The Efficacy of CT Temporal Subtraction Images for Fibrodysplasia Ossificans Progressiva

Round 1

Reviewer 1 Report

Title: good but I think better if written as (The efficacy of CT Temporal Subtraction images for Fibrodysplasia Ossificans Progressiva)

Use word interpreter if you mean reader interpreter.

If any future or extra research is required, please include it after the conclusion in the abstract section.

Line of introduction Line 46: 'CT is most commonly used for patient monitoring.' I believe the following word (CT is) adequately expresses the meaning.

The significance of the study, as well as its goal, are well expressed.

Materials and Methods: inclusion criteria, study period, analysis method, and evaluation technique are all clear to me.

Results: This section is well illustrated with tables and figures.

Discussion: You should cite more references to back up your findings.

Try to cite some references from this journal (tomography if available and appropriate for the citation position).

Conclusion: expand this section according to your efforts throughout this manuscript. 

Author Response

Dear Reviewers,

Thank you for your thoughtful review of our manuscript. We have carefully considered your comments and suggestions, and we have made the following revisions:

Title: good but I think better if written as (The efficacy of CT Temporal Subtraction images for Fibrodysplasia Ossificans Progressiva)

→Thank you for your kind suggestion. We have changed the title as you suggested to "The efficacy of CT Temporal Subtraction images for Fibrodysplasia Ossificans Progressiva."

Use word interpreter if you mean reader interpreter.

→Thank you for your suggestion. We have revised the manuscript to use the word "interpreter" instead of "reader" to make it more clear.

If any future or extra research is required, please include it after the conclusion in the abstract section.

→Thank you for your suggestion. We have added a statement about future research in the abstract section.

Line of introduction Line 46: 'CT is most commonly used for patient monitoring.' I believe the following word (CT is) adequately expresses the meaning.

→Thank you for your kind suggestion. Accordingly, the “readers” have been changed into “interpreters”.

Discussion: You should cite more references to back up your findings.

Try to cite some references from this journal (tomography if available and appropriate for the citation position).

→Thank you for your suggestion. We have added more references to support our findings throughout the discussion and cited some from the journal Tomography, where appropriate.

Conclusion: expand this section according to your efforts throughout this manuscript.

→ Thank you for your suggestion. We have expanded the conclusion section to better reflect our findings throughout the manuscript.

Reviewer 2 Report

Dear Editor and authors,

I have carefully read the manuscipt.

In my opinion, the shortcoming of this manuscript is the rarity of FOP; thus, the data used in the study analysis is limited (only three cases). In addition, interest in this topic is limited. 

The authors suggest a new field of applicability (although concerning a rare genetic disorder) for this post-processing CT data technique of temporal subtraction (TS). This could lead to considering other than heterotopic ossification-related (inherited or not), not yet published uses of the TS method.

This last comment could be added in the discussion section. Regardless of the improved TS sensitivity in the FOP disease-field CT evaluation, the TS method could be kept in mind to support CT visual evaluation and interpretation in other disease fields.

Yours sincerely,

Author Response

Dear Reviewers,

Thank you for your thoughtful review of our manuscript. We agree with your suggestion that the potential for other uses of the TS method could be added to the discussion section. We believe that the TS method has the potential to be applied in other areas beyond FOP, including the detection of other systemic bone diseases such as osteomalacia, ankylosing spondylitis, or diffuse idiopathic skeletal hyperostosis. The improved sensitivity of the TS method may lead to improved detection and monitoring of these diseases. We have added this suggestion to the discussion section and included relevant references to support this idea. 

Thank you for your valuable comments and suggestions, which have helped us improve the manuscript.