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Volume 6
Issue 2
10.3390/vision6020026
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Article
Peer-Review Record

Radial Peripapillary Capillary Plexus Perfusion and Endothelial Dysfunction in Early Post-SARS-CoV-2 Infection

Vision 2022, 6(2), 26; https://doi.org/10.3390/vision6020026
by Maria Cristina Savastano 1,2, Luca Santoro 3, Emanuele Crincoli 1,2, Claudia Fossataro 1,2,*, Gloria Gambini 1,2, Alfonso Savastano 1,2, Umberto De Vico 1,2, Angelo Santoliquido 4, Antonio Nesci 4, Francesco Landi 5, Stanislao Rizzo 1,2,6 and on behalf of Gemelli against COVID-19 Post-Acute Care Study Group †
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Vision 2022, 6(2), 26; https://doi.org/10.3390/vision6020026
Submission received: 28 March 2022 / Revised: 27 April 2022 / Accepted: 2 May 2022 / Published: 16 May 2022

Round 1

Reviewer 1 Report

This study investigated the association between endothelial function and retinal vascular parameters in early post COVID-19 patients. A total of 82 post COVID-19 patients were included in the study. Flow-mediated dilation (FMD), optical coherence tomography (OCT), and OCT angiography were performed. The authors found that the peripapillary capillary plexus – flow index (RPCP-FI) was correlated with FMD values. The authors conclude that early post COVD-19 patients showed a higher prevalence of FMD impairment compared to the general population.

 

  1. Please present the characteristic images of OCT and OCTA to describe different parameters measured on these images.
  2. Do you have any data on the condition of the carotid artery in these patients? Any carotid plaques or stenosis?

Author Response

Please see the attachment

Author Response File: Author Response.docx

Reviewer 2 Report

This is an interesting study showing  the association between flow-mediated dilation (FMD) impairment and retinal vascular parameters in early post COVID-19 patients.  What device (company etc. ) has been used for FMD measurements? What was the basis for exclusion criteria? Why previous myocardial infarction, previous ischemic stroke, peripheral arterial occlusive disease were exclusion criteria and diabetes and arterial hypertension were not taken as exclusion criteria? Was any control group included? The studied group was quite heterogenous, it may alter the results.

In the abstract it is not mentioned about OCT-A parameters (especially subfoveal choroidal thickness) in the results and conclusion sections. In the discussion section studies analysing OCT-A in post COVID patients should be cited.

Author Response

Please see the attachment

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

All my concerns have been well addressed. Thank you!

Reviewer 2 Report

No additional comments

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