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Volume 88
Issue 6
10.5603/ARM.a2020.0188
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Advances in Respiratory Medicine is published by MDPI from Volume 90 Issue 4 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Via Medica.
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Article

Study of Inflammatory Biomarkers in COPD and Asthma Exacerbations

by
Alice G. Vassiliou
1,
Vlassios Vitsas
2,
Matina Kardara
1,
Chrysi Keskinidou
1,
Pinelopi Michalopoulou
2,
Nikoletta Rovina
3,
Ioanna Dimopoulou
1,
Stylianos E. Orfanos
1,4,
Georgios Tsoukalas
2,
Antonia Koutsoukou
3 and
Anastasia Kotanidou
1,*
1
1st Department of Critical Care Medicine & Pulmonary Services, National and Kapodistrian University of Athens, Medical School, Evangelismos Hospital, Athens, Greece
2
4th Pulmonary Department, Sotiria Chest Disease Hospital, Athens, Greece
3
Centre for Respiratory Failure and Intensive Care Unit, Sotiria Chest Disease Hospital, Athens, Greece
4
2nd Department of Critical Care Medicine, National and Kapodistrian University of Athens, Medical School, Attikon Hospital, Athens, Greece
*
Author to whom correspondence should be addressed.
Adv. Respir. Med. 2020, 88(6), 558-566; https://doi.org/10.5603/ARM.a2020.0188
Submission received: 29 May 2020 / Revised: 15 October 2020 / Accepted: 15 October 2020 / Published: 30 December 2020

Abstract

Introduction: Exacerbations are critical events in the course of asthma and chronic obstructive pulmonary disease (COPD). These events are potentially life-threatening, and the studies have shown that they have tremendous implications on long-term disease control and the overall prognosis of the patients. The aim of this study was to examine adipokines, cytokines and C-reactive protein (CRP) as potential biomarkers in asthma and COPD. Material and methods: Prospective cohort study of COPD and asthma patients treated for acute exacerbations. Thirty-nine COPD patients and 15 asthmatic patients were included in the study. Leptin, adiponectin, resistin, interleukin (Il)-6, 8, 18, tumor necrosis factor-α (TNF-α), and CRP were measured at three time points: on admission, at resolution and at the stable phase. Pre- and post-bronchodilation spirometry was additionally performed at resolution and at the stable phase. Results: In COPD patients, leptin, leptin/adiponectin (L/A) ratio and resistin were elevated on admission compared to the stable phase. In asthmatic patients, leptin levels were raised on admission compared to the stable phase, and adiponectin was elevated at resolution compared to admission. In both diseases, CRP was significantly increased on admission compared to both resolution and stable disease. Finally, TNF-α could distinguish between asthma and COPD stable phase. Conclusions: Leptin and CRP levels may be useful biomarkers in monitoring COPD and asthma response to treatment during an exacerbation episode. Hypoadiponectinemia was detected in asthma and COPD during all stages of the diseases. TNF-α could distinguish between asthma and COPD stable phase.
Keywords: COPD; asthma; biomarkers; adipokines; cytokines COPD; asthma; biomarkers; adipokines; cytokines

Share and Cite

MDPI and ACS Style

Vassiliou, A.G.; Vitsas, V.; Kardara, M.; Keskinidou, C.; Michalopoulou, P.; Rovina, N.; Dimopoulou, I.; Orfanos, S.E.; Tsoukalas, G.; Koutsoukou, A.; et al. Study of Inflammatory Biomarkers in COPD and Asthma Exacerbations. Adv. Respir. Med. 2020, 88, 558-566. https://doi.org/10.5603/ARM.a2020.0188

AMA Style

Vassiliou AG, Vitsas V, Kardara M, Keskinidou C, Michalopoulou P, Rovina N, Dimopoulou I, Orfanos SE, Tsoukalas G, Koutsoukou A, et al. Study of Inflammatory Biomarkers in COPD and Asthma Exacerbations. Advances in Respiratory Medicine. 2020; 88(6):558-566. https://doi.org/10.5603/ARM.a2020.0188

Chicago/Turabian Style

Vassiliou, Alice G., Vlassios Vitsas, Matina Kardara, Chrysi Keskinidou, Pinelopi Michalopoulou, Nikoletta Rovina, Ioanna Dimopoulou, Stylianos E. Orfanos, Georgios Tsoukalas, Antonia Koutsoukou, and et al. 2020. "Study of Inflammatory Biomarkers in COPD and Asthma Exacerbations" Advances in Respiratory Medicine 88, no. 6: 558-566. https://doi.org/10.5603/ARM.a2020.0188

APA Style

Vassiliou, A. G., Vitsas, V., Kardara, M., Keskinidou, C., Michalopoulou, P., Rovina, N., Dimopoulou, I., Orfanos, S. E., Tsoukalas, G., Koutsoukou, A., & Kotanidou, A. (2020). Study of Inflammatory Biomarkers in COPD and Asthma Exacerbations. Advances in Respiratory Medicine, 88(6), 558-566. https://doi.org/10.5603/ARM.a2020.0188

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