High-Throughput, Volume 9, Issue 3

2020 September - 3 articles

Cover Story: Recent advances in microbiome studies have revealed much information about how the gut virome, mycobiome, and gut bacteria influence health and disease. Over the years, many studies have reported associations between the gut microflora under different pathological conditions. However, information about the role of gut metabolites and the mechanisms by which the gut microbiota affect health and disease does not provide enough evidence. Recent advances in next-generation sequencing and metabolomics coupled with large, randomized clinical trials are helping scientists to understand whether gut dysbiosis precedes pathology or gut dysbiosis is secondary to pathology. In this review, we discuss our current knowledge on the impact of gut bacteria, virome, and mycobiome interactions with the host and how they could be manipulated to promote health. View this paper.

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Articles (3)

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Feature Paper
Review

20 Citations

10,216 Views

22 Pages

Health Impact and Therapeutic Manipulation of the Gut Microbiome

Eric Banan-Mwine Daliri,
Fred Kwame Ofosu,
Ramachandran Chelliah,
Byong Hoon Lee and
Deog-Hwan Oh

High-Throughput2020, 9(3), 17;https://doi.org/10.3390/ht9030017

29 July 2020

Recent advances in microbiome studies have revealed much information about how the gut virome, mycobiome, and gut bacteria influence health and disease. Over the years, many studies have reported associations between the gut microflora under differen...

Full Article

Article

26 Citations

5,979 Views

17 Pages

Influence of the Ovine Genital Tract Microbiota on the Species Artificial Insemination Outcome. A Pilot Study in Commercial Sheep Farms

Malena Serrano,
Eric Climent,
Fernando Freire,
Juan F. Martínez-Blanch,
Carmen González,
Luis Reyes,
M. Carmen Solaz-Fuster,
Jorge H. Calvo,
M. Ángeles Jiménez and
Francisco M. Codoñer

High-Throughput2020, 9(3), 16;https://doi.org/10.3390/ht9030016

6 July 2020

To date, there is a lack of research into the vaginal and sperm microbiome and its bearing on artificial insemination (AI) success in the ovine species. Using hypervariable regions V3–V4 of the 16S rRNA, we describe, for the first time, the com...

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Article

1 Citations

5,386 Views

17 Pages

Dark Proteome Database: Studies on Disorder

Nelson Perdigão,
Pedro M. C. Pina,
Cátia Rocha,
João Manuel R. S. Tavares and
Agostinho Rosa

High-Throughput2020, 9(3), 15;https://doi.org/10.3390/ht9030015

30 June 2020

There is a misconception that intrinsic disorder in proteins is equivalent to darkness. The present study aims to establish, in the scope of the Swiss-Prot and Dark Proteome databases, the relationship between disorder and darkness. Three distinct pr...

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