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Proceeding Paper

Synthesis of 1,3-Oxazoles via Van Leusen Reaction in a Pressure Reactor and Preliminary Studies of Cations Recognition †

by
Verónica G. García-Ramírez
1,
Claudia Contreras-Celedón
1,
Gabriela Rodriguez-García
2,
Luis Chacón-García
1 and
Carlos J. Cortes-García
1,*
1
Laboratorio de Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Ciudad Universitaria C.P., 58033 Morelia, Michoacán, Mexico
2
Laboratorio de Productos Naturales, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Ciudad Universitaria C.P., 58033 Morelia, Michoacán, Mexico
*
Author to whom correspondence should be addressed.
†
Presented at the 23rd International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2019; Available online: https://ecsoc-23.sciforum.net/.
Proceedings 2019, 41(1), 7; https://doi.org/10.3390/ecsoc-23-06463
Published: 31 December 2019
(This article belongs to the Proceedings of The 23rd International Electronic Conference on Synthetic Organic Chemistry)
Versions Notes

Abstract

Six 1,3-oxazoles were synthetized in moderate to good yields by Van Leusen reaction in a pressure reactor. The methodology allowed to decrease the reaction times reported in the literature from hours to 20 min. In addition, preliminary qualitative recognition of cations with some synthetized oxazoles such as Hg2+, Ni2+, Zn2+, Ag+, Cu2+, Pb2+ was done and a “turn off” effect was observed with Ni2+. Finally, the 1,3-oxazoles could be of biological relevance because they are considered privileged nucleus in medicinal chemistry and therefore will be useful to obtain pharmacophoric hybrid molecules.
Keywords: 1,3-oxazoles; Van Leusen; cation recognition 1,3-oxazoles; Van Leusen; cation recognition

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MDPI and ACS Style

García-Ramírez, V.G.; Contreras-Celedón, C.; Rodriguez-García, G.; Chacón-García, L.; Cortes-García, C.J. Synthesis of 1,3-Oxazoles via Van Leusen Reaction in a Pressure Reactor and Preliminary Studies of Cations Recognition. Proceedings 2019, 41, 7. https://doi.org/10.3390/ecsoc-23-06463

AMA Style

García-Ramírez VG, Contreras-Celedón C, Rodriguez-García G, Chacón-García L, Cortes-García CJ. Synthesis of 1,3-Oxazoles via Van Leusen Reaction in a Pressure Reactor and Preliminary Studies of Cations Recognition. Proceedings. 2019; 41(1):7. https://doi.org/10.3390/ecsoc-23-06463

Chicago/Turabian Style

García-Ramírez, Verónica G., Claudia Contreras-Celedón, Gabriela Rodriguez-García, Luis Chacón-García, and Carlos J. Cortes-García. 2019. "Synthesis of 1,3-Oxazoles via Van Leusen Reaction in a Pressure Reactor and Preliminary Studies of Cations Recognition" Proceedings 41, no. 1: 7. https://doi.org/10.3390/ecsoc-23-06463

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