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Tomography
Volume 2
Issue 4
10.18383/j.tom.2016.00247
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Tomography is published by MDPI from Volume 7 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Grapho, LLC.
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Article

Effect of MR Imaging Contrast Thresholds on Prediction of Neoadjuvant Chemotherapy Response in Breast Cancer Subtypes: A Subgroup Analysis of the ACRIN 6657/I-SPY 1 TRIAL

by
Wen Li
1,*,
Vignesh Arasu
1,
David C. Newitt
1,
Ella F. Jones
1,
Lisa Wilmes
1,
Jessica Gibbs
1,
John Kornak
2,
Bonnie N. Joe
1,
Laura J. Esserman
3 and
Nola M. Hylton
1 ACRIN 6657 Trial Team and I-SPY Investigators Network
1
Departments of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
2
Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA
3
Surgery, University of California San Francisco, San Francisco, CA, USA
*
Author to whom correspondence should be addressed.
Tomography 2016, 2(4), 378-387; https://doi.org/10.18383/j.tom.2016.00247
Submission received: 7 September 2016 / Revised: 4 October 2016 / Accepted: 3 November 2016 / Published: 1 December 2016
Versions Notes

Abstract

Functional tumor volume (FTV) measurements by dynamic contrast-enhanced magnetic resonance imaging can predict treatment outcomes for women receiving neoadjuvant chemotherapy for breast cancer. Here, we explore whether the contrast thresholds used to define FTV could be adjusted by breast cancer subtype to improve predictive performance. Absolute FTV and percent change in FTV (ΔFTV) at sequential time-points during treatment were calculated and investigated as predictors of pathologic complete response at surgery. Early percent enhancement threshold (PEt) and signal enhancement ratio threshold (SERt) were varied. The predictive performance of resulting FTV predictors was evaluated using the area under the receiver operating characteristic curve. A total number of 116 patients were studied both as a full cohort and in the following groups defined by hormone receptor (HR) and HER2 receptor subtype: 45 HR+/HER2−, 39 HER2+, and 30 triple negatives. High AUCs were found at different ranges of PEt and SERt levels in different subtypes. Findings from this study suggest that the predictive performance to treatment response by MRI varies by contrast thresholds, and that pathologic complete response prediction may be improved through subtype-specific contrast enhancement thresholds. A validation study is underway with a larger patient population.
Keywords: MRI; breast cancer; neoadjuvant; contrast enhancement MRI; breast cancer; neoadjuvant; contrast enhancement

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MDPI and ACS Style

Li, W.; Arasu, V.; Newitt, D.C.; Jones, E.F.; Wilmes, L.; Gibbs, J.; Kornak, J.; Joe, B.N.; Esserman, L.J.; Hylton, N.M., ACRIN 6657 Trial Team and I-SPY Investigators Network. Effect of MR Imaging Contrast Thresholds on Prediction of Neoadjuvant Chemotherapy Response in Breast Cancer Subtypes: A Subgroup Analysis of the ACRIN 6657/I-SPY 1 TRIAL. Tomography 2016, 2, 378-387. https://doi.org/10.18383/j.tom.2016.00247

AMA Style

Li W, Arasu V, Newitt DC, Jones EF, Wilmes L, Gibbs J, Kornak J, Joe BN, Esserman LJ, Hylton NM ACRIN 6657 Trial Team and I-SPY Investigators Network. Effect of MR Imaging Contrast Thresholds on Prediction of Neoadjuvant Chemotherapy Response in Breast Cancer Subtypes: A Subgroup Analysis of the ACRIN 6657/I-SPY 1 TRIAL. Tomography. 2016; 2(4):378-387. https://doi.org/10.18383/j.tom.2016.00247

Chicago/Turabian Style

Li, Wen, Vignesh Arasu, David C. Newitt, Ella F. Jones, Lisa Wilmes, Jessica Gibbs, John Kornak, Bonnie N. Joe, Laura J. Esserman, and Nola M. Hylton ACRIN 6657 Trial Team and I-SPY Investigators Network. 2016. "Effect of MR Imaging Contrast Thresholds on Prediction of Neoadjuvant Chemotherapy Response in Breast Cancer Subtypes: A Subgroup Analysis of the ACRIN 6657/I-SPY 1 TRIAL" Tomography 2, no. 4: 378-387. https://doi.org/10.18383/j.tom.2016.00247

APA Style

Li, W., Arasu, V., Newitt, D. C., Jones, E. F., Wilmes, L., Gibbs, J., Kornak, J., Joe, B. N., Esserman, L. J., & Hylton, N. M., ACRIN 6657 Trial Team and I-SPY Investigators Network. (2016). Effect of MR Imaging Contrast Thresholds on Prediction of Neoadjuvant Chemotherapy Response in Breast Cancer Subtypes: A Subgroup Analysis of the ACRIN 6657/I-SPY 1 TRIAL. Tomography, 2(4), 378-387. https://doi.org/10.18383/j.tom.2016.00247

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