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Extended Abstract

Podoplanin Expression and Its Correlation with Perineural Invasion in Oral Squamous Cell Carcinoma †

by
Roberto Rossi
1,*,
Achille Tarsitano
2,
Sofia Asioli
3,
Alice Piastra
1,
Andrea Gabusi
1,
Luca Morandi
3,
Laura Luccarini
1,
Laura Felicetti
1 and
Davide B. Gissi
1
1
Department of Biomedical and Neuromotor Sciences, Section of Oral Sciences, University of Bologna, 40159 Bologna, Italy
2
Department of Biomedical and Neuromotor Sciences, Section of Maxillo-Facial Surgery at Policlinico S. Orsola-Malpighi, University of Bologna, 40138 Bologna, Italy
3
Department of Biomedical and Neuromotor Sciences, Section of Anatomic Pathology at Bellaria Hospital, University of Bologna, 40139 Bologna, Italy
*
Author to whom correspondence should be addressed.
†
Presented at the XV National and III International Congress of the Italian Society of Oral Pathology and Medicine (SIPMO), Bari, Italy, 17–19 October 2019.
Proceedings 2019, 35(1), 34; https://doi.org/10.3390/proceedings2019035034
Published: 11 December 2019
(This article belongs to the Proceedings of The XV National and III International Congress of the Italian Society of Oral Pathology and Medicine)
Versions Notes

1. Introduction

Perineural invasion (PNI) represents cancer propension to spread through neuronal pathways and hinders the ability to establish a surgical local control of Oral Squamous Cell Carcinoma (OSCC). Histologic evidence of PNI is a recognized poor prognostic factor related with an high risk of loco-regional recurrence and/or presence of an occult lymphnode metastasis.
Unfortunately, PNI can be evaluated only in surgical specimens of OSCC and not in preoperative incisional biopsies, rendering timely therapeutic planning impossible.
Identification of a pre-operative reliable molecular marker related with presence of PNI may represent an attractive strategy. In this sense, recent studies showed that podoplanin is overexpressed in aggressive tumors and is associated with cervical lymphatic dissemination and poor survival in OSCC [1].
The aim of this study is to evaluate the relationship between Podoplanin altered expression in pre-operative incisional biopsy and presence of PNI in surgical OSCC sample and their prognostic role.

2. Materials and Methods

The cohort of this study consisted of 85 consecutive OSCC patients (average follow-up: 21.46 months). In all cases a pre-operative incisional biopsy for histological assessment and immunohistochemical analysis of Popoplanin was performed. PNI evidence was histologically investigated in all samples after surgical exeresis of OSCC.

3. Results

During follow-up period, 27/85 (31.7%) OSCC patients developed a second neoplastic event and 15/85 (17.7%) patients died due to malignancy.
32/85 (37.7%) OSCC surgical samples showed presence of PNI in surgical sample. In the population study PNI resulted the only independent clinico-pathological variable significantly related with appearance of a loco-regional recurrence and with disease-specific survival.
Podoplanin overexpression was found in 44/85 (51.7%) in pre-operative incisional biopsies.
Multiple Logistic Regression showed that Podoplanin overexpression in incisional biopsy samples is the only pre-operative variable significantly related to presence of PNI, indeed an altered expression of podoplanin was found in 30/32 PNI positive OSCCs with respect to 14/53 PNI negative OSCCs.

4. Conclusions

The present study confirmed and highlighted the prognostic role of PNI in OSCC patients and for the first time demonstrated that a positive expression of Podoplanin in pre-operative biopsy is significantly related with PNI status. Indeed, podoplanin showed high sensitivity and good performances as negative predictive marker for PNI presence and may be helpful for an accurate preoperative risk stratification of patients with OSCC.

Conflicts of Interest

The authors declare no conflict of interest.

Reference

  1. Foschini, M.P.; Leonardi, E.; Eusebi, L.H.; Farnedi, A.; Poli, T.; Tarsitano, A.; Cocchi, R.; Marchetti, C.; Gentile, L.; Sesenna, E.; et al. Podoplanin and E-cadherin expression in preoperative incisional biopsies of oral squamous cell carcinoma is related to lymph node metastases. Int. J. Surg. Pathol. 2013, 21, 133–141. [Google Scholar] [CrossRef]

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MDPI and ACS Style

Rossi, R.; Tarsitano, A.; Asioli, S.; Piastra, A.; Gabusi, A.; Morandi, L.; Luccarini, L.; Felicetti, L.; Gissi, D.B. Podoplanin Expression and Its Correlation with Perineural Invasion in Oral Squamous Cell Carcinoma. Proceedings 2019, 35, 34. https://doi.org/10.3390/proceedings2019035034

AMA Style

Rossi R, Tarsitano A, Asioli S, Piastra A, Gabusi A, Morandi L, Luccarini L, Felicetti L, Gissi DB. Podoplanin Expression and Its Correlation with Perineural Invasion in Oral Squamous Cell Carcinoma. Proceedings. 2019; 35(1):34. https://doi.org/10.3390/proceedings2019035034

Chicago/Turabian Style

Rossi, Roberto, Achille Tarsitano, Sofia Asioli, Alice Piastra, Andrea Gabusi, Luca Morandi, Laura Luccarini, Laura Felicetti, and Davide B. Gissi. 2019. "Podoplanin Expression and Its Correlation with Perineural Invasion in Oral Squamous Cell Carcinoma" Proceedings 35, no. 1: 34. https://doi.org/10.3390/proceedings2019035034

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