Nanocomposites for Enhanced Osseointegration of Dental and Orthopedic Implants Revisited: Surface Functionalization by Carbon Nanomaterial Coatings
Abstract
:1. Introduction
2. Physicomechanical Coating
3. Electrochemical Coating
4. Conclusions and Future Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Clarification | Coating Method | CNM | Conjugation | Coating Quality (Features and Process Rate) | Biological Evaluation | Osteogenic and Antibacterial Activities | Ref. |
---|---|---|---|---|---|---|---|
Physicomechanical Method | Plasma spraying | CNT | HAp | FDA-approved method and commonly used | In vivo (rat and mouse) | Newly grown bone, no periosteal reactions, and restoration of healthy osteoblast and osteocyte | [21] |
Graphene | CS | In vivo (rabbit) | Newly grown bone cover pores in interface | [22] | |||
Ultrasonic atomization spraying | GO | - | Retains original particle structure; thin and uniform layer | In vitro (BM-MSC) and in vivo (rat) | Increased cell adhesion, proliferation, and osteogenic markers; in vivo osseointegration | [23] | |
Dip coating | ND | - | Simple, fast, and cost-effective | In vitro (NHDF and calvariae primary osteoblast) | Enhanced cell growth; inhibition of Staphylococcus aureus colonization | [24] | |
MWCNT | Collagen | In vitro (MSC) | Increased proliferation and ALP activity | [25] | |||
Spin coating | GO | Chitosan | Fast process rate and simple process | In vitro (MC3T3-E1) and in vivo (rat) | Antibacterial effect on Streptococcus mutans; enhanced cell proliferation | [26] | |
rGO | Dex, AA | In vitro (MC3T3-E1) and in vivo (rat) | Enhanced cell viability and adhesion; formation of collagen type I and new bone | [27] | |||
MDD | GO | - | Transparent coating by precise control in nanometer scale | In vitro (MC3T3-E1) and in vivo (rat) | Enhanced proliferation and ALP activity; new bone formation | [28] | |
Electrochemical Method | EPD | GOMA | PBA functionalization GelMA-PBA | High versatility and cost-effectiveness; uniform coating on a porous and complex-shaped substrate with easy accessibility and low cost of equipment | In vitro (osteoblast from rat calvaria) | Enhanced cell viability, proliferation, mineralization, collagen secretion, ALP activity, and osteogenic-relative gene expression; antibacterial effect on Pseudomonas aeruginosa and S. aureus | [29] |
rGO | CS | In vitro (hFOB) | Increased cell viability | [30] | |||
CNF | HAp, PCL | In vitro (MG63) and in vivo (rat) | Antibacterial effect on S. aureus and Escherichia coli; enhanced proliferation and ALP activity | [31] | |||
GO | Chitosan, HAp | In vitro (MG63) | Antibacterial effect on S. aureus; enhanced proliferation and ALP activity | [32] | |||
GO | Chitosan, HAp | In vitro (BM-MSC) and in vivo (rat) | Improved proliferation and differentiation; improved in vivo osseointegration | [33] | |||
ECD | GO | HAp | Low process temperature; coating on geometrically complex surface; controllable coating properties; low cost of equipment | In vitro (MG63) | Enhanced proliferation and ALP activity | [34] | |
SWCNT | HAp | In vitro (human osteoblast) | Enhanced proliferation and ALP activity | [35] | |||
MW-PACVD | ND | HAp | Dense and homogeneous coating; varying crystalline structure; | In vitro (hMSC) | Enhanced proliferation and ALP activity | [36] | |
ND | - | ultrahardness with a very low friction coefficient, chemical inertness, impermeability of the carbon coating, and highly resistant corrosion and erosion processes | In vivo (pig) | Enhanced bone-to-implant contact (BIC) | [37] | ||
Spraying and in situ crosslinking | MWCNT | - | Facile, cheap, and scalable | In vitro (ADSC) | - | [38] | |
Chemical spray pyrolysis | MWCNT | Silver, HAp | Uniform deposition rate at low temperature; pure and reproducible; mass productivity | In vivo (human osteoblast) | Antibacterial property on E. coli, Shigella flexeri, S. aureus, and Bacillus subtilis | [39] | |
Alkali hydrothermal reaction and silane coupling; APTES conjugation | GO | Aspirin | Stable bonding; the feasibility of functionalization | In vitro (MC3T3-E1) | Enhanced proliferation and ALP activity | [40] | |
Chemical assembly | GO | Dopamine | Uniform coating on any shape or structure | In vitro (BM-MSC) and in vivo (rabbit) | Improved cell viability, ALP activity, and mineralization; improved in vivo osseointegration | [41] |
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Kang, M.S.; Lee, J.H.; Hong, S.W.; Lee, J.H.; Han, D.-W. Nanocomposites for Enhanced Osseointegration of Dental and Orthopedic Implants Revisited: Surface Functionalization by Carbon Nanomaterial Coatings. J. Compos. Sci. 2021, 5, 23. https://doi.org/10.3390/jcs5010023
Kang MS, Lee JH, Hong SW, Lee JH, Han D-W. Nanocomposites for Enhanced Osseointegration of Dental and Orthopedic Implants Revisited: Surface Functionalization by Carbon Nanomaterial Coatings. Journal of Composites Science. 2021; 5(1):23. https://doi.org/10.3390/jcs5010023
Chicago/Turabian StyleKang, Moon Sung, Jong Ho Lee, Suck Won Hong, Jong Hun Lee, and Dong-Wook Han. 2021. "Nanocomposites for Enhanced Osseointegration of Dental and Orthopedic Implants Revisited: Surface Functionalization by Carbon Nanomaterial Coatings" Journal of Composites Science 5, no. 1: 23. https://doi.org/10.3390/jcs5010023