Injectable Methacrylated Gelatin Hydrogel for Safe Sodium Hypochlorite Delivery in Endodontics
Abstract
:1. Introduction
2. Results and Discussion
2.1. Chemo-Morphological Characterization
2.2. Mechanical Characterization
2.3. Swelling and Enzymatic Degradation
2.4. Cytocompatibility
2.5. Antibacterial Properties
2.6. Antibiofilm Properties
2.7. Chlorine Test
2.8. In Vivo Biocompatibility and Biodegradation
3. Conclusions
4. Materials and Methods
4.1. Chemical and Materials
4.2. NaOCl-HNT Loading
4.3. Gelatin Methacryloyl (GelMA)
4.4. Preparation of NaOCl-HNT-GelMA Hydrogels
4.5. Chemo-Morphological Characterization
4.6. Mechanical Characterization
4.7. Swelling and Enzymatic Degradation
4.8. Cytotoxicity
4.9. Antibacterial Properties
4.10. Antibiofilm Properties
4.11. Chlorine Test
4.12. In Vivo Biocompatibility and Biodegradation
4.13. Statistical Analysis
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Dal-Fabbro, R.; Huang, Y.-C.; Toledo, P.T.A.; Capalbo, L.C.; Coleman, R.M.; Sasaki, H.; Fenno, J.C.; Bottino, M.C. Injectable Methacrylated Gelatin Hydrogel for Safe Sodium Hypochlorite Delivery in Endodontics. Gels 2023, 9, 897. https://doi.org/10.3390/gels9110897
Dal-Fabbro R, Huang Y-C, Toledo PTA, Capalbo LC, Coleman RM, Sasaki H, Fenno JC, Bottino MC. Injectable Methacrylated Gelatin Hydrogel for Safe Sodium Hypochlorite Delivery in Endodontics. Gels. 2023; 9(11):897. https://doi.org/10.3390/gels9110897
Chicago/Turabian StyleDal-Fabbro, Renan, Yu-Chi Huang, Priscila T. A. Toledo, Leticia C. Capalbo, Rhima M. Coleman, Hajime Sasaki, J. Christopher Fenno, and Marco C. Bottino. 2023. "Injectable Methacrylated Gelatin Hydrogel for Safe Sodium Hypochlorite Delivery in Endodontics" Gels 9, no. 11: 897. https://doi.org/10.3390/gels9110897