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Peer-Review Record

Enhancing the Productivity and Stability of Superoxide Dismutase from Saccharomyces cerevisiae TBRC657 and Its Application as a Free Radical Scavenger

Fermentation 2022, 8(4), 169; https://doi.org/10.3390/fermentation8040169
by Phitsanu Pinmanee 1,2, Kamonwan Sompinit 2, Jantima Arnthong 2, Surisa Suwannarangsee 2, Angkana Jantimaporn 3, Mattaka Khongkow 3, Thidarat Nimchua 2 and Prakit Sukyai 1,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Fermentation 2022, 8(4), 169; https://doi.org/10.3390/fermentation8040169
Submission received: 23 March 2022 / Revised: 3 April 2022 / Accepted: 4 April 2022 / Published: 6 April 2022
(This article belongs to the Topic Bioreactors: Control, Optimization and Applications)

Round 1

Reviewer 1 Report

The authors show data on the different steps for production, isolation and stabilization of SOD from a specific strain of S. cerevisiae. The manuscript is well written, although it could be strongly reduced without impacting on the reader comprehension of the main message.

major concern:

-  the data on the protective effect of SOD on cell viability of fibroblast, or its putative toxic effect, lacks statistical analysis for a real understanding of the differences observed.  Moreover, the data on the protective effect of SOD on the oxidative induced stress by hydrogen peroxide on fibroblasts is over interpreted. I am not convinced that the authors have data to say that “SOD had the potential to eliminate the ROS produced inside the cell…. “(pag 475 line 464-466). In my opinion this data should be left out of the manuscript as its interpretation is questionable, and it does not add any other layer of complexity in the data presented.

- in the tables it is missing the meaning of the small letters (a, b, ….) probably are related with statistical analysis.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report


Comments for author File: Comments.pdf

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

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