Designing Antimicrobial Hydrogels for Local Application

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Chemistry and Physics".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 1919

Special Issue Editors

School of Pharmacy, Changzhou University, Changzhou 213164, China
Interests: nanomaterials; polymers; antibacterial materials; hydrogels
Special Issues, Collections and Topics in MDPI journals
School of Pharmacy, Changzhou University, Changzhou, 213164, China
Interests: biomaterials, biosensor chip, nanomedicine
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
School of Pharmacy, Changzhou University, Changzhou 213164, China
Interests: gene delivery, nanomedicine, pharmacokinetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The rapid emergence of drug-resistant microbes has become a worldwide health issue, especially those associated with impaired wound healing and biomedical implant failure. To achieve efficient antimicrobial therapy, the local application of biomaterials with antibacterial activity might be a solution. Hydrogel, a kind of polymer-based material capable of holding large amounts of water in its three-dimensional networks, has been shown in local applications and combats many diseases. Antimicrobial hydrogels as a novel weapon in the arsenal of antibacterial materials have shown huge potential against multidrug-resistant infections. Processes in synthetic chemistry have made it possible to tailor the molecular structure, the functionality to impart broad-spectrum antimicrobial activity, and adjustable mechanical properties. However, there remain challenges that need to be solved in this field which requires further attention from the scientific community.

Therefore, the goal of this Special Issue is to introduce recent advances in antimicrobial hydrogels. We aim to offer readers insights into frontier developments in this field by presenting select high-quality studies. This Special Issue will feature recent advances in the design, evaluation, and application of antimicrobial hydrogels. Manuscripts that present the synthesis of novel antibacterial hydrogels, the application of multi-response antibacterial hydrogels, joint application of antibacterial hydrogels with other antibacterial materials, are especially welcome.

Dr. Lin Qiu
Dr. Songwei Lv
Dr. Pengfei Cui
Guest Editors

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Keywords

  • hydrogel
  • antibacterial
  • local application
  • tailor chemical structure
  • multi-response
  • infection

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Published Papers (1 paper)

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Research

16 pages, 9564 KiB  
Article
Injectable Methacrylated Gelatin Hydrogel for Safe Sodium Hypochlorite Delivery in Endodontics
by Renan Dal-Fabbro, Yu-Chi Huang, Priscila T. A. Toledo, Leticia C. Capalbo, Rhima M. Coleman, Hajime Sasaki, J. Christopher Fenno and Marco C. Bottino
Gels 2023, 9(11), 897; https://doi.org/10.3390/gels9110897 - 13 Nov 2023
Cited by 3 | Viewed by 1667
Abstract
Keeping sodium hypochlorite (NaOCl) within the root canal is challenging in regenerative endodontics. In this study, we developed a drug delivery system using a gelatin methacryloyl (GelMA) hydrogel incorporated with aluminosilicate clay nanotubes (HNTs) loaded with NaOCl. Pure GelMA, pure HNTs, and NaOCl-loaded [...] Read more.
Keeping sodium hypochlorite (NaOCl) within the root canal is challenging in regenerative endodontics. In this study, we developed a drug delivery system using a gelatin methacryloyl (GelMA) hydrogel incorporated with aluminosilicate clay nanotubes (HNTs) loaded with NaOCl. Pure GelMA, pure HNTs, and NaOCl-loaded HNTs carrying varying concentrations were assessed for chemo-mechanical properties, degradability, swelling capacity, cytocompatibility, antimicrobial and antibiofilm activities, and in vivo for inflammatory response and degradation. SEM images revealed consistent pore sizes of 70–80 µm for all samples, irrespective of the HNT and NaOCl concentration, while HNT-loaded hydrogels exhibited rougher surfaces. The hydrogel’s compressive modulus remained between 100 and 200 kPa, with no significant variations. All hydrogels demonstrated a 6–7-fold mass increase and complete degradation by the seventh day. Despite an initial decrease in cell viability, all groups recovered to 65–80% compared to the control. Regarding antibacterial and antibiofilm properties, 12.5 HNT(Double) showed the highest inhibition zone on agar plates and the most significant reduction in biofilm compared to other groups. In vivo, the 12.5 HNT(Double) group displayed partial degradation after 21 days, with mild localized inflammatory responses but no tissue necrosis. In conclusion, the HNT-NaOCl-loaded GelMA hydrogel retains the disinfectant properties, providing a safer option for endodontic procedures without harmful potential. Full article
(This article belongs to the Special Issue Designing Antimicrobial Hydrogels for Local Application)
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