Modeling and Simulation of Batch Sugarcane Alcoholic Fermentation Using the Metabolic Model

Round 1

Reviewer 1 Report

The manuscript includes most of my remarks, several aspects have been clarified. 
I appreciated the author's effort to document the models in the literature, the clarifications concerning the choice of initial conditions. 
My final remarks concern the name of Section 2, which does not seem appropriate to me, as it does not only present the experiments, but especially the model with the assumptions and the mathematical formulation.
Despite this aspect which could easily be taken into account, I recommend the acceptance of the article for publication.
Minor remark: line 35 batch-fed replace by fed-batch or sequential batch depending on what the author means 

Author Response

Reviewer #1

 

 

• The manuscript includes most of my remarks, several aspects have been clarified. I appreciated the author's effort to document the models in the literature, the clarifications concerning the choice of initial conditions.

 

Answer:

Thank you for your support, your suggestions were of great relevance to our work and with them we could improve it even more.

 

• My final remarks concern the name of Section 2, which does not seem appropriate to me, as it does not only present the experiments, but especially the model with the assumptions and the mathematical formulation.

 

Answer:

Thanks for the suggestion. We have renamed the section to “Methods and Experimental Procedures” to refer to the study of the models and methods involved.

 

• Despite this aspect which could easily be taken into account, I recommend the acceptance of the article for publication.

 

 

Answer:

We are sincerely grateful for the significance given to our work.

 

 

• Minor remark: line 35 batch-fed replace by fed-batch or sequential batch depending on what the author means

 

Answer:

Thanks for the suggestion. We have replaced the term “batch-fed” for “sequential batch”.

 

 

Dear Reviewer:

 

Thank you for reviewing our manuscript and for your valuable comments and suggestions to improve the manuscript quality. Based on your suggestions, the manuscript has been carefully revised. We are looking forward to receiving your appreciation.

 

With best wishes,

Cid Marcos G Andrade.

 

 

Author Response File: Author Response.docx

Reviewer 2 Report

The issues are fixed

Author Response

Reviewer #2

 

The issues are fixed.

 

Dear Reviewer:

 

Thank you for reviewing our manuscript and for your valuable comments and suggestions to improve the manuscript quality. Based on your suggestions, the manuscript has been carefully revised.

 

With best wishes,

Cid Marcos G Andrade.

 

Author Response File: Author Response.docx