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Volume 90
Issue 2
10.5603/ARM.a2022.0018
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Advances in Respiratory Medicine is published by MDPI from Volume 90 Issue 4 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Via Medica.
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Review

Therapeutic Use of Intravenous Selenium in Respiratory and Immunological Diseases: A Narrative Review

by
Carlos Rocha Oliveira
1,2,3,
Emille Tejo Viana
4,
Thaina Ferreira Gonçalves
4,
José Roberto Mateus Silva
1,2,3 and
Rodolfo P Vieira
1,5,6,7,*
1
GAP Biotech, Rua Comendador Remo Cesaroni 223, São José dos Campos 12243-020, Brazil
2
Anhembi Morumbi University, School of Medicine, São José dos Campos, Brazil
3
Post-Graduation Program in Biomedical Engineering, Federal University of São Paulo (UNIFESP), São José dos Campos, Brazil
4
Anhembi Morumbi University, São Paulo, Brazil
5
Post-Graduation Program in Sciences of Human Movement and Rehabilitation Federal University of São Paulo (UNIFESP), São José dos Campos, Brazil
6
Post-Graduation Program in Bioengineering, Universidade Brasil, São Paulo, Brazil
7
Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), São José dos Campos, Brazil
*
Author to whom correspondence should be addressed.
Adv. Respir. Med. 2022, 90(2), 134-142; https://doi.org/10.5603/ARM.a2022.0018
Submission received: 14 August 2021 / Revised: 17 January 2022 / Accepted: 17 January 2022 / Published: 31 January 2022

Abstract

The oxidative stress caused by systemic inflammatory response syndrome (SIRS), septic shock, and sepsis, is a risk factor triggering an increase in mortality in patients diagnosed with these pathologies. Selenium (Se) is an essential mineral that has antioxidant and cytoprotective functions, being strongly associated with the proper functioning of intracellular metabolic processes. In this context, the present study aims to investigate de therapeutic effects of intravenous selenium use considering pathologies such as SIRS, septic shock, sepsis, acute respiratory distress syndrome (ARDS), ventilator associated pneumonia (VAP), and coronavirus disease (COVID-19). This is an narrative literature review in which six main articles found in databases of SciELO, PubMed, and Google Scholar, were selected and analyzed. As a result, articles were found evidencing the benefit of Se in the inflammatory response, increasing the GPx-3 activity and decreasing the inflammatory cytokines, in addition to generating a lower risk of VAP, shortening the hospitalization time, and mortality. Thus, Se supplementation has beneficial evidence for acute respiratory diseases and should be considered as a viable option as adjuvant therapy.
Keywords: sodium selenite; selenium; respiratory system; immune response; respiratory disorder sodium selenite; selenium; respiratory system; immune response; respiratory disorder

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MDPI and ACS Style

Oliveira, C.R.; Viana, E.T.; Gonçalves, T.F.; Silva, J.R.M.; Vieira, R.P. Therapeutic Use of Intravenous Selenium in Respiratory and Immunological Diseases: A Narrative Review. Adv. Respir. Med. 2022, 90, 134-142. https://doi.org/10.5603/ARM.a2022.0018

AMA Style

Oliveira CR, Viana ET, Gonçalves TF, Silva JRM, Vieira RP. Therapeutic Use of Intravenous Selenium in Respiratory and Immunological Diseases: A Narrative Review. Advances in Respiratory Medicine. 2022; 90(2):134-142. https://doi.org/10.5603/ARM.a2022.0018

Chicago/Turabian Style

Oliveira, Carlos Rocha, Emille Tejo Viana, Thaina Ferreira Gonçalves, José Roberto Mateus Silva, and Rodolfo P Vieira. 2022. "Therapeutic Use of Intravenous Selenium in Respiratory and Immunological Diseases: A Narrative Review" Advances in Respiratory Medicine 90, no. 2: 134-142. https://doi.org/10.5603/ARM.a2022.0018

APA Style

Oliveira, C. R., Viana, E. T., Gonçalves, T. F., Silva, J. R. M., & Vieira, R. P. (2022). Therapeutic Use of Intravenous Selenium in Respiratory and Immunological Diseases: A Narrative Review. Advances in Respiratory Medicine, 90(2), 134-142. https://doi.org/10.5603/ARM.a2022.0018

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