Connectivity Reveals the Relationships between Human Brain Areas Associated with High-Level Linguistic Processing and Macaque Brain Areas

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

The study compare human and macaque brain regions in advanced language processing, but there are concerns that need to be addressed：

1. The paper has quite some redundancy with prior literature.

2.The English expression has numerous issues. Professional polishing is recommended.

3. The manuscript doesn't clearly state its contribution.

4.The paper lack critical evaluation of potential confounds. High structural connectivity between specific human and macaque brain regions may be influenced by factors beyond language processing.

5. The selection of experimental subjects is not particularly appropriate: humans are young to middle-aged, while the macaques are elderly.

6. Some important DWI imaging parameters are missing, for instance, the b-value.

7.The processing pipeline of FSL is optimized for human brain anatomy. Direct application of FSL to macaques can introduce various biases.

8. Similarly, in tractography, the authors need to consider modifying the processing pipeline to suit macaque.

9. For the processing of macaque images, the authors should provide assessment results to demonstrate the reliability of the processing.

 

Comments on the Quality of English Language

N/A

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

This is an informative article comparing connectivity between macques and human  language-related brain regions.  Here are two suggestions to help improve the manuscript:

1)  Add show examples of connectivity finger prints similar to presented in this manuscript for both macaque and human brain.

https://www.sciencedirect.com/science/article/pii/S1364661318302092

2)  Add an example FA images for both macaque and human brain so the readers can see the quality of the DTI image data

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

Comments and Suggestions for Authors

The English language in the article has still some issues. The author may need to consider utilizing a professional editing service. Additionally, the author's responses to several issues are unsatisfactory. For macaques, 15 years and beyond is considered old age, not adulthood as the author claims. Furthermore, I am unclear about the reference to 'b5' in the author's response, but 'b0' is one of the most important parameters in DTI imaging.

 

Comments on the Quality of English Language

N/A

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Round 3

Reviewer 1 Report

Comments and Suggestions for Authors

All revisions have been appropriately addressed and refined. I recommend proceeding with publication.

Comments on the Quality of English Language

N/A