Microemulsion-Based Polymer Gels with Ketoprofen and Menthol: Physicochemical Properties and Drug Release Studies
Abstract
:1. Introduction
2. Results and Discussion
2.1. Microemulsion Preparation and Characterization
2.2. Microemulsion-Based Gels: Preparation and Characterization
2.2.1. Rheological Studies
2.2.2. Texture Profile Analysis (TPA)
2.2.3. The Drug Release Studies
3. Conclusions
4. Materials and Methods
4.1. Materials
4.2. Methods
4.2.1. Microemulsion Preparation and Characterization
4.2.2. Microemulsion-Based Gels: Preparation and Characterization
Rheological Studies
- Flow behavior study in controlled shear rate mode (CR; shear rate: 1.0–300.0 s−1, measurement time: 60 s);
- Flow behavior study in controlled shear stress mode (CS; shear stress: 1.0–500.0 Pa, measurement time: 60 s);
- Oscillatory stress sweep (SS; oscillatory stress: 0.1–500.0 Pa; frequency was kept constant at 1.0 Hz);
- Oscillatory frequency sweep (FS; oscillatory frequency: 0.1–10.0 Hz; stress was kept constant at 1.0 Pa, which was based on the results of SS tests).
Texture Profile Analysis (TPA)
Drug Release Studies
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Microemulsions | ||||
---|---|---|---|---|
Component | Placebo | KET | KET-M1 | KET-M5 |
KET [%, w/w] | - | 2.5 | 2.5 | 2.5 |
M [%, w/w] | - | - | 1.0 | 5.0 |
Microemulsion [%, w/w] | 100.0 | 97.5 | 96.5 | 92.5 |
pH | 4.89 ± 0.01 | 4.87 ± 0.01 | 4.82 ± 0.02 | 4.73 ± 0.01 |
Viscosity [mPa s] | 31.29 ± 0.04 | 29.54 ± 0.02 | 29.34 ± 0.08 | 27.91 ± 0.03 |
Parameter | Placebo | KET | KET-M1 | KET-M5 |
---|---|---|---|---|
Peak size [nm] | 3.279 ± 0.169 | 1.877 ± 0.022 | 1.916 ± 0.015 | 2.009 ± 0.029 |
Peak intensity [%] | 73.2 ± 0.6 | 87.5 ± 1.0 | 90.5 ± 1.5 | 100.0 ± 0.0 |
Polydispersity index (PDI) | 0.275 ± 0.001 | 0.266 ± 0.004 | 0.276 ± 0.003 | 0.264 ± 0.004 |
Component | G-Placebo | G-KET | G-KET-M1 | G-KET-M5 |
---|---|---|---|---|
KET [%, w/w] | - | 2.5 | 2.5 | 2.5 |
M [%, w/w] | - | - | 1.0 | 5.0 |
Carbopol® EZ-3 [%, w/w] | 2.0 | 2.0 | 2.0 | 2.0 |
TIPA [%, w/w] | 0.2 | 0.2 | 0.2 | 0.2 |
Microemulsion [%, w/w] | 97.8 | 95.3 | 94.3 | 92.5 |
pH | 5.10 ± 0.02 | 4.81 ± 0.02 | 4.74 ± 0.01 | 4.71 ± 0.01 |
Parameter | G-Placebo | G-KET | G-KET-M1 | G-KET-M5 |
---|---|---|---|---|
[Pa] | 61.57 ± 2.81 | 56.92 ± 1.77 | 32.46 ± 1.81 | 29.64 ± 1.20 |
K [Pa sn] | 21.77 ± 1.40 | 17.81 ± 0.61 | 19.19 ± 3.01 | 17.38 ± 3.18 |
n [-] | 0.60 ± 0.01 | 0.63 ± 0.01 | 0.56 ± 0.02 | 0.61 ± 0.02 |
Yield point (CS) [Pa] | 33.98 ± 1.45 | 29.67 ± 1.46 | 22.19 ± 2.18 | 18.68 ± 0.63 |
Crossover point (SS) [Pa] | 84.00 ± 1.78 | 78.47 ± 2.87 | 60.29 ± 0.50 | 46.31 ± 2.29 |
Parameter | G-Placebo | G-KET | G-KET-M1 | G-KET-M5 |
---|---|---|---|---|
Hardness [mN] | 58.37 ± 3.85 | 54.54 ± 2.76 | 44.25 ± 2.25 | 39.72 ± 1.12 |
Adhesiveness * [mJ] | 568.9 ± 45.1 | 486.8 ± 31.9 | 433.28 ± 43.0 | 433.82 ± 75.0 |
Cohesiveness [-] | 0.94 ± 0.01 | 0.98 ± 0.01 | 0.96 ± 0.01 | 0.97 ± 0.02 |
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Otto, F.; Froelich, A. Microemulsion-Based Polymer Gels with Ketoprofen and Menthol: Physicochemical Properties and Drug Release Studies. Gels 2024, 10, 435. https://doi.org/10.3390/gels10070435
Otto F, Froelich A. Microemulsion-Based Polymer Gels with Ketoprofen and Menthol: Physicochemical Properties and Drug Release Studies. Gels. 2024; 10(7):435. https://doi.org/10.3390/gels10070435
Chicago/Turabian StyleOtto, Filip, and Anna Froelich. 2024. "Microemulsion-Based Polymer Gels with Ketoprofen and Menthol: Physicochemical Properties and Drug Release Studies" Gels 10, no. 7: 435. https://doi.org/10.3390/gels10070435