Dopamine (DA) is an important catecholamine neurotransmitter that plays a relevant role in the human body’s function. Disorders in DA concentrations are related to several neurological diseases such as Parkinson, Alzheimer and schizophrenia. Common physiologic interferences of this neurotransmitter via voltammetric determination are, among others, uric acid (UA), ascorbic acid (AA) and serotonin (5-HT).
The use of graphene derivatives in sensors field offer possibilities such as low-cost devices, easy monitoring, miniaturization and biocompatibility. Moreover, electrochemical detection techniques coupled with nanomaterials lead to the enhancement of sensor sensitivity and selectivity due to their chemical and electrochemical properties.
The goal of the study is to determine DA in biological systems using a laboratory made electrode, built employing a composite mixture formed by graphite and epoxy resin as transducer material. The surface of this transducer is coated via drop casting with electroreduced graphene oxide (ERGO) to obtain the finally used sensor with improved electrochemical response. Multicomponent determination is accomplished employing the complete voltammogram signal, after its processing using artificial neural networks (ANNs). The followed approach allowed the resolution of signal overlapping and the quantification of the individual species sought.
Conflicts of Interest
The authors declare no conflict of interest.
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