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Volume 86
Issue 5
10.5603/ARM.2018.0037
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Advances in Respiratory Medicine is published by MDPI from Volume 90 Issue 4 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Via Medica.
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Article

QuantiFERON-TB-GOLD In-Tube in Patients with Sarcoidosis

by
Wojciech J. Piotrowski
1,*,
Adam J. Białas
1,
Łukasz Gwadera
1,
Anna Kumor-Kisielewska
1,
Marek Fijałkowski
2,
Zofia Kurmanowska
1,
Jerzy Marczak
1,
Witold Górski
1,
Wojciech Angowski
1,
Paweł Górski
1 and
Sylwia Kwiatkowska
3
1
Department of Pneumology and Allergy, Chair of Internal Medicine, Medical University of Lodz, 90-153 Łódź, Poland
2
TB Unit, Regional Hospital for Tuberculosis and Lung Diseases, Tuszyn, Poland
3
Department of Pneumology and Allergy, Chair of Clinical Nursery, Medical University of Lodz, Lodz, Poland
*
Author to whom correspondence should be addressed.
Adv. Respir. Med. 2018, 86(5), 234-239; https://doi.org/10.5603/ARM.2018.0037
Submission received: 24 July 2018 / Revised: 15 October 2018 / Accepted: 15 October 2018 / Published: 30 October 2018

Abstract

Introduction: Sarcoidosis and tuberculosis (TB) are the diseases that share many similarities. Mycobacterium tuberculosis (MTB) culture results are the gold standard for the diagnosis of TB, but false positive results are not rare. The aim was to evaluate the utility of QFT in detecting latent TB infection in a group of sarcoidosis patients with negative history of TB and negative culture/BACTEC results, and checking sarcoidosis activity influence on the QFT results. Additionally, we assessed if QFT negative result may strengthen the suspicion that positive culture/BACTEC results are false positive. Material and methods: 37 culture-negative and 6 culture-positive sarcoidosis patients were enrolled. On the basis of clinical and radiological data TB was considered unlikely (false-positive results). A control group consisted of age-matched subjects with excluded TB (n = 37). QuantiFERON-TB GOLD In-Tube (QIAGEN, USA) was used according to the manual. Test validity was checked basing on the results obtained from a low-risk (n = 21) and active TB group (n = 23). Results: The frequency of positive results tended to be higher in MTB(–) sarcoidosis (24.3% vs. 13.5% for the control group, p = 0.37), but was similar to the general population. None of culture-positive sarcoidosis patients was QFT-positive. The positive results were equally distributed among patients with active and inactive sarcoidosis. Conclusions: QFT has been found to be the useful test for the detection of latent TB infection in sarcoidosis patients. In addition, we confirm that sarcoidosis activity does not negatively influence the result of QFT. Moreover, QFT would be proposed as a cost-saving diagnostic test providing additional diagnostic information when false positive MTB culture result in the sarcoidosis patient is highly suspected. However, in each case clinical, radiological and epidemiological data should be considered before taking the therapeutic decision.
Keywords: IGRA; quantiferon test; sarcoidosis; tuberculosis IGRA; quantiferon test; sarcoidosis; tuberculosis

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MDPI and ACS Style

Piotrowski, W.J.; Białas, A.J.; Gwadera, Ł.; Kumor-Kisielewska, A.; Fijałkowski, M.; Kurmanowska, Z.; Marczak, J.; Górski, W.; Angowski, W.; Górski, P.; et al. QuantiFERON-TB-GOLD In-Tube in Patients with Sarcoidosis. Adv. Respir. Med. 2018, 86, 234-239. https://doi.org/10.5603/ARM.2018.0037

AMA Style

Piotrowski WJ, Białas AJ, Gwadera Ł, Kumor-Kisielewska A, Fijałkowski M, Kurmanowska Z, Marczak J, Górski W, Angowski W, Górski P, et al. QuantiFERON-TB-GOLD In-Tube in Patients with Sarcoidosis. Advances in Respiratory Medicine. 2018; 86(5):234-239. https://doi.org/10.5603/ARM.2018.0037

Chicago/Turabian Style

Piotrowski, Wojciech J., Adam J. Białas, Łukasz Gwadera, Anna Kumor-Kisielewska, Marek Fijałkowski, Zofia Kurmanowska, Jerzy Marczak, Witold Górski, Wojciech Angowski, Paweł Górski, and et al. 2018. "QuantiFERON-TB-GOLD In-Tube in Patients with Sarcoidosis" Advances in Respiratory Medicine 86, no. 5: 234-239. https://doi.org/10.5603/ARM.2018.0037

APA Style

Piotrowski, W. J., Białas, A. J., Gwadera, Ł., Kumor-Kisielewska, A., Fijałkowski, M., Kurmanowska, Z., Marczak, J., Górski, W., Angowski, W., Górski, P., & Kwiatkowska, S. (2018). QuantiFERON-TB-GOLD In-Tube in Patients with Sarcoidosis. Advances in Respiratory Medicine, 86(5), 234-239. https://doi.org/10.5603/ARM.2018.0037

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