L-Lysine-Modified pNIPAm-co-GMA Copolymer Hydrogel for pH- and Temperature-Responsive Drug Delivery and Fluorescence Imaging Applications
Abstract
:1. Introduction
2. Results and Discussion
2.1. Characterization of pNIPAAm-co-GMA and pNIPAAm-co-GMA-Lys HG Samples
2.2. Stimuli-Responsive Drug Delivery Behavior of the pNIPAAm-co-GMA-Lys/Cur HG System
2.3. Cell Viability Study
2.4. Fluorescence Image Analysis
3. Conclusions
4. Chemicals
4.1. Preparation of pNIPAAm-co-GMA-Lys HG System
4.2. Characterization
4.3. Turbidity Measurement
4.4. Drug Loading and Release Behavior of the pNIPAAm-co-GMA-Lys HG
4.5. Biocompatibility Study
4.6. Fluorescence Imaging Study
4.7. Statistical Analysis
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Sample | LCST (°C) | Drug Release (%) | ||
---|---|---|---|---|
25 °C | 37 °C | 45 °C | ||
pNIPAAm-co-GMA-Lys/Cur HG | ~38–40 | 17 | 22 | 37 |
pH | Drug Release (%) |
---|---|
7.4 | 18 |
6.2 | 68 |
4.0 | 90 |
45 °C/7.4 | 22 |
45 °C/6.2 | 83 |
45 °C/4.0 | 100 |
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Santhamoorthy, M.; Vanaraj, R.; Thirupathi, K.; Ulagesan, S.; Nam, T.-J.; Phan, T.T.V.; Kim, S.-C. L-Lysine-Modified pNIPAm-co-GMA Copolymer Hydrogel for pH- and Temperature-Responsive Drug Delivery and Fluorescence Imaging Applications. Gels 2023, 9, 363. https://doi.org/10.3390/gels9050363
Santhamoorthy M, Vanaraj R, Thirupathi K, Ulagesan S, Nam T-J, Phan TTV, Kim S-C. L-Lysine-Modified pNIPAm-co-GMA Copolymer Hydrogel for pH- and Temperature-Responsive Drug Delivery and Fluorescence Imaging Applications. Gels. 2023; 9(5):363. https://doi.org/10.3390/gels9050363
Chicago/Turabian StyleSanthamoorthy, Madhappan, Ramkumar Vanaraj, Kokila Thirupathi, Selvakumari Ulagesan, Taek-Jeong Nam, Thi Tuong Vy Phan, and Seong-Cheol Kim. 2023. "L-Lysine-Modified pNIPAm-co-GMA Copolymer Hydrogel for pH- and Temperature-Responsive Drug Delivery and Fluorescence Imaging Applications" Gels 9, no. 5: 363. https://doi.org/10.3390/gels9050363