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Volume 6
Issue 4
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Eur. Burn J., Volume 6, Issue 4 (December 2025) – 2 articles

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16 pages, 3170 KB  
Article
Assessment of Attenuation Coefficient and Blood Flow at Depth in Pediatric Thermal Hand Injuries Using Optical Coherence Tomography: A Clinical Study
by Beke Sophie Larsen, Tina Straube, Kathrin Kelly, Robert Huber, Madita Göb, Julia Siebert, Lutz Wünsch and Judith Lindert
Eur. Burn J. 2025, 6(4), 54; https://doi.org/10.3390/ebj6040054 - 1 Oct 2025
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Abstract
Background: Optical Coherence Tomography (OCT) is a high-resolution imaging technique capable of quantifying Blood Flow at Depth (BD) and the Attenuation Coefficient (AC). However, the clinical relevance of these parameters in burn assessment remains unclear. This study investigated whether OCT-derived metrics can differentiate [...] Read more.
Background: Optical Coherence Tomography (OCT) is a high-resolution imaging technique capable of quantifying Blood Flow at Depth (BD) and the Attenuation Coefficient (AC). However, the clinical relevance of these parameters in burn assessment remains unclear. This study investigated whether OCT-derived metrics can differentiate between superficial and deep pediatric hand burns. Method: This prospective, single-center study analyzed 73 OCT scans from 37 children with thermal hand injuries. A structured algorithm was used to evaluate AC and BD. Results: The mean AC was 1.61 mm−1 (SD ± 0.48), with significantly higher values in deep burns (2.11 mm−1 ± 0.53) compared to superficial burns (1.49 mm−1 ± 0.38; p < 0.001), reflecting increased optical density in more severe burns. BD did not differ significantly between burn depths, although superficial burns more often showed visible capillary networks. Conclusions: This is the first study to assess both AC and BD using OCT in pediatric hand burns. AC demonstrated potential as a diagnostic marker for burn depth, whereas BD had limited utility. Image quality limitations highlight the need for technical improvements to enhance OCT’s clinical application. Full article
(This article belongs to the Special Issue Innovative Applications and Challenges of Emerging Materials and Technologies in Burn Treatment)
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19 pages, 604 KB  
Review
Managing Infections in Burn Patients: Strategies and Considerations for Antimicrobial Dosing
by Abdullah F. Alharthi, Khalid Al Sulaiman, Sultan Alotaibi, Rahaf Alqahtani, Nader Damfu, Aisha Alharbi, Sufyan Alomair, Haifa A. Alhaidal and Ohoud Aljuhani
Eur. Burn J. 2025, 6(4), 53; https://doi.org/10.3390/ebj6040053 - 1 Oct 2025
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Abstract
Burn injuries are a major cause of morbidity and mortality, largely due to complications such as infection. Impairment of the immune system following burns increases susceptibility to both internal and external infections, underscoring the need for effective infection control strategies in burn care. [...] Read more.
Burn injuries are a major cause of morbidity and mortality, largely due to complications such as infection. Impairment of the immune system following burns increases susceptibility to both internal and external infections, underscoring the need for effective infection control strategies in burn care. In addition, burn patients frequently exhibit profound alterations in drug pharmacokinetics and pharmacodynamics (PK/PD), particularly during the resuscitation and hypermetabolic phases. In the resuscitation phase, increased capillary permeability and reduced cardiac output can prolong drug distribution, delay therapeutic response, lower peak plasma concentrations, and slow elimination. In contrast, the hypermetabolic phase is characterized by elevated catecholamine levels and enhanced tissue perfusion, which accelerate drug distribution and clearance. These physiological changes often necessitate antimicrobial dose adjustments to maintain therapeutic efficacy. This review emphasizes the critical importance of infection prevention and management in burn patients, with a focus on optimizing antimicrobial dosing and therapeutic monitoring in the context of PK/PD alterations. Full article
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