A Temperature/pH Double-Responsive and Physical Double-Crosslinked Hydrogel Based on PLA and Histidine
Abstract
:1. Introduction
2. Results and Discussion
2.1. HEMA-PLLA30/PDLA30 and Mist Monomers
2.1.1. HEMA-PLLA30/PDLA30 Macromonomers
2.1.2. Mist Monomer
2.2. Synthesis and Characterization of Temperature/pH Double-Responsive and Physical Double-Crosslinked Hydrogel
2.3. Temperature Sensitivity of the Hydrogels
2.4. The pH Sensitivity of the Hydrogel
2.5. Mechanical Properties of the Hydrogel
2.6. Thermogravimetric Analysis (TGA) of Hydrogels
2.7. Environmental Scanning Electron Microscope (ESEM) Analysis of Hydrogels
2.8. Drug Release of the Hydrogel
3. Conclusions
4. Materials and Methods
4.1. Materials
4.2. Synthesis
4.2.1. Synthesis of HEMA-PLLA30 and HEMA-PDLA30 Macromonomers
4.2.2. Synthesis of Mist Monomer
4.2.3. Synthesis of Hydrogen-Bonded Hydrogel
4.2.4. Synthesis of a Coordination-Bond Hydrogel
4.2.5. Synthesis of Double-Crosslinked Hydrogel
4.3. Methods
4.3.1. Spectral Characterization
4.3.2. Thermogravimetric Analysis of the Hydrogels
4.3.3. ESEM Analysis of the Hydrogels
4.3.4. Mechanical Properties Analysis of the Hydrogels
4.3.5. Swelling−Deswelling Behavior of the Hydrogels
4.3.6. Drug Release of the Hydrogels
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Sample | (HEMA-PLLA30):(HEMA-PDLA30) n:n | MEO2MA/OEGMA n:n | Mist (mmol) | cZn(Ⅱ) (mol/L) |
---|---|---|---|---|
gel 1 | 1:1 | 90:10 | 0 | 0 |
gel 2 | 1:1 | 90:10 | 1.79 | 0.1 |
gel 3 | 0:0 | 90:10 | 1.79 | 0.1 |
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Wu, Q.; Fu, Y.; Yang, W.; Liu, S. A Temperature/pH Double-Responsive and Physical Double-Crosslinked Hydrogel Based on PLA and Histidine. Gels 2022, 8, 570. https://doi.org/10.3390/gels8090570
Wu Q, Fu Y, Yang W, Liu S. A Temperature/pH Double-Responsive and Physical Double-Crosslinked Hydrogel Based on PLA and Histidine. Gels. 2022; 8(9):570. https://doi.org/10.3390/gels8090570
Chicago/Turabian StyleWu, Qingrong, Yu Fu, Wanying Yang, and Shouxin Liu. 2022. "A Temperature/pH Double-Responsive and Physical Double-Crosslinked Hydrogel Based on PLA and Histidine" Gels 8, no. 9: 570. https://doi.org/10.3390/gels8090570