Non-Invasive Mapping of Cerebral Autoregulation Using Near-Infrared Spectroscopy: A Study Protocol
Abstract
:1. Introduction
2. Experimental Design
2.1. Objective 1
2.2. Objective 2
2.3. Recruitment of Human Participants
2.4. Physiologic Monitoring Systems
2.5. High-Frequency Data Acquisition
2.6. Physiologic Data Processing
2.7. General Statistical Methodologies
2.8. Pitfall Mitigation
3. Procedure
3.1. Objective 1 Testing Protocol
3.1.1. Transient Hyperemic Response Test (6 min)
3.1.2. Orthostatic Challenge Test (35 min)
3.1.3. Vascular Chemo-Reactivity Test (12 min)
3.1.4. Neurovascular Coupling Test (20 min)
3.2. Objective 2 Testing Protocol
3.2.1. Static Test (30 min)
3.2.2. Orthostatic Challenge Test (8 min)
3.2.3. Vascular Chemo-Reactivity Test (9 min)
3.2.4. Neurovascular Coupling Test (10 min)
4. Expected Results
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Abbreviation | CVR Metric | Correlation Between |
---|---|---|
HbOx | Oxyhemoglobin Index | HbO and ABP |
HHbx | Deoxyhemoglobin Index | HHb and ABP |
tHbx | Total Hemoglobin Index | tHb and ABP |
HbDiffx | Hemoglobin Difference Index | HbDiff and ABP |
Block | Test | Method | Perturbation Time | Interval Time | Repetition | Total Time |
---|---|---|---|---|---|---|
Rest Phase | ||||||
1 | Transient hyperemic response | Carotid compression | 5 s | 1 min | 5 times | ~6 min |
Rest Phase | ||||||
2 | Orthostatic challenge | Lying-to-sit and sit-to-stand | Instantaneous | 3 min | 5 times | ~35 min |
Rest Phase | ||||||
3 | Vascular chemo-reactivity | Breathing Exercises (fast/slow) | 2.5 and 1.5 min | 2.5 and 1.5 min | 2 times | ~12 min |
Rest Phase | ||||||
4 | Neurovascular coupling | ANAM GNS Clinical Toolkit | N/A | N/A | N/A | ~20 min |
Rest Phase |
Block | Test | Method | Perturbation Time | Interval Time | Repetition | Total Time |
---|---|---|---|---|---|---|
1 | Static | Normal sitting position | N/A | N/A | N/A | ~30 min |
2 | Orthostatic challenge | Lying-to-sit and sit-to-stand | Instantaneous | 2 min | 2 times | ~8 min |
Rest Phase | ||||||
3 | Vascular chemo-reactivity | Breathing Exercises (fast/slow) | 2 and 1 min | 2 and 1 min | 2 times | ~9 min |
Rest Phase | ||||||
4 | Neurovascular coupling | ANAM Stroop Test | N/A | N/A | N/A | ~10 min |
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Sainbhi, A.S.; Vakitbilir, N.; Gomez, A.; Stein, K.Y.; Froese, L.; Zeiler, F.A. Non-Invasive Mapping of Cerebral Autoregulation Using Near-Infrared Spectroscopy: A Study Protocol. Methods Protoc. 2023, 6, 58. https://doi.org/10.3390/mps6030058
Sainbhi AS, Vakitbilir N, Gomez A, Stein KY, Froese L, Zeiler FA. Non-Invasive Mapping of Cerebral Autoregulation Using Near-Infrared Spectroscopy: A Study Protocol. Methods and Protocols. 2023; 6(3):58. https://doi.org/10.3390/mps6030058
Chicago/Turabian StyleSainbhi, Amanjyot Singh, Nuray Vakitbilir, Alwyn Gomez, Kevin Y. Stein, Logan Froese, and Frederick A. Zeiler. 2023. "Non-Invasive Mapping of Cerebral Autoregulation Using Near-Infrared Spectroscopy: A Study Protocol" Methods and Protocols 6, no. 3: 58. https://doi.org/10.3390/mps6030058