × Time | 0.058 | |
Treatment × Time | 0.350 | |
HC × Treatment × Time | 0.013 |
GLMM Number | Fixed Effect | p-Value |
---|---|---|
Intercept | <0.001 | |
Hemocomponent (HC) | 0.105 | |
Treatment | 0.188 | |
5 | Time | 0.576 |
HC × Treatment | 0.596 | |
HC × Time | 0.019 | |
Treatment × Time | 0.248 | |
HC × Treatment × Time | <0.001 | |
Intercept | <0.001 | |
HC | 0.840 | |
Treatment | 0.144 | |
6 | Time | 0.884 |
HC × Treatment | 0.367 | |
HC × Time | 0.553 | |
Treatment × Time | 0.990 | |
HC × Treatment × Time | <0.001 |
GLMM Number | Fixed Effect | p-Value |
---|---|---|
Intercept | <0.001 | |
Hemocomponent (HC) | 0.001 | |
Treatment | 0.263 | |
7 | Time | <0.001 |
HC × Treatment | 0.046 | |
HC × Time | 0.001 | |
Treatment × Time | 0.066 | |
HC × Treatment × Time | <0.001 |
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Ospina, J.; Carmona, J.U.; López, C. Short-Term Effects of Two COX-2 Selective Non-Steroidal Anti-Inflammatory Drugs on the Release of Growth Factors and Cytokines from Canine Platelet-Rich Gel Supernatants. Gels 2024, 10, 396. https://doi.org/10.3390/gels10060396
Ospina J, Carmona JU, López C. Short-Term Effects of Two COX-2 Selective Non-Steroidal Anti-Inflammatory Drugs on the Release of Growth Factors and Cytokines from Canine Platelet-Rich Gel Supernatants. Gels. 2024; 10(6):396. https://doi.org/10.3390/gels10060396
Chicago/Turabian StyleOspina, Julián, Jorge U. Carmona, and Catalina López. 2024. "Short-Term Effects of Two COX-2 Selective Non-Steroidal Anti-Inflammatory Drugs on the Release of Growth Factors and Cytokines from Canine Platelet-Rich Gel Supernatants" Gels 10, no. 6: 396. https://doi.org/10.3390/gels10060396